7-hydroxy-3-(2-methoxyphenyl)-8-[(4-methylpiperidin-1-yl)methyl]-4H-chromen-4-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: 7-hydroxy-3-(2-methoxyphenyl)-8-[(4-methylpiperidin-1-yl)methyl]-4H-chromen-4-one
• 英文别名: 3-(2-methoxyphenyl)-8-[(4-methylpiperidinium-1-yl)methyl]-4-oxo-4H-chromen-7-olate；3-(2-methoxyphenyl)-8-[(4-methylpiperidin-1-ium-1-yl)methyl]-4-oxochromen-7-olate
• 化学式: C₂₃H₂₅NO₄
• mdl: MFCD02071834
• 分子量: 379.456
• InChiKey: DIPBHKKCKVWICC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  59
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  7-羟基-3-（2-甲氧基苯基）-4H-苯并吡喃-4-酮 、 1,1'-亚甲基二(4-甲基哌啶) 以 1,4-二氧六环 为溶剂， 反应 1.0h， 以75%的产率得到7-hydroxy-3-(2-methoxyphenyl)-8-[(4-methylpiperidin-1-yl)methyl]-4H-chromen-4-one
  参考文献：
  名称：

  Synthesis of analogs of natural 2′-methoxyisoflavones

  摘要：

  2-(未)取代的2′-甲氧基-7-羟基异黄酮被合成。通过烷基化和酰基化反应以及曼尼希碱的形成，它们在酚羟基上进行了衍生化处理。

  DOI：

  10.1007/s10600-006-0063-0

文献信息

• [EN] INHIBITORS OF IRES PORTION OF AN ENTEROVIRUS<br/>[FR] INHIBITEURS DE LA PARTIE IRES D'UN ENTÉROVIRUS
  申请人：AGENCY SCIENCE TECH & RES

  公开号：WO2020022961A1

  公开（公告）日：2020-01-30

  The present invention relates to compositions for treating an enterovirus infection or an enterovirus induced disorder. In one aspect of the present invention, there is provided the use of a molecule such as flavonoid that inhibits or prevents an interaction between at least one IRES trans-acting factor (ITAF) and an IRES portion of an enterovirus for treating an enterovirus infection. In particular, a composition comprising prunin (ST077105) can suppress the human enterovirus 71 (HEVA71) in cell and murine models. Similar suppressive effect is also observed in cells infected with Hepatitis C virus and Coxsackie virus.
• Synthesis of analogs of natural 2′-methoxyisoflavones
  作者：M. S. Frasinyuk、S. P. Bondarenko、V. P. Khilya

  DOI：10.1007/s10600-006-0063-0

  日期：2006.3

  2-(Un)substituted-2′-methoxy-7-hydroxyisoflavones were synthesized. They were derivatized at the phenol hydroxyl using alkylation and acylation reactions and Mannich base formation.

  2-(未)取代的2′-甲氧基-7-羟基异黄酮被合成。通过烷基化和酰基化反应以及曼尼希碱的形成，它们在酚羟基上进行了衍生化处理。