[3-(甲基丙烯酰氨基)丙基]二甲基(3-硫代丙基)氢氧化铵内盐 | 5205-95-8

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物 - 无环羧酸
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 中文名称: [3-(甲基丙烯酰氨基)丙基]二甲基(3-硫代丙基)氢氧化铵内盐
• 中文别名: N,N-二甲基-N-甲基丙烯酰胺基丙基-N,N-二甲基-N-丙烷磺酸内盐；(3-(甲基乙烯酰胺)丙基)二甲基-(3-磺酸)铵
• 英文名称: N,N-dimethyl-N-(3-sulfopropyl)-3'-methacrylamidopropanaminium inner salt
• 英文别名: 3-[N-(3-methacrylamidopropyl)-N,N-dimethyl]ammoniopropane sulfonate；methacrylamide propyl-N,N-dimethylpropane sulfonate；Ralu and Mer SPP；DMAPPS；dimethyl{3-[(2-methyl-1-oxoallyl)amino]propyl}-3-sulfopropylammonium hydroxide；N-(3-sulfopropyl)-N-methacryloylamido-propyl-N,N-dimethylammonium betaine；3-[Dimethyl-[3-(2-methylprop-2-enoylamino)propyl]azaniumyl]propane-1-sulfonate
• CAS: 5205-95-8
• 化学式: C₁₂H₂₄N₂O₄S
• mdl: MFCD00080642
• 分子量: 292.4
• InChiKey: OIETYYKGJGVJFT-UHFFFAOYSA-N

物化性质

• 熔点：
  190 °C (dec.)(lit.)
• 稳定性/保质期：

  避免强氧化剂的影响。

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  94.7
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 危险品标志：
  C
• 危险类别码：
  R20/21/22
• 海关编码：
  2924199090
• 安全说明：
  S26

反应信息

• 作为反应物：
  描述：

  [3-(甲基丙烯酰氨基)丙基]二甲基(3-硫代丙基)氢氧化铵内盐 、 巯基乙胺 在 2,2'-azobis(2-methylpropionamidine) dihydrochloride 作用下， 以 水 为溶剂， 生成 3-[3-[[3-(2-Aminoethylsulfanyl)-2-methylpropanoyl]amino]propyl-dimethylazaniumyl]propane-1-sulfonate
  参考文献：
  名称：

  Small and Stable Sulfobetaine Zwitterionic Quantum Dots for Functional Live-Cell Imaging

  摘要：

  We have developed a novel surface coating for semiconductor quantum dots (QDs) based on a heterobifunctional ligand that overcomes most of the previous limits of these fluorescent probes in bioimaging applications. Here we show that QDs capped with bidentate zwitterionic dihydrolipoic acid-sulfobetaine (DHLA-SB) ligands are a favorable alternative to polyethylene glycol-coated nanoparticles since they combine small sizes, low nonspecific adsorption, preserved optical properties, and excellent stability over time and a wide range of pH and salinity. Additionally, these QDs can easily be functionalized with biomolecules such as streptavidin (SA) and biotin. We applied streptavidin-functionalized DHLA-SB QDs to track the intracellular recycling of cannabinoid receptor 1 (CB1R) in live cells. These QDs selectively recognized the pool of receptors at the cell surface via SA-biotin interactions with negligible nonspecific adsorption. The QDs retained their optical properties, allowing the internalization of CB1R into endosomes to be followed. Moreover, the cellular activity was apparently unaffected by the probe.

  DOI：

  10.1021/ja1005493
• 作为产物：
  描述：

  1,3-丙烷磺内酯 、 N-(3-二甲氨基丙基)甲基丙烯酰胺 以 乙醚 为溶剂， 反应 24.0h， 以86%的产率得到[3-(甲基丙烯酰氨基)丙基]二甲基(3-硫代丙基)氢氧化铵内盐
  参考文献：
  名称：

  磺基甜菜碱聚合物水溶液中水的氢键网络结构

  摘要：

  将聚 (N,N-二甲基氨基丙基甲基丙烯酰胺) (聚 (DMAPMA)) 与 1,3-丙磺酸内酯和 1,4-丁磺酸内酯一起温育，得到具有不同含量 N,N-二甲基-N-(3-磺丙基)-的聚合物分别为3'-甲基丙烯酰胺基丙胺内盐残基和N,N-二甲基-N-(4-磺丁基)-3'-甲基丙烯酰胺基丙胺内盐残基。使用偏振拉曼光谱中的 O-H 拉伸轮廓分析了磺基甜菜碱聚合物水溶液中水的结构和氢键。随着磺基甜菜碱残基含量的增加，聚合物水溶液中 O-H 拉伸长程耦合对应的集体带的相对强度（C 值）变大，接近纯水的 C 值.

  DOI：

  10.1021/jp020185r

文献信息

• Synthesis and structures of zwitterionic polymers to induce electrostatic interaction with PDMS surface treated by air-plasma
  作者：Mutsuo Tanaka、Yoshiki Hirata、Takahiro Sawaguchi、Shigeru Kurosawa

  DOI：10.24820/ark.5550190.p010.321

  日期：——

  Various zwitterionic polymers, sulfobetaine and phosphoryl choline derivatives were synthesized in order to investigate zwitterionic polymer structures toward surface modification of PDMS, where the adsorption of zwitterionic polymers on polydimethylsiloxane surface treated with air-plasma was induced by the electrostatic interaction,. The electrostatic interaction was evaluated with hydrophilicity

  合成了各种两性离子聚合物、磺基甜菜碱和磷酰胆碱衍生物，以研究两性离子聚合物结构对 PDMS 的表面改性，其中两性离子聚合物在用空气-等离子体处理的聚二甲基硅氧烷表面上的吸附是由静电相互作用引起的。用亲水性评价静电相互作用。结果表明，具有较高分子量、较低分子量分布和较短烷基链的磺基甜菜碱聚合物提供了高静电相互作用。带有苯基叠氮基团的磺基甜菜碱聚合物与PDMS表面表现出类似的静电相互作用，是一种很有前途的聚二甲基硅氧烷表面改性材料。
• [EN] POLYMERIZABLE FUSED TRICYCLIC COMPOUNDS AS ABSORBERS OF UV AND VISIBLE LIGHT<br/>[FR] COMPOSÉS TRICYCLIQUES FUSIONNÉS POLYMÉRISABLES EN TANT QU'ABSORBEURS DE LUMIÈRE UV ET VISIBLE
  申请人：JOHNSON & JOHNSON VISION CARE

  公开号：WO2020261021A1

  公开（公告）日：2020-12-30

  Described are polymerizable fused tricyclic compounds of formula I: wherein R1, R2, R3, m, n, t, and rings B, C, and D are as defined herein. The compounds absorb various wavelengths of ultraviolet and/or visible light (such as high energy visible light) and are suitable for incorporation in a variety of products, such as biomedical devices and ophthalmic devices.

  描述了公式I的可聚合的融合三环化合物，其中R1、R2、R3、m、n、t和环B、C和D的定义如本文所述。这些化合物吸收各种紫外线和/或可见光波长（如高能可见光），适用于各种产品中，如生物医学器械和眼科器械。
• HYDRATED CRYSTALLINE FORM OF 2-ACRYLAMIDO-2-METHYLPROPANE SULFONIC ACID
  申请人：S.P.C.M. SA

  公开号：US20200031765A1

  公开（公告）日：2020-01-30

  The present invention relates to a hydrated crystalline form of 2-acrylamido-2-methylpropane sulfonic acid having a 2-theta powder X-ray diffraction diagram comprising peaks at 10.58°, 11.2°, 12.65°, 13.66°, 16.28°, 18.45°, 20°, 20.4°, 22.5°, 25.5°, 25.88°, 26.47°, 28.52°, 30.28°, 30.8°, 34.09°, 38.19°, 40.69°, 41.82°, 43.74°, 46.04° degrees (+/−0.1°). The present invention also relates to a production method for this form of 2-acrylamido-2-methylpropane sulfonic acid and a preparation method for an aqueous solution A of a salt of this form of 2-acrylamido-2-methylpropane sulfonic acid, and the (co)polymer of this form of -acrylamido-2-methylpropane sulfonic acid.

  本发明涉及一种2-丙烯酰胺-2-甲基丙磺酸的水合晶体形式，其2-theta粉末X射线衍射图包含在10.58°、11.2°、12.65°、13.66°、16.28°、18.45°、20°、20.4°、22.5°、25.5°、25.88°、26.47°、28.52°、30.28°、30.8°、34.09°、38.19°、40.69°、41.82°、43.74°、46.04°度（±0.1°）处的峰。本发明还涉及这种形式的2-丙烯酰胺-2-甲基丙磺酸的生产方法，以及这种形式的2-丙烯酰胺-2-甲基丙磺酸盐的水溶液A的制备方法，以及这种形式的-丙烯酰胺-2-甲基丙磺酸的（共）聚合物。
• POLYMER COMPOSITIONS CONTAINING GRAFTED POLYMERIC NETWORKS AND PROCESSES FOR THEIR PREPARATION AND USE
  申请人：Johnson & Johnson Vision Care, Inc.

  公开号：US20180037690A1

  公开（公告）日：2018-02-08

  Provided are polymer compositions made by a process comprising: (a) providing a first reactive composition containing: (i) a polymerization initiator that is capable, upon a first activation, of forming two or more free radical groups, at least one of which is further activatable by subsequent activation; (ii) one or more ethylenically unsaturated compounds; and (iii) a crosslinker; (b) subjecting the first reactive composition to a first activation step such that the first reactive composition polymerizes therein to form a crosslinked substrate network containing a covalently bound activatable free radical initiator, (c) combining the crosslinked substrate network with a second reactive composition containing one or more ethylenically unsaturated compounds; and (d) activating the covalently bound activatable free radical initiator of the crosslinked substrate network such that the second reactive composition polymerizes therein with the crosslinked substrate network to form a grafted polymeric network and a byproduct polymer. Also provided are precursors to the polymer compositions, processes for preparation of the polymer compositions, and methods of using the polymer compositions, for instance in medical devices.

  提供的是由包括以下步骤的过程制备的聚合物组合物：(a)提供含有：(i)能够在第一激活时形成两个或更多自由基团的聚合引发剂，其中至少一个可以通过后续激活进一步激活；(ii)一个或多个乙烯基不饱和化合物；和(iii)交联剂的第一反应组合物；(b)将第一反应组合物暴露于第一激活步骤，使第一反应组合物在其中聚合形成含有共价结合的可激活自由基引发剂的交联基底网络；(c)将交联基底网络与含有一个或多个乙烯基不饱和化合物的第二反应组合物结合；和(d)激活交联基底网络的共价结合的可激活自由基引发剂，使第二反应组合物在其中与交联基底网络聚合形成嵌接聚合物网络和副产物聚合物。还提供了聚合物组合物的前体、制备聚合物组合物的过程以及使用聚合物组合物的方法，例如在医疗器械中的应用。
• HYDROXYPHENYL PHENANTHROLINES AS POLYMERIZABLE BLOCKERS OF HIGH ENERGY LIGHT
  申请人：Johnson & Johnson Vision Care, Inc.

  公开号：US20190002459A1

  公开（公告）日：2019-01-03

  Described are high energy light blocking compounds and ophthalmic devices containing the compounds. In particular, described are hydroxyphenyl phenanthroline structures with polymerizable functionality that block high energy light and are visibly transparent. The hydroxyphenyl phenanthroline structures can be incorporated into ophthalmic devices, such as hydrogel contact lenses, to protect eyes from high energy light radiation.

  描述了高能量光阻挡化合物和含有这些化合物的眼科器械。具体来说，描述了含有可聚合功能的羟基苯基菲啰啉结构，这些结构可以阻挡高能量光并且具有可见透明性。这些羟基苯基菲啰啉结构可以被应用到眼科器械中，比如水凝胶隐形眼镜，以保护眼睛免受高能量光辐射的伤害。