p-tolyl 2-azido-6-O-(tert-butyldiphenylsilyl)-1,2-deoxy-3-levulinoyl-4-O-(p-methoxybenzyl)-1-thio-β-D-glucopyranoside | 870001-62-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: p-tolyl 2-azido-6-O-(tert-butyldiphenylsilyl)-1,2-deoxy-3-levulinoyl-4-O-(p-methoxybenzyl)-1-thio-β-D-glucopyranoside
• 英文别名: [(2R,3S,4R,5R,6S)-5-azido-2-[[tert-butyl(diphenyl)silyl]oxymethyl]-3-[(4-methoxyphenyl)methoxy]-6-(4-methylphenyl)sulfanyloxan-4-yl] 4-oxopentanoate
• CAS: 870001-62-0
• 化学式: C₄₂H₄₉N₃O₇SSi
• 分子量: 768.018
• InChiKey: JPLMOUOLSJUTLM-NMFAXJMVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.94
• 重原子数：
  54
• 可旋转键数：
  18
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  120
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  p-tolyl 2-azido-6-O-(tert-butyldiphenylsilyl)-1,2-deoxy-3-levulinoyl-4-O-(p-methoxybenzyl)-1-thio-β-D-glucopyranoside 在 2,6-二叔丁基-4-甲基吡啶 1-(苯基亚硫酰基)哌啶 、 三氟甲磺酸酐 、 4 A molecular sieve 、 magnesium bromide 作用下， 以 乙醚 、 硝基甲烷 、 二氯甲烷 为溶剂， 反应 32.0h， 生成 (2S,3S,4S,5R,6S)-5-Acetoxy-3-[(2R,3R,4R,5S,6R)-3-azido-6-(tert-butyl-diphenyl-silanyloxymethyl)-5-(4-methoxy-benzyloxy)-4-(4-oxo-pentanoyloxy)-tetrahydro-pyran-2-yloxy]-4-hydroxy-6-methoxy-tetrahydro-pyran-2-carboxylic acid methyl ester
  参考文献：
  名称：

  Orthogonal Sulfation Strategy for Synthetic Heparan Sulfate Ligands

  摘要：

  An orthogonal sulfation strategy involving six different protecting groups has been developed for generating sulfated carbohydrate libraries based on heparan. Chemoselective cleavage conditions (optimized for a heparan disaccharide) can be performed in the presence of sulfate esters as well as the remaining protecting groups.

  DOI：

  10.1021/ol052130o
• 作为产物：
  描述：

  Acetic acid (2S,3R,4R,5S,6R)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-6-hydroxymethyl-5-(4-methoxy-benzyloxy)-2-p-tolylsulfanyl-tetrahydro-pyran-4-yl ester 在 咪唑 、 4-二甲氨基吡啶 、 triflic azide 、 sodium methylate 、 potassium carbonate 、 copper(II) sulfate 、 乙二胺 、 N,N'-二环己基碳二亚胺 作用下， 以 甲醇 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 、 正丁醇 为溶剂， 反应 93.0h， 生成 p-tolyl 2-azido-6-O-(tert-butyldiphenylsilyl)-1,2-deoxy-3-levulinoyl-4-O-(p-methoxybenzyl)-1-thio-β-D-glucopyranoside
  参考文献：
  名称：

  Orthogonal Sulfation Strategy for Synthetic Heparan Sulfate Ligands

  摘要：

  An orthogonal sulfation strategy involving six different protecting groups has been developed for generating sulfated carbohydrate libraries based on heparan. Chemoselective cleavage conditions (optimized for a heparan disaccharide) can be performed in the presence of sulfate esters as well as the remaining protecting groups.

  DOI：

  10.1021/ol052130o

文献信息

• Orthogonal Sulfation Strategy for Synthetic Heparan Sulfate Ligands
  作者：Ren-Hua Fan、Jihane Achkar、Jesús M. Hernández-Torres、Alexander Wei

  DOI：10.1021/ol052130o

  日期：2005.10.1

  An orthogonal sulfation strategy involving six different protecting groups has been developed for generating sulfated carbohydrate libraries based on heparan. Chemoselective cleavage conditions (optimized for a heparan disaccharide) can be performed in the presence of sulfate esters as well as the remaining protecting groups.