3-nitroquinolin-2(1H)-one | 103029-75-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-nitroquinolin-2(1H)-one
• 英文别名: 3-nitro-2(1H)-quinolone；3-nitro-1H-quinolin-2-one；3-Nitroquinolin-2-ol
• CAS: 103029-75-0
• 化学式: C₉H₆N₂O₃
• mdl: MFCD09754108
• 分子量: 190.158
• InChiKey: MZVAAWXYMDEDLD-UHFFFAOYSA-N

物化性质

• 熔点：
  260 °C
• 沸点：
  408.9±45.0 °C(Predicted)
• 密度：
  1.45±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  74.9
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 危险性防范说明：
  P264,P280,P302+P352,P305+P351+P338,P332+P313,P337+P313,P362
• 危险性描述：
  H315,H319
• 储存条件：
  室温

反应信息

• 作为反应物：
  描述：

  3-nitroquinolin-2(1H)-one 在 硫酸 、 硝酸 作用下， 生成 3,6,8-trinitro-quinolin-2-ol
  参考文献：
  名称：

  Ochiai et al., Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1958, vol. 78, p. 584,588

  摘要：

  DOI：
• 作为产物：
  描述：

  3-硝基-喹啉1-氧化物 在 乙酸酐 作用下， 生成 3-nitroquinolin-2(1H)-one
  参考文献：
  名称：

  Ochiai et al., Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1958, vol. 78, p. 584,588

  摘要：

  DOI：

文献信息

• 4-Imidazole derivatives of benzyl and restricted benzyl sulfonamides, sulfamides, ureas, carbamates, and amides and their use
  申请人：——

  公开号：US20030073850A1

  公开（公告）日：2003-04-17

  Compounds of formula I 1 are useful in treating diseases prevented by or ameliorated with &agr; 1A agonists. Also disclosed are &agr; 1A agonist compositions and a method of activating &agr; 1 adrenoceptors in a mammal.

  公式I的化合物在治疗由&agr; 1A激动剂预防或改善的疾病中很有用。还公开了&agr; 1A激动剂组合物和在哺乳动物中激活&agr; 1肾上腺素受体的方法。
• [EN] IMIDAZO[4,5-C]QUINOLINE DERIVATIVES AND USES THEREOF<br/>[FR] DÉRIVÉS D'IMIDAZO[4,5-C]QUINOLÉINE ET LEURS UTILISATIONS
  申请人：PIRAMAL ENTPR LTD

  公开号：WO2014141118A1

  公开（公告）日：2014-09-18

  The present invention relates to substituted imidazo[4,5-c]quinoline derivatives represented by the compounds formula (I), processes for their preparation, pharmaceutical compositions comprising said compounds and their use in the treatment of diseases or disorders mediated by one or more kinases (such as PI3 kinase, mTOR and ALK-1), particularly proliferative diseases or disorders such as cancer. The compounds of formula (I) can also be used in the treatment of inflammation, angiogenesis related disorders and bacterial infections.

  本发明涉及由化合物式(I)表示的取代咪唑并[4,5-c]喹啉衍生物，其制备方法，包含所述化合物的药物组合物以及它们在治疗由一个或多个激酶介导的疾病或紊乱（如PI3激酶、mTOR和ALK-1）中的用途，特别是增殖性疾病或紊乱，如癌症。化合物式(I)的化合物还可用于治疗炎症、血管生成相关紊乱和细菌感染。
• KYNURENINE PRODUCTION INHIBITOR
  申请人：Amishiro Nobuyoshi

  公开号：US20110237584A1

  公开（公告）日：2011-09-29

  Provided is a kynurenine production inhibitor comprising a nitrogen-containing heterocyclic compound represented by formula (I): (wherein R 50 and R 51 may be the same or different and each represent a hydrogen atom or the like, G 1 and G 2 may be the same or different and each represent a nitrogen atom or the like, X represents formula (III): (wherein m 1 and m 2 may be the same or different and each represent an integer of 0 or 1, Y represents an oxygen atom or the like, and R 6 and R 7 may be the same or different and each represent a hydrogen atom or the like), R 1 represents optionally substituted lower alkyl or the like, R 2 represents a hydrogen atom or the like, and R 3 represents optionally substituted lower alkyl or the like), and the like.

  提供的是一种色氨酸代谢抑制剂，包括由式(I)表示的含氮杂环化合物：（其中R50和R51可以相同也可以不同，每个代表氢原子或类似物，G1和G2可以相同也可以不同，每个代表氮原子或类似物，X表示式(III)：（其中m1和m2可以相同也可以不同，每个代表0或1的整数，Y表示氧原子或类似物，R6和R7可以相同也可以不同，每个代表氢原子或类似物），R1表示可选择地取代的低碳烷基或类似物，R2表示氢原子或类似物，R3表示可选择地取代的低碳烷基或类似物），等等。
• [EN] SUBSTITUTED IMIDAZOQUINOLINE DERIVATIVES AS KINASE INHIBITORS<br/>[FR] DÉRIVÉS D'IMIDAZOQUINOLINE SUBSTITUÉS À TITRE D'INHIBITEURS DE KINASES
  申请人：PIRAMAL LIFE SCIENCES LTD

  公开号：WO2012007926A1

  公开（公告）日：2012-01-19

  The present invention relates to substituted imidazo[4,5-c]quinoline derivatives, the compounds of formula (I), wherein R1 R2, R3, R4, R5, R6 and R7 are as defined in the specification, processes for their preparation, pharmaceutical compositions comprising compounds of formula (I), and their use in the treatment of diseases or disorders mediated by one or more kinases, particularly proliferative diseases or disorders such as cancer. These compounds can also be used in the treatment of inflammatory diseases and angiogenesis related disorders.

  本发明涉及取代咪唑并[4,5-c]喹啉衍生物，化合物的化学式为（I），其中R1、R2、R3、R4、R5、R6和R7如规范中定义，其制备方法，包括化合物（I）的药物组合物，以及它们在治疗由一个或多个激酶介导的疾病或紊乱中的用途，特别是增殖性疾病或紊乱，如癌症。这些化合物还可用于治疗炎症性疾病和与血管生成相关的紊乱。
• Pesticides
  申请人：——

  公开号：US05114940A1

  公开（公告）日：1992-05-19

  Compound of the formula (I) are disclosed ArQQ.sup.1 C(.dbd.X)NHR.sup.1 (I) or a salt thereof, wherein Ar is an optionally substituted polycyclic ring system containing n rings, where n is the integer 2 or 3, at least n-1 rings being aromatic and containing one to three ring nitrogen atoms and optionally containing one or more additional heteroatoms; Q is an alkyl chain containing 1 to 12 carbon atoms and optionally containing a sulphur or one or two oxygen atoms; Q.sup.1 is a group (C(R.sup.2).dbd.C(R.sup.3)).sub.a --(C(R.sup.4).dbd.C(R.sup.5)) wherein a is 0 or 1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are the same or different, at least two being hydrogen and the other two being independently selected from hydrogen, halo, C.sub.1-4 haloalkyl; X is oxygen or sulphur; and R.sup.1 is selected from hydrogen and C.sub.1-8 hydrocarbyl optionally substituted by dioxalanyl, halo, cyano, trifluoromethyl, trifluoromethylthio or C.sub.1-6 alkoxy are described which have activity particularly against arthropod pests. Pesticidal formulations containing the compounds of the formula (1), their use in the control of pests and method for their preparation are also disclosed.

  公式（I）的化合物ArQQ.sup.1 C(.dbd.X)NHR.sup.1（I）或其盐已被披露，其中Ar是一个含有n个环的可选择取代的多环环系，其中n是整数2或3，至少n-1个环是芳香的，含有一个到三个环氮原子，且可选择地含有一个或多个额外的杂原子；Q是一个含有1到12个碳原子的烷基链，可选择地含有一个硫或一个或两个氧原子；Q.sup.1是一个基团（C(R.sup.2).dbd.C(R.sup.3)).sub.a--(C(R.sup.4).dbd.C(R.sup.5))，其中a为0或1，R.sup.2，R.sup.3，R.sup.4和R.sup.5相同或不同，至少两个是氢，另外两个独立地选择自氢、卤素、C.sub.1-4卤代烷基；X是氧或硫；R.sup.1选择自氢和C.sub.1-8烃基，可选择地经二氧杂环戊二烯基、卤素、氰基、三氟甲基、三氟甲硫基或C.sub.1-6烷氧基取代的烃基所述，具有特别对节肢动物害虫具有活性。还披露了含有公式（1）的化合物的杀虫剂配方、它们在害虫控制中的使用以及它们的制备方法。