(R)-泛酸 | 470-29-1

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: (R)-泛酸
• 中文别名: 廣酸；泛解酸；2,4-二羟基-3,3-二甲基丁酸
• 英文名称: (+-)-2,4-dihydroxy-3,3-dimethyl-butyric acid
• 英文别名: α.γ-Dioxy-β.β-dimethyl-propan-α-carbonsaeure；α,γ-dihydroxy-β,β-dimethylbutyric acid；α.γ-Dihydroxy-β.β-dimethylbuttersaeure；(+/-)-2,4-Dihydroxy-3,3-dimethyl-buttersaeure；DL-2.4-Dihydroxy-3.3-dimethyl-buttersaeure；DL-2.4-dihydroxy-3.3-dimethyl-butyric acid；2.2-Dimethyl-butandiol-(1.3)-saeure-(4)；D,L-Pantoinsaeure；2,4-Dihydroxy-3,3-dimethylbutanoic acid
• CAS: 470-29-1
• 化学式: C₆H₁₂O₄
• mdl: MFCD19228104
• 分子量: 148.159
• InChiKey: OTOIIPJYVQJATP-UHFFFAOYSA-N

物化性质

• 熔点：
  124 °C
• 沸点：
  368.7±27.0 °C(Predicted)
• 密度：
  1.259±0.06 g/cm3(Predicted)
• 溶解度：
  甲醇（微溶）、水（微溶）

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

制备方法与用途

用途：混旋泛酸钙的中间体。

生产方法：通过将2,2-二甲基-3-羟基丙醛与氰化钠进行加成反应，生成2,2-二甲基-3-氰基丙二醇，随后水解得到目标产物。

反应信息

• 作为反应物：
  描述：

  (R)-泛酸 在 水 、 奎宁 作用下， 生成 (2S)-2,4-二羟基-3,3-二甲基丁酸
  参考文献：
  名称：

  Stiller et al., Journal of the American Chemical Society, 1940, vol. 62, p. 1788

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 barium dihydroxide 作用下， 生成 (R)-泛酸
  参考文献：
  名称：

  The Preparation and Properties of Sodium d-Pantothenate

  摘要：

  DOI：

  10.1021/ja01856a004

文献信息

• PHARMACEUTICAL COMPOSITION FOR RESPIRATORY ADMINISTRATION
  申请人：SEIKAGAKU CORPORATION

  公开号：US20160158369A1

  公开（公告）日：2016-06-09

  The present invention provides a pharmaceutical composition for respiratory administration containing a polysaccharide derivative having a group derived from a polysaccharide and a group derived from a physiologically active substance that is covalently bonded to the group derived from a polysaccharide.

  本发明提供了一种用于呼吸给药的药物组合物，其含有一个多糖衍生物，该多糖衍生物具有一个源自多糖的基团和一个源自生理活性物质的基团，该生理活性物质基团与源自多糖的基团共价结合。
• MASKED CARBOXYLATE NEOPENTYL SULFONYL ESTER CYCLIZATION RELEASE PRODRUGS OF ACAMPROSATE, COMPOSITIONS THEREOF, AND METHODS OF USE
  申请人：Jandeleit Bernd

  公开号：US20090069419A1

  公开（公告）日：2009-03-12

  Masked carboxylate neopentyl sulfonyl ester prodrugs of acamprosate, pharmaceutical compositions comprising such prodrugs, and methods of using such prodrugs and compositions thereof for treating diseases are disclosed. In particular, acamprosate prodrugs exhibiting enhanced oral bioavailability and methods of using acamprosate prodrugs to treat neurodegenerative disorders, psychotic disorders, mood disorders, anxiety disorders, somatoform disorders, movement disorders, substance abuse disorders, binge eating disorder, cortical spreading depression related disorders, tinnitus, sleeping disorders, multiple sclerosis, and pain are disclosed.

  掩蔽羧酸新戊磺酰酯丙戊酸酯前药，包含此类前药的药物组合物，以及使用此类前药和组合物治疗疾病的方法被披露。具体来说，披露了表现出增强口服生物利用度的丙戊酸酯前药和使用丙戊酸酯前药治疗神经退行性疾病、精神疾病、情绪障碍、焦虑障碍、躯体形式障碍、运动障碍、物质滥用障碍、暴饮暴食障碍、皮层扩散性抑郁相关障碍、耳鸣、睡眠障碍、多发性硬化症和疼痛的方法。
• [EN] PROCESS FOR PREPARATION OF OPTICALLY ACTIVE 1-ERYTHRO-2-AMINO-1-PHENYL-1-PROPANOL<br/>[FR] PROCEDE POUR PREPARER DU 1-ERYTHRO-2-AMINO-1-PHENYL-1-PROPANOL ACTIF DE MANIERE OPTIQUE
  申请人：EMMELLEN BIOTECH PHARMACEUTICA

  公开号：WO2005100299A1

  公开（公告）日：2005-10-27

  An efficient cost-effective process for preparation of l-erythro-2-amino-1-phenyl-1-propanol from l-1-phenyl-1-hydroxy-2-propanone, which comprises converting l-1-phenyl-1-hydroxy-2-propanone to l-1-phenyl-1-hydroxy-2-propanone oxime and reducing the oxime with a catalyst consisting of finely divided nickel and aluminium metals giving good diastereomeric purity and yield.

  从l-1-苯基-1-羟基-2-丙酮转化为l-1-苯基-1-羟基-2-丙酮肟，然后用由细分散的镍和铝金属组成的催化剂还原肟，从而高效、具有成本效益地制备l-erythro-2-氨基-1-苯基-1-丙醇的过程。
• GLYCOSAMINOGLYCAN DERIVATIVE AND METHOD FOR PRODUCING SAME
  申请人：SEIKAGAKU CORPORATION

  公开号：US20160151506A1

  公开（公告）日：2016-06-02

  The present invention provides a glycosaminoglycan derivative in which a group derived from glycosaminoglycan and a group derived from a physiologically active substance having at least one of a carboxy group and a hydroxy group are coupled by covalent bond with a spacer therebetween, in which the spacer is selected in accordance with the decomposition rate of the covalent bond to the group derived from the physiologically active substance.

  本发明提供了一种糖氨基聚糖衍生物，其中从糖氨基聚糖衍生的基团和从至少具有羧基或羟基之一的生理活性物质衍生的基团通过之间的间隔物以共价键偶联，其中该间隔物根据从生理活性物质衍生的基团的共价键的分解速率进行选择。
• Methods for treating of skin conditions with retinoid double conjugate compounds
  申请人：US COSMECEUTECHS LLC

  公开号：US10123960B2

  公开（公告）日：2018-11-13

  A double conjugate molecule made of a retinoid, an organic acid, particularly an a-hydroxy acid, and an alcohol or acyl group, is provided which is useful in treating skin conditions, particularly aging. The retinoid, organic acid, and alcohol/acyl group are preferably linked via ester bonds.

  提供一种由视黄醇、有机酸（特别是α-羟基酸）和醇或酰基组成的双共轭分子，可用于治疗皮肤状况，特别是衰老。视黄醇、有机酸和醇/酰基组最好通过酯键连接。