O⁶-allyl-N²-[(allyloxy)carbonyl]guanosine | 243844-60-2

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: O⁶-allyl-N²-[(allyloxy)carbonyl]guanosine
• 英文别名: prop-2-enyl N-[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-prop-2-enoxypurin-2-yl]carbamate
• CAS: 243844-60-2
• 化学式: C₁₇H₂₁N₅O₇
• 分子量: 407.383
• InChiKey: GZFNMCFPTNNIAK-SDBHATRESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  29
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  161
• 氢给体数：
  4
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  O⁶-allyl-N²-[(allyloxy)carbonyl]guanosine 在 咪唑 作用下， 以 吡啶 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.5h， 生成 O⁶-allyl-N²-[(allyloxy)carbonyl]-5'-O-(p,p'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)guanosine
  参考文献：
  名称：

  Improved Methods for the Preparation of 2′-Deoxyribonucleoside and Ribonucleoside 3′-Phosphoramidites with Allylic Protectors

  摘要：

  Improved methods of preparing 2'-deoxyribonucleoside and ribonucleoside 3'-phosphoramidites with allylic protecting groups, which serve as useful building blocks, particularly for the synthesis of base-labile derivatives, are developed.

  DOI：

  10.1080/07328319908044842
• 作为产物：
  描述：

  2',3',5'-三乙酰鸟苷 在 sodium hydroxide 、 叔丁基氯化镁 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 乙醇 为溶剂， 反应 4.5h， 生成 O⁶-allyl-N²-[(allyloxy)carbonyl]guanosine
  参考文献：
  名称：

  Improved Methods for the Preparation of 2′-Deoxyribonucleoside and Ribonucleoside 3′-Phosphoramidites with Allylic Protectors

  摘要：

  Improved methods of preparing 2'-deoxyribonucleoside and ribonucleoside 3'-phosphoramidites with allylic protecting groups, which serve as useful building blocks, particularly for the synthesis of base-labile derivatives, are developed.

  DOI：

  10.1080/07328319908044842

文献信息

• Improved Methods for the Preparation of 2′-Deoxyribonucleoside and Ribonucleoside 3′-Phosphoramidites with Allylic Protectors
  作者：Sophie B. Heidenhain、Yoshihiro Hayakawa

  DOI：10.1080/07328319908044842

  日期：1999.8

  Improved methods of preparing 2'-deoxyribonucleoside and ribonucleoside 3'-phosphoramidites with allylic protecting groups, which serve as useful building blocks, particularly for the synthesis of base-labile derivatives, are developed.