ethyl-1,4-dihydro-4-oxoquinoline-3-carbohydrazide | 1403889-01-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: ethyl-1,4-dihydro-4-oxoquinoline-3-carbohydrazide
• 英文别名: 1 -ethyl-4-oxoquinoline-3-carbohydrazide；1-Ethyl-4-oxoquinoline-3-carbohydrazide；1-ethyl-4-oxoquinoline-3-carbohydrazide
• CAS: 1403889-01-9
• 化学式: C₁₂H₁₃N₃O₂
• 分子量: 231.254
• InChiKey: ADDJFWHNHDPMFH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  75.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl-1,4-dihydro-4-oxoquinoline-3-carbohydrazide 、 2-甲酰基苯硼酸 在 ammonium hydroxide 作用下， 以 乙醇 为溶剂， 反应 0.5h， 以59.23%的产率得到1-ethyl-3-(1-hydroxy-2,3,1-benzodiazaborinine-2-carbonyl)quinolin-4-one
  参考文献：
  名称：

  [EN] BORON CONTAINING COMPOUNDS AND THEIR USES
  [FR] COMPOSÉS CONTENANT DU BORE ET LEURS UTILISATIONS

  摘要：

  本公开涉及一种含硼化合物，其中包含该化合物的杀虫有效量溶解或分散在载体介质中的组合物，以及通过向需要的植物或动物施用所述组合物来减少、改善或控制害虫，特别是真菌侵害的方法。

  公开号：

  WO2020264581A1
• 作为产物：
  描述：

  2-苯基氨基亚甲基-丙二酸二乙酯 在 potassium carbonate 、 一水合肼 作用下， 以 二苯醚 、 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 20.0h， 生成 ethyl-1,4-dihydro-4-oxoquinoline-3-carbohydrazide
  参考文献：
  名称：

  Synthesis and study of 1-ethyl-3-carbohydrazide and 3-[1-oxo-2-hydrazino-3-{p-toluenesulfon}]quinolone derivatives against bacterial infections

  摘要：

  We have synthesized newer series of quinolone derivatives substituted with hydrazine group (6a-e) and sulfonamide group (7a-e). These compounds were screened for antibacterial activity. All these compounds were fully characterized by spectroscopic means and elemental analysis. From minimum inhibitory concentration (MIC) data, it has been observed that all the synthesized compounds exhibited good antibacterial activity in vitro. (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.06.056

文献信息

• [EN] BORON CONTAINING COMPOUNDS AND THEIR USES<br/>[FR] COMPOSÉS CONTENANT DU BORE ET LEURS UTILISATIONS
  申请人：BORAGEN INC

  公开号：WO2020264581A1

  公开（公告）日：2020-12-30

  The present disclosure contemplates a boron-containing compound, a composition containing a pesticidal effective amount of that compound dissolved or dispersed in a carrier medium, and a method of reducing, ameliorating, or controlling an infestation by a pest, particularly a fungus, by administering a contemplated composition to a plant or animal in need.

  本公开涉及一种含硼化合物，其中包含该化合物的杀虫有效量溶解或分散在载体介质中的组合物，以及通过向需要的植物或动物施用所述组合物来减少、改善或控制害虫，特别是真菌侵害的方法。
• Synthesis and study of 1-ethyl-3-carbohydrazide and 3-[1-oxo-2-hydrazino-3-{p-toluenesulfon}]quinolone derivatives against bacterial infections
  作者：Nivedita Srivastava、Anil Kumar

  DOI：10.1016/j.ejmech.2013.06.056

  日期：2013.9

  We have synthesized newer series of quinolone derivatives substituted with hydrazine group (6a-e) and sulfonamide group (7a-e). These compounds were screened for antibacterial activity. All these compounds were fully characterized by spectroscopic means and elemental analysis. From minimum inhibitory concentration (MIC) data, it has been observed that all the synthesized compounds exhibited good antibacterial activity in vitro. (C) 2013 Elsevier Masson SAS. All rights reserved.