There is provided a novel compound that inhibits phosphatidylinositol 3-kinase (PI3K) and/or the mammalian target of rapamycin (mTOR) and exhibits anti-tumor activity. The present invention provides a compound represented by the following formula (1) having various substituents that inhibits PI3K and/or mTOR and exhibits anti-tumor activity:
wherein R
1
, R
2
, R
3
, R
4
, R
a
, R
b
, R
c
, and X each have the same meaning as defined in the specification.
提供了一种新型化合物,它抑制
磷脂酰肌醇3-激酶(
PI3K)和/或哺乳动物
雷帕霉素靶蛋白(mTOR),并表现出抗肿瘤活性。本发明提供了一种由以下式(1)表示的化合物,具有各种取代基,可抑制
PI3K和/或mTOR,并表现出抗肿瘤活性:
其中R1、R2、R3、R4、Ra、Rb、Rc和X的含义与规范中定义的含义相同。