bivittoside A | 77394-03-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: bivittoside A
• 英文别名: (1S,2S,5S,6S,9S,10S,13S,16S,18R)-16-[(2S,3R,4S,5R)-4,5-dihydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-10-hydroxy-2,6,13,17,17-pentamethyl-6-(4-methylpentyl)-7-oxapentacyclo[10.8.0.02,9.05,9.013,18]icos-11-en-8-one
• CAS: 77394-03-7
• 化学式: C₄₁H₆₆O₁₂
• 分子量: 750.968
• InChiKey: GOYXWSSENLVERY-YZRCTGSKSA-N

物化性质

• 沸点：
  859.6±65.0 °C(Predicted)
• 密度：
  1.29±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  53
• 可旋转键数：
  8
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  185
• 氢给体数：
  6
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  bivittoside A 在 盐酸 、 乙酰氯 作用下， 以 甲醇 、 水 为溶剂， 反应 1.5h， 生成 seychellogenin
  参考文献：
  名称：

  Kitagawa, Isao; Kobayashi, Motomasa; Hori, Manabu, Chemical and pharmaceutical bulletin, 1989, vol. 37, # 1, p. 61 - 67

  摘要：

  DOI：
• 作为产物：
  描述：

  bivittoside B 在 sodium acetate 作用下， 以 溶剂黄146 为溶剂， 反应 120.0h， 生成 bivittoside A
  参考文献：
  名称：

  Kitagawa, Isao; Kobayashi, Motomasa; Hori, Manabu, Chemical and pharmaceutical bulletin, 1989, vol. 37, # 1, p. 61 - 67

  摘要：

  DOI：

文献信息

• Isolation of bivittoside D from sea cucumber and activity thereof
  申请人：Vijay Lakshmi

  公开号：US20050208147A1

  公开（公告）日：2005-09-22

  The present invention provides a process for the isolation of Bivittoside-D, a triterpenoid saponin from the sea cucumber Bohadschia vitiensis and its potent spermicidal and fungicidal activity.
• Compositions of Matter and Methoods to Treat Cancer
  申请人：Adrian Thomas E

  公开号：US20200054657A1

  公开（公告）日：2020-02-20

  The named inventors claim discovery of synergistic anti-cancer effects of combinations of one or more sea cucumber glycosides such as Frondoside A or other sea cucumber glycosides and Andrographolide or an Andrographolide analog, wherein the biological effects are may be more beneficial than the single components making up the said invention. The inventors claim new methods and compositions of matter to treat cancer in mammals, and additionally a method to effectively treat cancer stem cells in mammals, with a composition comprised of one or more sea cucumber glycosides and Andrographolide, or an andrographolide analog.
• [EN] ISOLATION OF BIVITTOSIDE D FROM SEA CUCUMBER AND ACTIVITY THEREOF<br/>[FR] ISOLATION DE BIVITTOSIDE D À PARTIR D'HOLOTHURIE ET ACTIVITÉ DE LADITE SUBSTANCE
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2005063789A1

  公开（公告）日：2005-07-14

  The present invention provides a process for the isolation of Bivittoside-D, a triterpenoid saponin from the sea cucumber Bohadschia vitiensis and its potent spermicidal and fungicidal activity.
• Kitagawa, Isao; Kobayashi, Motomasa; Hori, Manabu, Chemical and pharmaceutical bulletin, 1989, vol. 37, # 1, p. 61 - 67
  作者：Kitagawa, Isao、Kobayashi, Motomasa、Hori, Manabu、Kyogoku, Yoshimasa

  DOI：——

  日期：——