3β,16α-dihydroxyolean-12-en-28-oic acid 28-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranoside) | 1438763-74-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3β,16α-dihydroxyolean-12-en-28-oic acid 28-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranoside)
• 英文别名: 3β,16α-dihydroxyoleanadine-12-en-28-oic acid 28-N-(2,3,4,6-tetra-O-acetyl-β-D-galactoside)；[(2S,3R,4S,5S,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl] (4aR,5R,6aR,6aS,6bR,8aR,10S,12aR,14bS)-5,10-dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate
• CAS: 1438763-74-6
• 化学式: C₄₄H₆₆O₁₃
• 分子量: 803.0
• InChiKey: WOJYIASDGWNODU-GTRPVUKHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  57
• 可旋转键数：
  12
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  181
• 氢给体数：
  2
• 氢受体数：
  13

反应信息

• 作为反应物：
  描述：

  3β,16α-dihydroxyolean-12-en-28-oic acid 28-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranoside) 在 甲醇 、 sodium methylate 作用下， 以99%的产率得到3β,16α-dihydroxyolean-12-en-28-oic acid 28-O-(β-D-galactoside)
  参考文献：
  名称：

  Development of Oleanane-Type Triterpenes as a New Class of HCV Entry Inhibitors

  摘要：

  Development of hepatitis C virus (HCV) entry inhibitors represents an emerging approach that satisfies a tandem mechanism for use with other inhibitors in a multifaceted cocktail. By screening Chinese herbal extracts, oleanolic acid (OA) was found to display weak potency to inhibit HCV entry with an IC50 of 10 mu M. Chemical exploration of this triterpene compound revealed its pharmacophore requirement for blocking HCV entry, rings A, B, and E, are conserved while ring D is tolerant of some modifications. Hydroxylation at C-16 significantly enhanced its potency for inhibiting HCV entry with IC50 at 1.4 mu M. Further modification by conjugation of this new lead with a disaccharide at 28-COOH removed the undesired hemolytic effect and, more importantly, increased its potency by similar to 5-fold (54a, IC50 0.3 mu M). Formation of a triterpene dimer via a linker bearing triazole (70) dramatically increased its potency with IC50 at similar to 10 nM. Mechanistically, such functional triterpenes interrupt the interaction between HCV envelope protein E2 and its receptor CD81 via binding to E2, thus blocking virus and host cell recognition. This study establishes the importance of triterpene natural products as new leads for the development of potential HCV entry inhibitors.

  DOI：

  10.1021/jm301910a
• 作为产物：
  描述：

  1,2,3,4,6-D-葡萄糖五乙酸酯 在 四丁基溴化铵 、 氢溴酸 、 potassium carbonate 、 溶剂黄146 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 24.0h， 生成 3β,16α-dihydroxyolean-12-en-28-oic acid 28-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranoside)
  参考文献：
  名称：

  TRITERPENE DERIVATIVE AND ITS ANTI-INFLUENZA USE

  摘要：

  公开号：

  EP2910563B1