3-(8-methoxy-2,3,5,6-tetrahydrobenzo[1,2-b;5,4-b']difuran-4-yl)acrylic acid benzyl ester | 926307-89-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 3-(8-methoxy-2,3,5,6-tetrahydrobenzo[1,2-b;5,4-b']difuran-4-yl)acrylic acid benzyl ester
• 英文别名: benzyl (E)-3-(8-methoxy-2,3,5,6-tetrahydrofuro[3,2-f][1]benzofuran-4-yl)prop-2-enoate
• CAS: 926307-89-3
• 化学式: C₂₁H₂₀O₅
• 分子量: 352.387
• InChiKey: LTSGXIKPOQWSLR-BQYQJAHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-(8-methoxy-2,3,5,6-tetrahydrobenzo[1,2-b;5,4-b']difuran-4-yl)acrylic acid benzyl ester 在 platinum on activated charcoal 二苯基膦叠氮化物 、 氢气 、 三乙胺 作用下， 以 乙醇 、 甲苯 为溶剂， 反应 30.0h， 生成 [2-(8-methoxy-2,3,5,6-tetrahydrobenzo[1,2-b;5,4-b']difuran-4-yl)ethyl]carbamic acid benzyl ester
  参考文献：
  名称：

  Synthesis of Tricyclic Heterocycles via a Tandem Aryl Alkylation/Heck Coupling Sequence

  摘要：

  A norbornene-mediated palladium-catalyzed sequence is described in which two alkyl-aryl bonds and one alkenyl-aryl bond are formed in one pot with use of microwave irradiation. A variety of symmetrical and unsymmetrical oxygen-, nitrogen-, silicon-, and sulfur-containing tricyclic heterocycles were synthesized from a Heck acceptor and an aryl iodide containing two tethered alkyl halides. This approach was further applied to the synthesis of a tricyclic mescaline analogue.

  DOI：

  10.1021/jo0617868
• 作为产物：
  描述：

  1,3,5-三碘-2-甲氧基苯 在 palladium diacetate 降冰片烯 、 正丁基锂 、 potassium carbonate 、 caesium carbonate 、 三苯基膦 作用下， 以 乙二醇二甲醚 、 乙醚 、 正己烷 、 丙酮 为溶剂， 反应 53.58h， 生成 3-(8-methoxy-2,3,5,6-tetrahydrobenzo[1,2-b;5,4-b']difuran-4-yl)acrylic acid benzyl ester
  参考文献：
  名称：

  Synthesis of Tricyclic Heterocycles via a Tandem Aryl Alkylation/Heck Coupling Sequence

  摘要：

  A norbornene-mediated palladium-catalyzed sequence is described in which two alkyl-aryl bonds and one alkenyl-aryl bond are formed in one pot with use of microwave irradiation. A variety of symmetrical and unsymmetrical oxygen-, nitrogen-, silicon-, and sulfur-containing tricyclic heterocycles were synthesized from a Heck acceptor and an aryl iodide containing two tethered alkyl halides. This approach was further applied to the synthesis of a tricyclic mescaline analogue.

  DOI：

  10.1021/jo0617868

文献信息

• Synthesis of Tricyclic Heterocycles via a Tandem Aryl Alkylation/Heck Coupling Sequence
  作者：Dino Alberico、Alena Rudolph、Mark Lautens

  DOI：10.1021/jo0617868

  日期：2007.2.1

  A norbornene-mediated palladium-catalyzed sequence is described in which two alkyl-aryl bonds and one alkenyl-aryl bond are formed in one pot with use of microwave irradiation. A variety of symmetrical and unsymmetrical oxygen-, nitrogen-, silicon-, and sulfur-containing tricyclic heterocycles were synthesized from a Heck acceptor and an aryl iodide containing two tethered alkyl halides. This approach was further applied to the synthesis of a tricyclic mescaline analogue.