methyl 13-ethyl-12-hydroxypodocarpa-8,11,13-trien-19-oate | 54973-19-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: methyl 13-ethyl-12-hydroxypodocarpa-8,11,13-trien-19-oate
• 英文别名: methyl (1S,4aS,10aR)-7-ethyl-6-hydroxy-1,4a-dimethyl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carboxylate
• CAS: 54973-19-2
• 化学式: C₂₀H₂₈O₃
• 分子量: 316.441
• InChiKey: UTXKMRGHLPEZJV-RLLQIKCJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl 13-ethyl-12-hydroxypodocarpa-8,11,13-trien-19-oate 在 palladium on activated charcoal 硝酸 、 乙酸酐 、 一水合肼 作用下， 以 乙醇 为溶剂， 反应 4.0h， 生成 methyl 11-amino-13-ethyl-12-hydroxypodocarpa-8,11,13-trien-19-oate
  参考文献：
  名称：

  Cambie, Richard C.; Grimsdale, Andrew C.; Rutledge, Peter S., Australian Journal of Chemistry, 1990, vol. 43, # 3, p. 485 - 501

  摘要：

  DOI：
• 作为产物：
  描述：

  methyl 13-acetyl-12-hydroxypodocarpa-8,11,13-trien-19-oate 在 盐酸 、 amalgamated zinc 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以91%的产率得到methyl 13-ethyl-12-hydroxypodocarpa-8,11,13-trien-19-oate
  参考文献：
  名称：

  Cambie, Richard C.; Grimsdale, Andrew C.; Rutledge, Peter S., Australian Journal of Chemistry, 1990, vol. 43, # 3, p. 485 - 501

  摘要：

  DOI：

文献信息

• Functionalisation of Alkylalkoxysilanes. Studies Towards Annulations of Diterpenoids
  作者：Paul W.R. Harris、Paul D. Woodgate

  DOI：10.1016/s0040-4020(00)00302-1

  日期：2000.6

  Ortho-(2-triethoxysilylethyl) derivatives of aryl ketones undergo oxidative desilylation with H2O2. Tetralone derivatives have served as model substrates for 14-2-(triethoxysilylethyl)-7-oxopodocarpanes, which have been converted into 2-arylethanols in a four-step sequence (BH3. BMS, H2O2, Et3SiH/CF3COOH, TBAF) without isolation of intermediate products (oxasilepin, diol, trifluoroacetate). Use of the 14-(2-diethoxysilylmethyl) analogue improved the overall yield significantly (75 versus 40%). Re-oxidation of ring B with CAN gave the Delta(5)-7-oxo derivative, which was converted into an enone-aldehyde by treatment with Collins' reagent. The conjugated alkene was reduced stereoselectively with SmI2, which, however, did not promote pinacol coupling of the resulting 1,5-keto aldehyde. (C) 2000 Elsevier Science Ltd. All rights reserved.
• CAMBIE, RICHARD C.;GRIMSDALE, ANDREW C.;RUTLEDGE, PETER S.;WOODGATE, PAUL+, AUSTRAL. J. CHEM., 43,(1990) N, C. 485-501
  作者：CAMBIE, RICHARD C.、GRIMSDALE, ANDREW C.、RUTLEDGE, PETER S.、WOODGATE, PAUL+

  DOI：——

  日期：——
• Cambie, Richard C.; Grimsdale, Andrew C.; Rutledge, Peter S., Australian Journal of Chemistry, 1990, vol. 43, # 3, p. 485 - 501
  作者：Cambie, Richard C.、Grimsdale, Andrew C.、Rutledge, Peter S.、Woodgate, Paul D.

  DOI：——

  日期：——