二苯基-1-芘基膦 | 110231-30-6

• 物质功能分类: 有机原料 - 有机膦化合物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 二苯基-1-芘基膦
• 英文名称: diphenyl-1-pyrenylphosphine
• 英文别名: 1-(diphenylphosphino)pyrene；diphenyl(1-pyrenyl)phosphane；DPPP；diphenyl(pyren-1-yl)phosphane
• CAS: 110231-30-6
• 化学式: C₂₈H₁₉P
• 分子量: 386.433
• InChiKey: DSYGKYCYNVHCNQ-UHFFFAOYSA-N

物化性质

• 熔点：
  174.0 to 178.0 °C
• 沸点：
  551.5±19.0 °C(Predicted)
• 溶解度：
  DMF：10mg/mL；二氯甲烷：1mg/mL

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

安全信息

• 海关编码：
  2931900090
• 危险性防范说明：
  P264,P280,P302+P352+P332+P313+P362+P364,P305+P351+P338+P337+P313
• 危险性描述：
  H315,H319
• 储存条件：
  0-10°C

SDS

Diphenyl-1-pyrenylphosphine Revision number: 5
SAFETY DATA SHEET

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Section 1. IDENTIFICATION
Product name: Diphenyl-1-pyrenylphosphine

Revision number: 5

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Section 2. HAZARDS IDENTIFICATION
GHS classification
PHYSICAL HAZARDS Not classified
HEALTH HAZARDS
Skin corrosion/irritation Category 2
Category 2A
Serious eye damage/eye irritation
ENVIRONMENTAL HAZARDS Not classified
GHS label elements, including precautionary statements
Pictograms or hazard symbols
Signal word Warning
Hazard statements Causes skin irritation
Causes serious eye irritation
Precautionary statements:
Wash hands thoroughly after handling.
[Prevention]
Wear protective gloves/eye protection/face protection.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses,
[Response]
if present and easy to do. Continue rinsing.
If eye irritation persists: Get medical advice/attention.
IF ON SKIN: Gently wash with plenty of soap and water.
If skin irritation occurs: Get medical advice/attention.
Take off contaminated clothing and wash before reuse.

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Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substance/mixture: Substance
Components: Diphenyl-1-pyrenylphosphine
Percent: >95.0%(GC)
CAS Number: 110231-30-6
Synonyms: 1-(Diphenylphosphino)pyrene , DPPP
C28H19P
Chemical Formula:

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Section 4. FIRST AID MEASURES
Inhalation: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Get medical advice/attention if you feel unwell.
Diphenyl-1-pyrenylphosphine

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Section 4. FIRST AID MEASURES
Skin contact: Remove/Take off immediately all contaminated clothing. Gently wash with plenty of
soap and water. If skin irritation or rash occurs: Get medical advice/attention.
Eye contact: Rinse cautiously with water for several minutes. Remove contact lenses, if present
and easy to do. Continue rinsing. If eye irritation persists: Get medical
advice/attention.
Ingestion: Get medical advice/attention if you feel unwell. Rinse mouth.
A rescuer should wear personal protective equipment, such as rubber gloves and air-
Protection of first-aiders:
tight goggles.

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Section 5. FIRE-FIGHTING MEASURES
Suitable extinguishing Dry chemical, foam, water spray, carbon dioxide.
media:
Specific hazards arising Take care as it may decompose upon combustion or in high temperatures to
from the chemical: generate poisonous fume.
Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing
method according to the surrounding situation is used. Uninvolved persons should
evacuate to a safe place. In case of fire in the surroundings: Remove movable
containers if safe to do so.
Special protective When extinguishing fire, be sure to wear personal protective equipment.
equipment for firefighters:

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Section 6. ACCIDENTAL RELEASE MEASURES
Personal precautions, Use personal protective equipment. Keep people away from and upwind of spill/leak.
protective equipment and Entry to non-involved personnel should be controlled around the leakage area by
emergency procedures: roping off, etc.
Environmental precautions: Prevent product from entering drains.
Methods and materials for Sweep dust to collect it into an airtight container, taking care not to disperse it.
containment and cleaning Adhered or collected material should be promptly disposed of, in accordance with
up: appropriate laws and regulations.

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Section 7. HANDLING AND STORAGE
Precautions for safe handling
Technical measures: Handling is performed in a well ventilated place. Wear suitable protective equipment.
Prevent dispersion of dust. Wash hands and face thoroughly after handling.
Use a local exhaust if dust or aerosol will be generated.
Advice on safe handling: Avoid contact with skin, eyes and clothing.
Conditions for safe storage, including any
incompatibilities
Storage conditions: Keep container tightly closed. Store in a refrigerator.
Store away from incompatible materials such as oxidizing agents.
Heat-sensitive
Packaging material: Comply with laws.

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Section 8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Install a closed system or local exhaust as possible so that workers should not be
Engineering controls:
exposed directly. Also install safety shower and eye bath.
Personal protective equipment
Respiratory protection: Dust respirator. Follow local and national regulations.
Protective gloves.
Hand protection:
Eye protection: Safety glasses. A face-shield, if the situation requires.
Skin and body protection: Protective clothing. Protective boots, if the situation requires.

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Physical state (20°C): Solid
Form: Crystal- Powder
Slightly pale yellow - Yellow green
Colour:
Diphenyl-1-pyrenylphosphine

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Odour: No data available
pH: No data available
Melting point/freezing point:176°C
Boiling point/range: No data available
Flash point: No data available
Flammability or explosive
limits:
Lower: No data available
Upper: No data available
Relative density: No data available
Solubility(ies):
[Water] No data available
[Other solvents] No data available

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Section 10. STABILITY AND REACTIVITY
Chemical stability: Stable under proper conditions.
Possibility of hazardous No special reactivity has been reported.
reactions:
Incompatible materials: Oxidizing agents
Hazardous decomposition Carbon monoxide, Carbon dioxide, Phosphorus oxides
products:

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Section 11. TOXICOLOGICAL INFORMATION
Acute Toxicity: No data available
Skin corrosion/irritation: No data available
Serious eye No data available
damage/irritation:
Germ cell mutagenicity: No data available
Carcinogenicity:
IARC = No data available
NTP = No data available
Reproductive toxicity: No data available

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Section 12. ECOLOGICAL INFORMATION
Ecotoxicity:
Fish: No data available
Crustacea: No data available
No data available
Algae:
Persistence / degradability: No data available
No data available
Bioaccumulative
potential(BCF):
Mobility in soil
Log Pow: No data available
Soil adsorption (Koc): No data available
Henry's Law No data available
constant(PaM3/mol):

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Section 13. DISPOSAL CONSIDERATIONS
Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material
with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system.
Observe all federal, state and local regulations when disposing of the substance.

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Section 14. TRANSPORT INFORMATION
Hazards Class: Does not correspond to the classification standard of the United Nations
UN-No: Not listed
Diphenyl-1-pyrenylphosphine

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Section 15. REGULATORY INFORMATION
Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002
and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport,
loading and unloading were prescribed.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

二苯基-1-芘基膦（DPPP）是一种含氟过氧化物反应探针，展现出独特的光触发下聚集诱导发射（AIE）/聚集诱导猝灭（ACQ）转变，并具有显著的三阶非线性光信号变化[1]。

反应信息

• 作为反应物：
  描述：

  二苯基-1-芘基膦 在 双氧水 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 以1.8 g的产率得到diphenyl(1-pyrenyl)phosphorus oxide
  参考文献：
  名称：

  Thermally populated “bright” states for wide-range and high temperature sensing in air

  摘要：

  利用热力学上更明亮的激发态，已经开发出了用于空气中广泛范围和高温度感应的有机传感器。

  DOI：

  10.1039/c7cc00551b
• 作为产物：
  描述：

  三苯基膦 生成 二苯基-1-芘基膦
  参考文献：
  名称：

  MEGURO, HIROSHI;OHRUI, HIROSHI;AKASAKA, KAZUAKI

  摘要：

  DOI：
• 作为试剂：
  描述：

  2-甲基-3-硝基苯甲酸 在 sodium tetrahydroborate 、 N-溴代丁二酰亚胺(NBS) 、 硫酸 、 三氟化硼乙醚 、 水 、 palladium diacetate 、 碳酸氢铵 、 三乙胺 、 N,N-二异丙基乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 、 lithium hydroxide 、 二苯基-1-芘基膦 作用下， 以 四氢呋喃 、 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 45.5h， 生成 (S)-tertbutyl 4-(5-carbamoyl-3-(5-chloro-6-methylnicotinamido)-2-methylbenzyl)-2-methylpiperazine-1-carboxylate
  参考文献：
  名称：

  [EN] NOVEL COMPOUNDS
  [FR] NOUVEAUX COMPOSÉS

  摘要：

  揭示了新型视黄醇相关孤儿受体γ（RORγ）调节剂及其在通过RORγ介导的疾病治疗中的应用。

  公开号：

  WO2015180612A1

文献信息

• [EN] PRODRUGS OF ALOX-15 INHIBITORS AND METHODS OF USING THE SAME<br/>[FR] PROMÉDICAMENTS D'INHIBITEURS DE L'ALOX-15 ET LEURS PROCÉDÉS D'UTILISATION
  申请人：EMPIRICO INC

  公开号：WO2020150265A1

  公开（公告）日：2020-07-23

  Described herein are compounds and pharmaceutical compositions containing such compounds which are prodrugs of ALOX-15 inhibitors. Also described herein are methods for using such compounds in the treatment of disease.

  本文描述了一些化合物和含有这些化合物的药物组合物，这些化合物是ALOX-15抑制剂的前药。本文还描述了使用这些化合物治疗疾病的方法。
• 一种有机电致发光材料及其有机发光器件
  申请人：长春海谱润斯科技有限公司

  公开号：CN108264521A

  公开（公告）日：2018-07-10

  本发明提供一种有机电致发光材料及有机发光器件，属于有机光电材料技术领域。本发明提供的有机电致发光材料的结构中含有芘的结构，通过连接芳基硅基、芳基膦氧基、芳基砜基基团，有效地打断了共轭结构，使得三线态能级更高。同时，本发明提供的有机电致发光材料的结构中含有的强的吸电子基团，使得其具有优异的电子传输能力，可以作为发光层材料或电子传输层材料应用于有机发光器件中，具有更高的发光效率和更低的驱动电压。
• PHOSPHINE COMPOUND, PROCESS FOR PRODUCING THE SAME, AND PEROXIDE SCAVENGER USING THE SAME
  申请人：Shioji Kosei

  公开号：US20110015440A1

  公开（公告）日：2011-01-20

  The invention provides a novel peroxide scavenger comprising a phosphine compound represented by general formula [I]: wherein Z 1 and Z 2 each represents a cyclic group; Ar represents an arylene group; R represents an aliphatic hydrocarbon group; Y represents phosphorus (P), nitrogen (N), or bismuth (Bi); and R 1 , R 2 , and R 3 each represents a cyclic group, particularly a peroxide scavenger that can scavenge peroxides such as reactive oxygen species which are generated in mitochondria upon exposure to oxidative stress and localized in mitochondria. The phosphine compound of the invention is oxidized by the peroxides localized in mitochondria to increase the fluorescence intensity, whereby the peroxides can be scavenged.

  该发明提供了一种新型过氧化物清除剂，包括由通式[I]所表示的膦化合物：其中Z1和Z2分别表示环状基团；Ar表示芳基基团；R表示脂肪烃基团；Y表示磷（P）、氮（N）或铋（Bi）；而R1、R2和R3分别表示环状基团，特别是一种过氧化物清除剂，可以清除在暴露于氧化应激时在线粒体中生成并定位在线粒体中的反应性氧化物种，该发明的膦化合物被定位在线粒体中的过氧化物氧化以增加荧光强度，从而可以清除过氧化物。
• (METH)ACRYLATE MANUFACTURING METHOD
  申请人：TOAGOSEI CO., LTD

  公开号：US20180118658A1

  公开（公告）日：2018-05-03

  The present invention provides a (meth)acrylate manufacturing method characterized in that when manufacturing a (meth) acrylate by an ester exchange reaction between an alcohol and a monofunctional (meth)acrylate using catalyst A and catalyst B together, contact treatment of the ester exchange reaction product with adsorbent C is performed. Catalyst A: One or more kinds of compounds selected from a group consisting of cyclic tertiary amines with an azabicyclo structure and salts or complexes thereof, amidine and salts or complexes thereof, compounds with a pyridine ring and salts or complexes thereof, phosphines and salts or complexes thereof, and compounds with a tertiary diamine structure and salts or complexes thereof. Catalyst B: One or more kinds of compounds selected from a group consisting of compounds comprising zinc. Adsorbent C: One or more kinds of compounds selected from a group consisting of oxides and hydroxides comprising at least one of magnesium, aluminum and silicon.

  本发明提供了一种（甲基）丙烯酸酯制备方法，其特征在于通过在使用催化剂A和催化剂B一起进行醇和单官能基（甲基）丙烯酸酯之间的酯交换反应制备（甲基）丙烯酸酯时，对酯交换反应产物进行与吸附剂C的接触处理。催化剂A：从含有氮杂双环结构的环状三级胺及其盐或络合物、胺嘧啶及其盐或络合物、含有吡啶环的化合物及其盐或络合物、膦及其盐或络合物、以及含有三级二胺结构的化合物及其盐或络合物中选择的一种或多种化合物。催化剂B：从含锌化合物中选择的一种或多种化合物。吸附剂C：从含有镁、铝和硅中至少一种的氧化物和氢氧化物中选择的一种或多种化合物。
• Dihydroxyphenyl compounds and glucoside compounds thereof
  申请人：——

  公开号：US20030017997A1

  公开（公告）日：2003-01-23

  The present invention is a compound represented by the following formula (1) or (2): 1 where one of R 1 and R 2 is hydrogen and the other one is hydrogen or glucose residue. The compound is effective for reforming obese constitution, suppressing or preventing obesity. It is also effective for skin whitening.

  本发明是由以下式（1）或（2）表示的化合物： 其中R1和R2中的一个是氢，另一个是氢或葡萄糖残基。该化合物对改善肥胖体质、抑制或预防肥胖具有有效作用。同时，它也对美白皮肤有效。