2,7-Dimethoxyacridine-9-carbonyl chloride | 178920-78-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2,7-Dimethoxyacridine-9-carbonyl chloride
• CAS: 178920-78-0
• 化学式: C₁₆H₁₂ClNO₃
• 分子量: 301.729
• InChiKey: KMBCDHGEUXPRDO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  48.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,7-Dimethoxyacridine-9-carbonyl chloride 在 吡啶 、 水 、 三溴化硼 、 caesium carbonate 、 对甲苯磺酰氯 、 potassium hydroxide 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 177.17h， 生成 2,7-(OMHEG)2-2'-(CH2O[CH2CH2O]CH2CH2OMe)-4'-methoxycarbonylphenyl-6'-Me-acridine-9-carboxylate
  参考文献：
  名称：

  STABLE ACRIDINIUM ESTERS WITH FAST LIGHT EMISSION

  摘要：

  公开号：

  EP2074101B1
• 作为产物：
  描述：

  4,4'-二甲氧基二苯胺 在 aluminum (III) chloride 、 氯化亚砜 、 potassium hydroxide 作用下， 以 二氯甲烷 为溶剂， 生成 2,7-Dimethoxyacridine-9-carbonyl chloride
  参考文献：
  名称：

  甲氧羰基苯基-10-甲基10λ的化学发光4 -2,7-二取代的吖啶-9-羧酸酯衍生物

  摘要：

  甲氧羰基苯基-10-甲基10λ 4 -2,7-二取代的吖啶-9-羧酸酯衍生物的合成，并在pH 7-10既其化学发光的强度和它们的化学稳定性得到了澄清。评价了化学发光反应的产物和产生效率。4-（甲氧羰基）苯基-10-甲基10λ 4 -2,7- dimethylacridine -9-羧酸酯在pH 7-10，得到比较强的化学发光的强度和施加到过氧化氢的测量。

  DOI：

  10.1016/j.jphotochem.2020.112851

文献信息

• High Quantum Yield Acridinium Compounds and Their Uses in Improving Assay Sensitivity
  申请人：Natrajan Anand

  公开号：US20080014660A1

  公开（公告）日：2008-01-17

  The present invention relates to hydrophilic, high quantum yield acridinium compounds. It has been discovered that the placement of electron-donating groups in the acridinium ring system increases the amount of light that is emitted by the corresponding acridinium compound when its chemiluminescence is triggered by alkaline peroxide. More specifically, it has been found that the placement of one or two hydrophilic, alkoxy groups at the C-2 and/or C-7 position of the acridinium ring system of acridinium compounds increases their quantum yield and enhances the aqueous solubility of these compounds. The present hydrophilic, high quantum yield, acridinium compounds are useful chemiluminescent labels for improving the sensitivity of immunoassays.

  本发明涉及亲水性高量子产率的吖啶类化合物。已经发现，在吖啶环系中引入电子供体基团可以增加相应吖啶化合物在碱性过氧化物引发的化学发光时所发射的光量。更具体地，发现在吖啶环系的C-2和/或C-7位置引入一个或两个亲水性的烷氧基团可以增加吖啶类化合物的量子产率并提高这些化合物的水溶性。本发明的亲水性高量子产率的吖啶类化合物是用于提高免疫分析灵敏度的有用化学发光标记。
• Light-driven ion-pumping membrane systems
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US11318424B2

  公开（公告）日：2022-05-03

  Dye-sensitized ion-pumping membranes and methods of preparing said membranes are described herein. A regenerative and reversible photoactive dye is covalently-bonded to membrane or separator for ion-pumping. The photoactive dye-functionalized membranes can be arranged with other ion-exchange membranes, which serve as selective contacts to afford photovoltaic action and therefore form a power-producing membrane that pumps ions for use in driving an ion-exchange or ion-transport process, such as desalination and electrodialysis.

  本文描述了染料敏化离子泵膜和制备所述膜的方法。可再生和可逆的光敏染料与膜或分离器共价键合，用于离子泵。光敏染料功能化膜可与其他离子交换膜排列在一起，作为选择性接触以提供光生伏打作用，从而形成一种泵送离子的发电膜，用于驱动离子交换或离子传输过程，如海水淡化和电渗析。
• Simultaneous Quantification of Multiple Nucleic Acid Targets Using Chemiluminescent Probes
  作者：Kenneth A. Browne、Dimitri D. Deheyn、Gamal A. El-Hiti、Keith Smith、Ian Weeks

  DOI：10.1021/ja202221h

  日期：2011.9.21

  A novel method is described for simultaneous detection and quantification of attomoles or a few femtomoles of two (or potentially more) nucleic acid targets, without need for amplification. The technique depends on spectral-temporal resolution of chemiluminescence emitted from independent hybridization-induced chemiluminescent signal probes. The probes are internally quenched except in the presence of their specific targets, thereby allowing detection limits up to 10 000 times lower than with fluorescent probes. This is sufficient to obviate the need for amplification in many cases. The utility of the technique has been demonstrated by use of resolvable N-linked acridinium and 2,7-dimethoxy-acridinium ester labeled probes in a homogeneous assay for sensitive and simultaneous independent quantification of pan-bacterial and pan-fungal target sequences in seawater.
• HIGH QUANTUM YIELD ACRIDINIUM COMPOUNDS AND THEIR USES IN IMPROVING ASSAY SENSITIVITY
  申请人：Siemens Healthcare Diagnostics Inc.

  公开号：EP1946108B1

  公开（公告）日：2014-10-01
• US7309615B2
  申请人：——

  公开号：US7309615B2

  公开（公告）日：2007-12-18