methyl (2E,9R)-9,13-dimethyl-6-oxotetradeca-2,12-dienoate | 793669-89-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: methyl (2E,9R)-9,13-dimethyl-6-oxotetradeca-2,12-dienoate
• CAS: 793669-89-3
• 化学式: C₁₇H₂₈O₃
• 分子量: 280.408
• InChiKey: BRZGHOQUEXARNA-KDHUCADRSA-N

物化性质

• 沸点：
  393.9±35.0 °C(Predicted)
• 密度：
  0.943±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.23
• 重原子数：
  20.0
• 可旋转键数：
  10.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  43.37
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  甲醇 、 methyl (2E,9R)-9,13-dimethyl-6-oxotetradeca-2,12-dienoate 在 双氧水 、 尿素 、 scandium tris(trifluoromethanesulfonate) 、 2,2,2-三氟乙醇 、 二乙胺 作用下， 反应 56.0h， 生成 methyl 2-[3-(3R)-(3,7-dimethyloct-6-enyl)-3-methoxy-1,2-dioxan-6-yl]acetate 、 methyl 2-[3-(3R)-(3,7-dimethyloct-6-enyl)-3-methoxy-1,2-dioxan-6-yl]acetate
  参考文献：
  名称：

  Structure–activity relationship of anti-malarial spongean peroxides having a 3-methoxy-1,2-dioxane structure

  摘要：

  In order to study the structure-activity relationship of anti-malarial spongean peroxides, several analogues concerning with the 6-methoxyacetyl moiety and the 3-pentyl residue in methyl 2-(3-methoxy-3-pentyl-1,2-dioxan-6-yl) acetate were synthesized and evaluated for anti-malarial activity. The tert-butyl ester analogue 14 showed stability in mouse serum and a high selectivity index against the malaria parasite, Plasmodium falciparum, and the citronellyl analogue 31 exhibited the strongest in vitro antimalarial activity among them, and the imidazole analogue 25 showed desirable in vivo anti-malarial activity against P. berghei infected mice. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.04.051
• 作为产物：
  描述：

  在 草酰氯 、 二甲基亚砜 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 methyl (2E,9R)-9,13-dimethyl-6-oxotetradeca-2,12-dienoate
  参考文献：
  名称：

  Structure–activity relationship of anti-malarial spongean peroxides having a 3-methoxy-1,2-dioxane structure

  摘要：

  In order to study the structure-activity relationship of anti-malarial spongean peroxides, several analogues concerning with the 6-methoxyacetyl moiety and the 3-pentyl residue in methyl 2-(3-methoxy-3-pentyl-1,2-dioxan-6-yl) acetate were synthesized and evaluated for anti-malarial activity. The tert-butyl ester analogue 14 showed stability in mouse serum and a high selectivity index against the malaria parasite, Plasmodium falciparum, and the citronellyl analogue 31 exhibited the strongest in vitro antimalarial activity among them, and the imidazole analogue 25 showed desirable in vivo anti-malarial activity against P. berghei infected mice. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.04.051