1-(all-trans-retinoyloxy)-2-propanone

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 1-(all-trans-retinoyloxy)-2-propanone
• 英文别名: 1-(9-cis-retinoyloxy)-2-propanone；2-oxopropyl (2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoate
• 化学式: C₂₃H₃₂O₃
• 分子量: 356.505
• InChiKey: WYLFKKHGPWTZRY-COYQMWIBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  维A酸 、 一氯丙酮 在 氢氧化钾 作用下， 以 甲醇 、 正己烷 、 正庚烷 、 二氯甲烷 、 水 、 乙腈 为溶剂， 生成 1-(all-trans-retinoyloxy)-2-propanone
  参考文献：
  名称：

  Topical transretinoids for treatment of acne and skin diseases

  摘要：

  13-反式视黄醇酸的酯和酰胺被披露，用于治疗痤疮和皮肤疾病。

  公开号：

  US04885311A1

文献信息

• Topical transretinoids for treatment of acne and skin diseases
  申请人：Molecular Design International

  公开号：US04885311A1

  公开（公告）日：1989-12-05

  Esters and amides of 13-trans-retinoic acid are disclosed which are used for the treatment of acne and skin diseases.

  13-反式视黄醇酸的酯和酰胺被披露，用于治疗痤疮和皮肤疾病。
• Topical compositions for treatment of skin conditions
  申请人：Purcell William Paul

  公开号：US20080139518A1

  公开（公告）日：2008-06-12

  The invention provides a topical formulation adapted for treatment of a skin condition comprising (i) at least one retinoid; and (ii) salicylic acid or an ester, amide, salt, or solvate thereof. The invention also includes a kit for treatment of skin conditions comprising a retinoid and salicylic acid, as well as a method of treating skin conditions utilizing the inventive formulation and kit.
• TOPICAL COMPOSITIONS FOR TREATMENT OF SKIN CONDITIONS
  申请人：CONCERT, LLC

  公开号：US20130237505A1

  公开（公告）日：2013-09-12

  The invention provides a topical formulation adapted for treatment of a skin condition comprising (i) at least one retinoid; and (ii) salicylic acid or an ester, amide, salt, or solvate thereof. The invention also includes a kit for treatment of skin conditions comprising a retinoid and salicylic acid, as well as a method of treating skin conditions utilizing the inventive formulation and kit.
• US5837728A
  申请人：——

  公开号：US5837728A

  公开（公告）日：1998-11-17
• US8865694B2
  申请人：——

  公开号：US8865694B2

  公开（公告）日：2014-10-21