(S)-tert-butyl 1-(2-chloro-7-fluoro-8-methylquinolin-3-yl)ethylcarbamate | 1240186-22-4
中文名称
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中文别名
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英文名称
(S)-tert-butyl 1-(2-chloro-7-fluoro-8-methylquinolin-3-yl)ethylcarbamate
英文别名
(S)-tert-butyl 1-(2-chloro-7-fluoro-8-methylquinolin-3-yl)ethylcarbarnate；tert-butyl N-[(1S)-1-(2-chloro-7-fluoro-8-methylquinolin-3-yl)ethyl]carbamate
CAS
1240186-22-4
化学式
C17H20ClFN2O2
mdl
——
分子量
338.809
InChiKey
QUOAVHQLVUWGEJ-JTQLQIEISA-N
BEILSTEIN
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EINECS
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物化性质
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计算性质
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ADMET
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安全信息
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SDS
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制备方法与用途
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上下游信息
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文献信息
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表征谱图
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同类化合物
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相关功能分类
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相关结构分类
物化性质
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沸点：465.1±45.0 °C(Predicted)
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密度：1.220±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
计算性质
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辛醇/水分配系数(LogP)：4.5
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重原子数：23
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可旋转键数：4
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环数：2.0
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sp3杂化的碳原子比例：0.41
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拓扑面积：51.2
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氢给体数：1
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氢受体数：4
上下游信息
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下游产品
中文名称 英文名称 CAS号 化学式 分子量 —— (S)-1-(2-chloro-7-fluoro-8-methylquinolin-3-yl)ethanamine 1305350-03-1 C12H12ClFN2 238.692 —— (S)-tert-butyl 1-[7-fluoro-2-(isopropylthio)-8-methylquinolin-3-yl]ethylcarbamate 1307298-77-6 C20H27FN2O2S 378.511 —— (S)-tert-butyl 1-[2-(2-amino-2-oxoethylthio)-7-fluoro-8-methylquinolin-3-yl]ethylcarbamate 1307298-76-5 C19H24FN3O3S 393.482 —— (S)-tert-butyl 1-[7-fluoro-8-methyl-2-(pyrrolidin-1-yl)quinolin-3-yl]ethylcarbamate 1242180-61-5 C21H28FN3O2 373.471 —— tert-butyl ((1S)-1-(2-((2,3-dihydroxypropyl)thio)-7-fluoro-8-methylquinolin-3-yl)ethyl)carbamate 1307298-88-9 C20H27FN2O4S 410.51 —— tert-butyl (S)-(1-(7-fluoro-8-methyl-2-((tetrahydro-2H-pyran-4-yl)amino)quinolin-3-yl)ethyl)carbamate 1240187-17-0 C22H30FN3O3 403.497 —— tert-butyl (S)-(1-(7-fluoro-2-(4-isopropylpiperazin-1-yl)-8-methylquinolin-3-yl)ethyl)carbamate 1242181-12-9 C24H35FN4O2 430.566 —— (S)-tert-butyl 1-{7-fluoro-8-methyl-2-[4-(pyridin-2-yl)piperazin-1-yl]quinolin-3-yl}ethylcarbamate 1256280-37-1 C26H32FN5O2 465.571 —— (S)-tert-butyl 1-{7-fluoro-8-methyl-2-[4-(2,2,2-trifluoroethyl)piperazin-1-yl]quinolin-3-yl}ethylcarbamate 1242180-66-0 C23H30F4N4O2 470.51 —— (S)-tert-butyl 1-[2-(4-acetylpiperazin-1-yl)-7-fluoro-8-methylquinolin-3-yl]ethylcarbarnate 1306784-51-9 C23H31FN4O3 430.523 —— (S)-tert-butyl 1-[2-(4-carbamoylpiperidin-1-yl)-7-fluoro-8-methylquinolin-3-yl] ethylcarbamate 1242180-65-9 C23H31FN4O3 430.523 —— (S)-tert-butyl 1-(2-{4-[2-(dimethylamino)-2-oxoethyl]piperazin-1-yl}-7-fluoro-8-methylquinolin-3-yl)ethylcarbamate 1256280-35-9 C25H36FN5O3 473.591 —— tert-butyl (S)-(1-(2-(4-carbamoylpiperazin-1-yl)-7-fluoro-8-methylquinolin-3-yl)ethyl)carbamate 1256280-24-6 C22H30FN5O3 431.51 —— (S)-methyl 4-{3-[1-(tert-butoxycarbonylamino)ethyl]-7-fluoro-8-methylquinolin-2-yl}piperazine-1-carboxylate 1242181-06-1 C23H31FN4O4 446.522 —— tert-butyl (S)-1-{2-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-7-fluoro-8-methylquinolin-3-yl}ethylcarbamate 1242180-68-2 C23H33FN4O2 416.539 —— tert-butyl (S)-(1-(2-(4-(dimethylglycyl)piperazin-1-yl)-7-fluoro-8-methylquinolin-3-yl)ethyl)carbamate 1256280-62-2 C25H36FN5O3 473.591 —— (S)-tert-butyl 1-{7-fluoro-2-[4-(2-hydroxyacetyl)piperezin-1-yl]-8-methylquinolin-3-yl}ethylcarbamate 1242180-63-7 C23H31FN4O4 446.522 —— (S)-tert-butyl 1-[7-fluoro-8-methyl-2-(4-pivaloylpiperazin-1-yl)quinolin-3-yl]ethylcarbamate 1242180-73-9 C26H37FN4O3 472.603 —— tert-butyl (S)-(1-(2-(4-(cyclopropanecarbonyl)piperazin-1-yl)-7-fluoro-8-methylquinolin-3-yl)ethyl)carbamate 1256280-39-3 C25H33FN4O3 456.56 —— tert-butyl (S)-1-{2-[(R)-3-acetamidopyrrolidin-1-yl]-7-fluoro-8-methylquinolin-3-yl}ethyl carbamate 1242180-82-0 C23H31FN4O3 430.523 —— (S)-N-[1-(2-chloro-7-fluoro-8-methylquinolin-3-yl)ethyl]pyrrolo[2,1-a][1,2,4]triazin-4-amine 1305350-04-2 C18H15ClFN5 355.802 —— tert-butyl ((S)-1-(2-((S)-3-(cyclopropanecarboxamido)pyrrolidin-1-yl)-7-fluoro-8-methylquinolin-3-yl)ethyl)carbamate 1256280-52-0 C25H33FN4O3 456.56 —— methyl (S)-4-(3-(1-aminoethyl)-7-fluoro-8-methylquinolin-2-yl)piperazine-1-carboxylate 1242181-07-2 C18H23FN4O2 346.405 —— 2-[3-[(1S)-1-aminoethyl]-7-fluoro-8-methylquinolin-2-yl]sulfanylethanol 1307298-86-7 C14H17FN2OS 280.366 —— (S)-4-[3-(1-aminoethyl)-7-fluoro-8-methylquinolin-2-yl]piperazine-1-carboxamide 1256280-22-4 C17H22FN5O 331.393 —— (S)-4-(3-(1-aminoethyl)-7-fluoro-8-methylquinolin-2-yl)-N-methylpiperazine-1-carboxamide 1256280-51-9 C18H24FN5O 345.42 —— (S)-1-{4-[3-(1-aminoethyl)-7-fluoro-8-methylquinolin-2-yl]piperazin-1-yl}ethanone 1256280-15-5 C18H23FN4O 330.405 —— 2-[3-[(1S)-1-aminoethyl]-7-fluoro-8-methylquinolin-2-yl]sulfanylacetamide 1307298-83-4 C14H16FN3OS 293.365 —— (S)-(4-(3-(1-aminoethyl)-7-fluoro-8-methylquinolin-2-yl)piperazin-1-yl)(cyclopropyl)methanone 1306784-76-8 C20H25FN4O 356.443 —— 2-[(3-{(1S)-1-[(4-amino-5-cyanopyrimidin-2-yl)amino]ethyl}-7-fluoro-8-methyl-quinolin-2-yl)sulfanyl]-N-methylacetamide 1307298-98-1 C20H20FN7OS 425.49 —— (S)-methyl 4-{7-fluoro-8-methyl-3-[1-(pyrido[2,3-d]pyrimidin-4-ylamino)ethyl]quinolin-2-yl}piperazine-1-carboxylate 1306784-64-4 C25H26FN7O2 475.526 —— (4-{7-fluoro-8-methyl-3-[(1S)-1-(pyrido[3,4-d]pyrimidin-4-ylamino)ethyl]quinolin-2-yl}piperazin-1-yl)acetic acid 1306784-90-6 C25H26FN7O2 475.526 —— 1-{7-fluoro-8-methyl-3-[(1S)-1-(pyrido[3,2-d]pyrimidin-4-ylamino)ethyl]quinolin-2-yl}piperidine-4-carboxylic acid 1306784-82-6 C25H25FN6O2 460.511 —— 1-{7-fluoro-8-methyl-3-[(1S)-1-(pyrido[3,4-d]pyrimidin-4-ylamino)ethyl]quinolin-2-yl}piperidine-4-carboxamide 1306784-89-3 C25H26FN7O 459.526 —— 2-({7-fluoro-8-methyl-3-[(1S)-1-(9H-purin-6-ylamino)ethyl]quinolin-2-yl}sulfanyl)-ethanol 1307298-84-5 C19H19FN6OS 398.464 —— 1-{7-fluoro-8-methyl-3-[(1S)-1-(pyrido[3,4-d]pyrimidin-4-ylamino)ethyl]quinolin-2-yl}-N-methylpiperidine-4-carboxamide 1306784-87-1 C26H28FN7O 473.553 —— (4-{7-fluoro-8-methyl-3-[(1S)-1-(pyrido[3,2-d]pyrimidin-4-ylamino)ethyl]quinolin-2-yl}piperazin-1-yl)acetic acid 1306784-77-9 C25H26FN7O2 475.526 - 1