脒基牛磺酸 - CAS号 543-18-0

物化性质

熔点：

263-265°C
密度：

1.73±0.1 g/cm3(Predicted)
溶解度：

DMSO（微溶，加热），甲醇（微溶，加热），水（加热）
物理描述：

Solid
稳定性/保质期：

按规格使用和贮存，不会发生分解，避免与氧化物接触。

计算性质

辛醇/水分配系数(LogP)：

-2.4
重原子数：

10
可旋转键数：

3
环数：

0.0
sp3杂化的碳原子比例：

0.666
拓扑面积：

127
氢给体数：

3
氢受体数：

4

安全信息

危险类别码：

R34
危险品运输编号：

UN 3261
海关编码：

2925290090
安全说明：

S26,S36,S37,S39
储存条件：

储存于阴凉、干燥、通风良好的库房中。远离火种和热源，防止阳光直射，并确保包装密封。应将储存物品与酸类及食用化学品分开存放，切忌混储。储区内应备有合适的材料以处理泄漏物。

SDS

SDS：1d9a5c26bf629db3ace9aa0eb5149f6a

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Name:	2-{[Amino(imino)methyl]amino}ethane-1-sulfonic acid 97% Material Safety Data Sheet
Synonym:	N-Amidinotaurin
CAS:	543-18-0

Section 1 - Chemical Product MSDS Name:2-{[Amino(imino)methyl]amino}ethane-1-sulfonic acid 97% Material Safety Data Sheet
Synonym:N-Amidinotaurin

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
543-18-0	2-{[Amino(imino)methyl]amino}ethane-1-	97%	unlisted

Hazard Symbols: C
Risk Phrases: 34

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Causes burns.
Potential Health Effects
Eye:
Causes eye burns.
Skin:
Causes skin burns.
Ingestion:
Causes gastrointestinal tract burns.
Inhalation:
Causes chemical burns to the respiratory tract.
Chronic:
Not available.

Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Do not induce vomiting. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use foam, dry chemical, or carbon dioxide.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Vacuum or sweep up material and place into a suitable disposal container.

Section 7 - HANDLING and STORAGE
Handling:
Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.
Storage:
Store in a cool, dry place. Store in a tightly closed container.
Corrosives area.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 543-18-0: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: white
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 263 - 265 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C3H9N3O3S
Molecular Weight: 167

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 543-18-0 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
2-{[Amino(imino)methyl]amino}ethane-1-sulfonic acid - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: CORROSIVE SOLID, N.O.S.*
Hazard Class: 8
UN Number: 1759
Packing Group: III
IMO
Shipping Name: CORROSIVE SOLID, N.O.S.
Hazard Class: 8
UN Number: 1759
Packing Group: III
RID/ADR
Shipping Name: CORROSIVE SOLID, N.O.S.
Hazard Class: 8
UN Number: 1759
Packing group: III

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: C
Risk Phrases:
R 34 Causes burns.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 543-18-0: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 543-18-0 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 543-18-0 is not listed on the TSCA inventory.
It is for research and development use only.

SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

合成制备方法

暂无

用途

暂无

上下游信息

上游原料

中文名称英文名称 CAS号化学式分子量

牛磺酸 Tau 107-35-7 C₂H₇NO₃S 125.148
下游产品

中文名称英文名称 CAS号化学式分子量

牛磺酸 Tau 107-35-7 C₂H₇NO₃S 125.148

中文名称	英文名称	CAS号	化学式	分子量
牛磺酸	Tau	107-35-7	C₂H₇NO₃S	125.148

中文名称	英文名称	CAS号	化学式	分子量
牛磺酸	Tau	107-35-7	C₂H₇NO₃S	125.148

反应信息

作为反应物：

描述：

脒基牛磺酸在 sodium hydroxide 、三氯氧磷作用下，生成 N-磷酰脒基牛磺酸

参考文献：

名称：

Morrison et al., Biochemical Journal, 1958, vol. 68, p. 447,448,449

摘要：

DOI：
作为产物：

描述：

S-(2-aminoethyl)isothiouronium bromide hydrobromide 生成脒基牛磺酸

参考文献：

名称：

有机硫化物及相关物质。九。对称的氨基硫代硫酸钠作为抗辐射药物。

摘要：

DOI：

10.1021/jm00331a009

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文献信息

Probiotics. Antistaphylococcal and antifibrinolytic activities of .omega.-amino- and .omega.-guanidinoalkanesulfonic acids

作者：Akira Fujii、Elton S. Cook

DOI：10.1021/jm00239a013

日期：1975.5

the omega-guanidinoalkanesulfonic acids. Most of the omega-aminoalkanesulfonic acids have antifibrinolytic activity, while none of the omega-guanidinoalkanesulfonic acids has significant antifibrinolytic activity. Compound 4 possessed the highest antifibrinolytic activity which was equal to or greater than that of epsilon-aminohexanoic acid.

已经测试了一系列的ω-氨基链烷磺酸（1-5）和ω-胍基链烷磺酸（6-9）的抗葡萄球菌和抗纤溶活性。与γ-氨基丁酰基-L-组氨酸相比，大多数ω-氨基链烷磺酸和6对小鼠的金黄色葡萄球菌感染产生更好的保护作用。在ω-氨基链烷磺酸中，化合物4是最好的抗葡萄球菌药物，而在ω-胍基链烷磺酸中，化合物6是最好的抗葡萄球菌药物。多数ω-氨基链烷磺酸具有抗纤溶活性，而ω-胍基链烷磺酸均不具有显着的抗纤溶活性。化合物4具有最高的抗纤溶活性，其等于或大于ε-氨基己酸的抗纤溶活性。
VISCOSITY-REDUCING EXCIPIENT COMPOUNDS FOR PROTEIN FORMULATIONS

申请人：ReForm Biologics, LLC

公开号：US20160074515A1

公开（公告）日：2016-03-17

The invention encompasses formulations and methods for the production thereof that permit the delivery of concentrated protein solutions. The inventive methods can yield a lower viscosity liquid formulation or a higher concentration of therapeutic or nontherapeutic proteins in the liquid formulation, as compared to traditional protein solutions.

本发明涵盖了制备浓缩蛋白溶液的配方和方法，这些方法可以生产出比传统蛋白溶液更低粘度的液体配方或更高浓度的治疗或非治疗蛋白质液体配方。
Viscosity-Reducing Excipient Compounds for Protein Formulations

申请人：ReForm Biologics, LLC

公开号：US20160096879A1

公开（公告）日：2016-04-07

The invention encompasses formulations and methods for the production thereof that permit the delivery of concentrated protein solutions. The inventive methods can yield a lower viscosity liquid formulation or a higher concentration of therapeutic or nontherapeutic proteins in the liquid formulation, as compared to traditional protein solutions.

本发明涵盖了制备浓缩蛋白质溶液的配方和制备方法。本发明的方法可以制备出比传统蛋白质溶液具有更低粘度的液体配方，或者在液体配方中制备出更高浓度的治疗性或非治疗性蛋白质。
Kai, Masaaki; Miura, Tetsuro; Kohashi, Kazuya, Chemical and pharmaceutical bulletin, 1981, vol. 29, # 4, p. 1115 - 1120

作者：Kai, Masaaki、Miura, Tetsuro、Kohashi, Kazuya、Ohkura, Yosuke

DOI：——

日期：——
Identification of amino acid residues responsible for taurocyamine binding in mitochondrial taurocyamine kinase from Arenicola brasiliensis

作者：Kumiko Tanaka、Tamotsu Matsumoto、Tomohiko Suzuki

DOI：10.1016/j.bbapap.2011.06.003

日期：2011.10

In order to investigate the residues associated with binding of the substrate taurocyamine in Arenicola mitochondrial taurocyamine kinase (TK), we performed Ala-scanning of the amino acid sequence HTKTV at positions 67-71 on the GS loop, and determined apparent K(m) and V(max) (appK(m) and appV(max), respectively) of the mutant forms for the substrates taurocyamine and glycocyamine. The appK(m) values for taurocyamine of the K69A, T70A and V71A mutants were significantly increased as compared with wild-type, suggesting that these residues are associated with taurocyamine binding. Of special interest is a property of V71A mutant: its catalytic efficiency for glycocyamine was twice that for taurocyamine, indicating that the V71A mutant acts like a glycocyamine kinase, rather than a TK. The role of the amino acid residue K95 of Arenicola MiTK was also examined. K95 was replaced with R, H. V. I. A and E. K95R, K95H and K95I have a 3-fold higher affinity for taurocyamine, and activity was largely lost in K95E. On the other hand, the K95Y mutant showed a rather unique feature: namely, an increase in substrate concentration caused a decrease in initial velocity of the reaction (substrate inhibition). This is the first report on the key amino acid residues responsible for taurocyamine binding in mitochondrial TK. (C) 2011 Elsevier B.V. All rights reserved.

脒基牛磺酸 | 543-18-0

分子结构分类