The present inventions include a method of inhibiting COMT enzyme in a subject as well as compounds of formula I, or a pharmaceutically acceptable salt thereof, that are useful in the treatment of various disorders mediated by COMT, including Parkinson's disease and/or schizophrenia.
本发明包括一种抑制受试者体内 CO
MT 酶的方法,以及可用于治疗由 CO
MT 介导的各种疾病(包括帕
金森病和/或精神分裂症)的式 I 化合物或其药学上可接受的盐。