1-phenacyl-2-(2-chloroethylamino)benzimidazole | 154055-46-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-phenacyl-2-(2-chloroethylamino)benzimidazole
• 英文别名: 2-(2-chloroethylamino)-1-phenacylbenzimidazole；2-[2-(2-chloroethylamino)benzimidazol-1-yl]-1-phenylethanone
• CAS: 154055-46-6
• 化学式: C₁₇H₁₆ClN₃O
• 分子量: 313.787
• InChiKey: OXKGOORCLLAPFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  46.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-phenacyl-2-(2-chloroethylamino)benzimidazole 以88%的产率得到9-phenacyl-2,3-dihydroimidazo[1,2-a]benzimidazole
  参考文献：
  名称：

  Benzimidazole compounds

  摘要：

  本发明公开了通式(I)的化合物：##STR1## 其中，A、B、C、D、n、R.sub.1、R.sub.2、R.sub.3、R.sub.4、X、Y和Z如描述中所定义，并公开了它们作为抗糖尿病药物的用途。

  公开号：

  US05623073A1
• 作为产物：
  描述：

  1-phenacyl-2-(2-chloroethylamino)benzimidazole hydrochloride 在 ammonium hydroxide 作用下， 以 水 为溶剂， 以87%的产率得到1-phenacyl-2-(2-chloroethylamino)benzimidazole
  参考文献：
  名称：

  Research in the field of imidazo[1,2-a]benzimidazole derivatives: XXVII. 1-acylmethyl-2-(ω-hydroxyalkylamino)-benzimidazoles and their transformation into derivatives of tricyclic systems

  摘要：

  1-Acylmethyl-2-(omega-hydroxyalkylamino)benzimidazoles were synthesized and their behavior under various conditions was investigated: at the thermolysis without solvent, at heating in DMF or in 2-aminoethanol, hydrohalic acids, and acetic anhydride, in the presence of chlorinating agents (SOCl(2), POCl(3)). Depending on the reaction conditions derivatives were obtained of 1H-imidazo[1,2-a]-benzimidazole, 9H-2,3-dihydroimidazo[1,2-a]benzimidazole, and 10H-2,3,4,10-tetrahydropyrimido[1,2-a]-benzimidazole that were suitable synthons for the synthesis of functionally substituted derivatives of these tricyclic systems.

  DOI：

  10.1134/s1070428010020223

文献信息

• Dérivés du benzimidazole à activité antidiabétique et antiagrégante plaquettaire
  申请人：ADIR ET COMPAGNIE

  公开号：EP0571253A1

  公开（公告）日：1993-11-24

  Dérivés de formule générale (I) : où A, B, C, D, n, R₁, R₂, R₃, R₄, X, Y, Z sont tels que définis dans la description. Médicaments.

  通式(I)的衍生物 ： 其中 A、B、C、D、n、R₁、R₂、R₃、R₄、X、Y、Z 如描述中所定义。 药物。
• US5623073A
  申请人：——

  公开号：US5623073A

  公开（公告）日：1997-04-22
• US5639756A
  申请人：——

  公开号：US5639756A

  公开（公告）日：1997-06-17
• Research in the field of imidazo[1,2-a]benzimidazole derivatives: XXVII. 1-acylmethyl-2-(ω-hydroxyalkylamino)-benzimidazoles and their transformation into derivatives of tricyclic systems
  作者：V. A. Anisimova、I. E. Tolpygin、G. S. Borodkin

  DOI：10.1134/s1070428010020223

  日期：2010.2

  1-Acylmethyl-2-(omega-hydroxyalkylamino)benzimidazoles were synthesized and their behavior under various conditions was investigated: at the thermolysis without solvent, at heating in DMF or in 2-aminoethanol, hydrohalic acids, and acetic anhydride, in the presence of chlorinating agents (SOCl(2), POCl(3)). Depending on the reaction conditions derivatives were obtained of 1H-imidazo[1,2-a]-benzimidazole, 9H-2,3-dihydroimidazo[1,2-a]benzimidazole, and 10H-2,3,4,10-tetrahydropyrimido[1,2-a]-benzimidazole that were suitable synthons for the synthesis of functionally substituted derivatives of these tricyclic systems.
• Benzimidazole compounds
  申请人：Adir Et Compagnie

  公开号：US05623073A1

  公开（公告）日：1997-04-22

  Compounds of the general formula (I): ##STR1## wherein A, B, C, D, n, R.sub.1, R.sub.2, R.sub.3, R.sub.4, X, Y and Z are as defined in the description, and their use as antidiabetics are disclosed.

  本发明公开了通式(I)的化合物：##STR1## 其中，A、B、C、D、n、R.sub.1、R.sub.2、R.sub.3、R.sub.4、X、Y和Z如描述中所定义，并公开了它们作为抗糖尿病药物的用途。