4-羟基-6-甲氧基-2-(三氟甲基)喹啉 | 1701-21-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 4-羟基-6-甲氧基-2-(三氟甲基)喹啉
• 英文名称: 6-methoxy-2-(trifluoromethyl)quinolin-4-ol
• 英文别名: 4-Hydroxy-6-methoxy-2-trifluormethyl-chinolin；2-trifluoromethyl-4-hydroxy-6-methoxyquinoline；6-methoxy-2-(trifluoromethyl)-1H-quinolin-4-one
• CAS: 1701-21-9
• 化学式: C₁₁H₈F₃NO₂
• mdl: MFCD11855897
• 分子量: 243.185
• InChiKey: LLZDJBZPTTUUPM-UHFFFAOYSA-N

物化性质

• 熔点：
  275-277 °C
• 沸点：
  339.9±37.0 °C(Predicted)
• 密度：
  1.407±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.181
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  6

安全信息

• 海关编码：
  2933499090

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 4-Hydroxy-6-methoxy-2-(trifluoromethyl)quinoline
Synonyms: 6-Methoxy-2-(trifluoromethyl)quinolin-4-ol

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 4-Hydroxy-6-methoxy-2-(trifluoromethyl)quinoline
CAS number: 1701-21-9

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C11H8F3NO2
Molecular weight: 243.2

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen fluoride.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  4-羟基-6-甲氧基-2-(三氟甲基)喹啉 在 硝酸 、 三氯氧磷 作用下， 以 溶剂黄146 、 N,N-二甲基甲酰胺 为溶剂， 反应 13.0h， 生成
  参考文献：
  名称：

  2-三氟甲基-4-氨基-喹啉衍生物及其用途

  摘要：

  本发明公开了一种2‑三氟甲基‑4‑氨基‑喹啉衍生物及其用途，包括具有如下通式I所示的化合物，本发明制得的化合物用于制备抗肿瘤的活性药物，具有良好的抗肿瘤效果，而且稳定性与脂溶性大大提高，代谢能力不受影响，且药物用量少，副作用小、安全性高。

  公开号：

  CN113620874A
• 作为产物：
  描述：

  甲氧苯胺 、 三氟乙酰乙酸乙酯 在 magnesium sulfate 、 溶剂黄146 、 dowtherm A 作用下， 以 乙醇 为溶剂， 反应 16.5h， 生成 4-羟基-6-甲氧基-2-(三氟甲基)喹啉
  参考文献：
  名称：

  天然奎宁生物碱启发的新型喹啉衍生物的设计，合成和抗真菌评价

  摘要：

  受奎宁及其类似物的启发，我们设计，合成和评估了两个系列的喹啉小分子化合物（a和2a）和六个系列的喹啉衍生物（3a - f）的抗真菌活性。结果表明，化合物3e和3f系列表现出显着的杀真菌活性。值得注意的是，化合物3f-4（EC 50 = 0.41μg/ mL）和3f-28（EC 50 = 0.55μg/ mL）显示出优异的体外杀真菌活性和对菌核菌的有效体内治疗作用。初步机理研究表明，化合物3f-4和3f-28可能引起细胞膜通透性改变，活性氧的积累，线粒体膜电位的丧失以及有效抑制菌核菌的发芽和形成。这些结果表明，化合物3f-4和3f-28是对抗源自天然产物的核盘菌的新型潜在杀真菌剂。

  DOI：

  10.1021/acs.jafc.9b04224

文献信息

• [EN] HCV NS3 PROTEASE INHIBITORS<br/>[FR] INHIBITEURS DE LA PROTÉASE NS3 DU VHC
  申请人：MERCK SHARP & DOHME

  公开号：WO2014025736A1

  公开（公告）日：2014-02-13

  The present invention relates to hepatitis C virus (HCV) NS3 protease inhibitors containing a spirocyclic moeity, uses of such compounds, and synthesis of such compounds.

  这项发明涉及含有螺环结构基团的丙型肝炎病毒（HCV）NS3蛋白酶抑制剂，以及这类化合物的用途和合成。
• New quinoline-triazole conjugates: Synthesis, and antiviral properties against SARS-CoV-2
  作者：Israa A. Seliem、Siva S. Panda、Adel S. Girgis、Yassmin Moatasim、Ahmed Kandeil、Ahmed Mostafa、Mohamed A. Ali、Eman S. Nossier、Fatma Rasslan、Aladdin M. Srour、Rajeev Sakhuja、Tarek S. Ibrahim、Zakaria K.M. Abdel-samii、Amany M.M. Al-Mahmoudy

  DOI：10.1016/j.bioorg.2021.105117

  日期：2021.9

  limited. We designed and synthesized three sets of small molecules using quinoline scaffolds. A series of quinoline conjugates (10a-l, 11a-c, and 12a-e) by incorporating 1,2,3-triazole were synthesized via a modified microwave-assisted click chemistry technique. Among the synthesized conjugates, 4-((1-(2-chlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-6-fluoro-2-(trifluoromethyl)quinoline (10g) and 6-fluor

  目前，严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 的治疗选择非常有限。我们使用喹啉支架设计并合成了三组小分子。通过改进的微波辅助点击化学技术合成了一系列通过掺入 1,2,3-三唑的喹啉偶联物（10a-l、11a-c 和 12a-e） 。在合成的缀合物中，4-((1-(2-氯苯基)-1 H -1,2,3-三唑-4-基)甲氧基)-6-氟-2-(三氟甲基)喹啉 (10g) 和 6 -fluoro-4-(2-(1-(4-methoxyphenyl)-1 H -1,2,3-triazol-4-yl)ethoxy)-2-(trifluoromethyl)quinoline (12c) 对 SARS 表现出高效能-冠状病毒-2。化合物 10g 和 12c 的选择性指数 (SI) 也表明与参考药物相比具有显着的功效。
• Proline derivatives and use thereof as drugs
  申请人：Kitajima Hiroshi

  公开号：US20050245538A1

  公开（公告）日：2005-11-03

  The present invention aims at providing compounds having therapeutic effects due to a DPP-IV inhibitory action, and satisfactory as pharmaceutical products. The present inventors have found that derivatives having a substituent introduced into the γ-position of proline represented by the formula (I) wherein each symbol is as defined in the specification, have a potent DPP-IV inhibitory activity, and completed the present invention by increasing the stability.

  本发明旨在提供具有治疗效果的化合物，其作用是通过DPP-IV的抑制作用，并且作为药物产品具有令人满意的效果。本发明人发现，在丙氨酸的γ位上引入取代基的衍生物具有强效的DPP-IV抑制活性，并通过增加稳定性完成了本发明。
• Thiazolidine derivative and medicinal use thereof
  申请人：——

  公开号：US20040259883A1

  公开（公告）日：2004-12-23

  A thiazolidine derivative represented by the formula (I) 1 wherein each symbol is as defined in the specification, and a pharmaceutically acceptable salt thereof exhibit a potent DPP-IV inhibitory activity, and can be provided as an agent for the prophylaxis or treatment of diabetes, an agent for the prophylaxis or treatment of obesity and the like.

  一种噻唑啉衍生物，其化学式为(I)1，其中每个符号如规范中所定义，其药物可接受的盐具有强效的DPP-IV抑制活性，可作为糖尿病的预防或治疗剂，肥胖症的预防或治疗剂等。
• Proline derivatives and the use thereof as drugs
  申请人：——

  公开号：US20040106655A1

  公开（公告）日：2004-06-03

  The present invention aims at providing compounds having therapeutic effects due to a DPP-IV inhibitory action, and satisfactory as pharmaceutical products. The present inventors have found that derivatives having a substituent introduced into the &ggr;-position of proline represented by the formula (I) 1 wherein each symbol is as defined in the specification, have a potent DPP-IV inhibitory activity, and completed the present invention by increasing the stability.

  本发明旨在提供具有治疗作用的化合物，由于DPP-IV抑制作用而具有满意的药物产品。本发明人发现，具有引入取代基的脯氨酸γ-位置的衍生物，其化学式为(I)1，其中每个符号如规范中所定义，具有强效的DPP-IV抑制活性，并通过增加稳定性完成了本发明。