A method for producing an alkyl (3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxy-6-heptenoate of the formula (1) (wherein R is a C
1-4
alkyl group), which is an intermediate for a cholesterol-reducing agent (a HMG-CoA reductase inhibitor), etc. A solution containing a compound of the formula (1) is subjected to liquid chromatography treatment using silica gel as the packing material, to separate its epimers contained therein.
一种生产式(1)的(3R,5S)-7-[2-环丙基-4-(4-
氟苯基)
喹啉-3-基]-3,5-二羟基-
6-庚烯酸烷基酯的方法(其中 R 为 C
1-4
烷基),它是
胆固醇还原剂(
HMG-CoA 还原酶
抑制剂)等的中间体。使用
硅胶作为填料,对含有式(1)化合物的溶液进行
液相色谱处理,以分离其中的表聚物。