4-geranoyl-3,5-dimethoxybenzaldehyde | 439944-36-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 4-geranoyl-3,5-dimethoxybenzaldehyde
• 英文别名: 4-[(2E)-3,7-dimethylocta-2,6-dienoxy]-3,5-dimethoxybenzaldehyde
• CAS: 439944-36-2
• 化学式: C₁₉H₂₆O₄
• 分子量: 318.413
• InChiKey: IMQJIJZYIWAIJH-OQLLNIDSSA-N

物化性质

• 沸点：
  456.8±45.0 °C(Predicted)
• 密度：
  1.032±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  23
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-geranoyl-3,5-dimethoxybenzaldehyde 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 24.0h， 生成 4-O-geranylsinapic alcohol
  参考文献：
  名称：

  Design, synthesis, and SAR analysis of cytotoxic sinapyl alcohol derivatives

  摘要：

  Five series totalling 51 of sinapyl alcohol derivatives were designed and synthesized. Their cytotoxicity analyses were performed oil six human tumor cell lines Such as PC-3. CNE, KB, A549, BEL-7404, and HeLa. Certain sinapyl alcohol derivatives showed significant cytotoxic activities. Compound 14d exhibited especially potent cytotoxicity against the BEL-7404 cell line with an IC50 value of 0.7 mu M, which showed more cytotoxic activity than the positive control, cisplatin. The structure-cytotoxicity relationships were discussed and the CoMFA analysis was performed using the cytotoxic data against HeLa cells as a template. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2005.10.056
• 作为产物：
  描述：

  4-geranoyl-3,5-dimethoxybenzyl alcohol 在 pyridinium chlorochromate 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 以86%的产率得到4-geranoyl-3,5-dimethoxybenzaldehyde
  参考文献：
  名称：

  两种细胞毒性芥子醇衍生物的合成以及四种来自Li草的相关化合物的分离。

  摘要：

  通过对叶Li草进行植物化学再研究，得到了四种新的芥子醇类似物，命名为nelumols BE（1-4）和三种已知的芥子醇衍生物（5-7）。通过NMR技术阐明了它们的结构。通过两种不同的途径进行了细胞毒性的香叶基香叶醇（6）和香叶基香叶醛（7）的合成。还合成了4-O-苄基取代的类似物（20和27）以及4-O-（2-甲基丁烯基）衍生物（34和35）。使用A-549，HL-60和KB癌细胞系测量了6和7的细胞毒性。

  DOI：

  10.1021/np0200257

文献信息

• Synthesis of O-prenylated and O-geranylated derivatives of 5-benzylidene2,4-thiazolidinediones and evaluation of their free radical scavenging activity as well as effect on some phase II antioxidant/detoxifying enzymes
  作者：Sk. Ugir Hossain、Sudin Bhattacharya

  DOI：10.1016/j.bmcl.2006.12.040

  日期：2007.3

  A series of 5-arylidene-2,4-thiazolidinediones and its geranyloxy or prenyloxy derivative were synthesized and studied for their radical scavenging activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. Their comparable scavenging activities were expressed as IC50 value. Compounds 2c, 2d, 4d, and 6a showed appreciable radical scavenging activities. The vanillin based thiazolidinedione compound 2c displayed highest activity comparable to that of alpha-tocopherol. But in vivo, compound 6a showed better results in inducing phase II detoxifying/antioxidative enzyme.
• Design, synthesis, and SAR analysis of cytotoxic sinapyl alcohol derivatives
  作者：Hong Bin Zou、Sheng Yi Dong、Chang Xin Zhou、Li Hong Hu、Yi Hang Wu、Hai Bo Li、Jing Xu Gong、Lian Li Sun、Xiu Mei Wu、Hua Bai、Bo Tao Fan、Xiao Jiang Hao、Joachim Stöckigt、Yu Zhao

  DOI：10.1016/j.bmc.2005.10.056

  日期：2006.3

  Five series totalling 51 of sinapyl alcohol derivatives were designed and synthesized. Their cytotoxicity analyses were performed oil six human tumor cell lines Such as PC-3. CNE, KB, A549, BEL-7404, and HeLa. Certain sinapyl alcohol derivatives showed significant cytotoxic activities. Compound 14d exhibited especially potent cytotoxicity against the BEL-7404 cell line with an IC50 value of 0.7 mu M, which showed more cytotoxic activity than the positive control, cisplatin. The structure-cytotoxicity relationships were discussed and the CoMFA analysis was performed using the cytotoxic data against HeLa cells as a template. (c) 2005 Elsevier Ltd. All rights reserved.
• Syntheses of Two Cytotoxic Sinapyl Alcohol Derivatives and Isolation of Four New Related Compounds from <i>Ligularia</i> <i>n</i><i>elumbifolia</i>
  作者：Yu Zhao、Xiaojiang Hao、Wei Lu、Junchao Cai、Hong Yu、Thierry Sevénet、Françoise Guéritte

  DOI：10.1021/np0200257

  日期：2002.6.1

  Phytochemical reinvestigation on Ligularia nelumbifolia afforded four novel sinapyl alcohol analogues named nelumols B-E (1-4) and three known sinapyl alcohol derivatives (5-7). Their structures were elucidated by NMR techniques. Total syntheses of cytotoxic geranyloxy sinapyl alcohol (6) and geranyloxy sinapyl aldehyde (7) were carried out via two different paths. The 4-O-benzyl-substituted analogues

  通过对叶Li草进行植物化学再研究，得到了四种新的芥子醇类似物，命名为nelumols BE（1-4）和三种已知的芥子醇衍生物（5-7）。通过NMR技术阐明了它们的结构。通过两种不同的途径进行了细胞毒性的香叶基香叶醇（6）和香叶基香叶醛（7）的合成。还合成了4-O-苄基取代的类似物（20和27）以及4-O-（2-甲基丁烯基）衍生物（34和35）。使用A-549，HL-60和KB癌细胞系测量了6和7的细胞毒性。