喹啉-2-基甲基乙酸酯 | 60483-07-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 喹啉-2-基甲基乙酸酯
• 英文名称: 2-(acetoxymethyl)-quinoline
• 英文别名: acetic acid quinolin-2-ylmethyl ether；2‐quinolylmethyl acetate；acetic acid-[2]quinolylmethyl ester；Essigsaeure-[2]chinolylmethylester；methylcarbonyloxymethylquinoline；Quinolin-2-ylmethyl acetate
• CAS: 60483-07-0
• 化学式: C₁₂H₁₁NO₂
• mdl: MFCD09373423
• 分子量: 201.225
• InChiKey: DNRJGKANFCXPLY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2933499090

反应信息

• 作为反应物：
  描述：

  喹啉-2-基甲基乙酸酯 在 盐酸 、 水 作用下， 生成 phenyl-carbamic acid-[2]quinolylmethyl ester
  参考文献：
  名称：

  Rearrangements of N-Oxides. A Novel Synthesis of Pyridyl Carbinols and Aldehydes

  摘要：

  DOI：

  10.1021/ja01634a026
• 作为产物：
  描述：

  喹哪啶酸 在 吡啶 、 4-二甲氨基吡啶 、 sodium tetrahydroborate 、 硫酸 、 lithium chloride 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 51.0h， 生成 喹啉-2-基甲基乙酸酯
  参考文献：
  名称：

  Samarium-Promoted Coupling of Pyridine-Based Heteroaryl Analogues of Benzylic Acetates with Carbonyl Compounds

  摘要：

  [GRAPHICS]2-Substituted pyridine, quinoline, isoquinoline, bipyridine, and 1,10-phenanthroline analogues of benzylic acetates undergo Sml(2)-promoted coupling with aldehydes and ketones to afford (2-hydroxyalkyl)heteroaromatics.

  DOI：

  10.1021/ol050944z

文献信息

• Highly Enantioselective Iridium-Catalyzed Hydrogenation of Heteroaromatic Compounds, Quinolines
  作者：Wen-Bo Wang、Sheng-Mei Lu、Peng-Yu Yang、Xiu-Wen Han、Yong-Gui Zhou

  DOI：10.1021/ja0353762

  日期：2003.9.1

  The highly enantioselective hydrogenation of quinoline derivatives is developed using [Ir(COD)Cl]2/(R)-MeO-Biphep/I2 system, and this methodology has been applied to the asymmetric synthesis of three naturally occurring alkaloids angustureine, galipinine, and cuspareine. This method provided an efficient access to a variety of optically active tetrahydroquinolines with up to 96% ee.

  喹啉衍生物的高度对映选择性氢化是使用 [Ir(COD)Cl]2/(R)-MeO-Biphep/I2 系统开发的，该方法已应用于三种天然生物碱 angustureine、galipinine 和葛根素。这种方法可以有效地获得各种具有高达 96% ee 的光学活性四氢喹啉。
• [EN] MULTIPHOTON ACTIVABLE QUINOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USES<br/>[FR] DÉRIVÉS DE QUINOLINE À ACTIVATION MULTIPHOTONIQUE, PRÉPARATION ET UTILISATIONS ASSOCIÉES
  申请人：CENTRE NAT RECH SCIENT

  公开号：WO2011086469A1

  公开（公告）日：2011-07-21

  The present invention relates to multiphoton activable organic compounds responding to the following formula (I). The present invention also relates to a method of synthesizing the compounds of the invention, to an aqueous solution comprising at least one compound of the invention, and to their specific uses. The present invention also concerns a method of liberating organic ligands, said method involving the step of irradiating a compound according to the invention.

  本发明涉及对以下公式（I）响应的多光子可激活有机化合物。本发明还涉及一种合成本发明化合物的方法，一种包含至少一种本发明化合物的水溶液，以及它们的特定用途。本发明还涉及一种释放有机配体的方法，该方法涉及辐照根据本发明的化合物的步骤。
• Method of making and administering quinoline derivatives as anti-cancer agents
  申请人：Chan Albert Sun-chi

  公开号：US09321730B2

  公开（公告）日：2016-04-26

  The present invention relates methods of preparing quinoline derivative compounds, and administering such compounds in the treatment of solid and non-solid tumors, notably on liver cancer.

  本发明涉及制备喹啉衍生物化合物的方法，并在固体和非固体肿瘤的治疗中施用此类化合物，特别是在肝癌治疗中。
• Multiphoton Activable Quinoline Derivatives, Their Preparation and Their Uses
  申请人：Dalko Peter

  公开号：US20130116281A1

  公开（公告）日：2013-05-09

  The present invention relates to multiphoton activable organic compounds responding to the following formula (I). The present invention also relates to a method of synthesizing the compounds of the invention, to an aqueous solution comprising at least one compound of the invention, and to their specific uses. The present invention also concerns a method of liberating organic ligands, said method involving the step of irradiating a compound according to the invention.

  本发明涉及响应以下式（I）的多光子可激活有机化合物。本发明还涉及一种合成本发明化合物的方法，涉及至少包含一种本发明化合物的水溶液，以及它们的特定用途。本发明还涉及一种释放有机配体的方法，该方法涉及照射本发明化合物的步骤。
• Visible-Light-Induced Synthesis of Branched Ethers via Multicomponent Reactions
  作者：Nándor Győrfi、Gábor Tasnádi、Márió Gyuris、Andras Kotschy

  DOI：10.1021/acs.joc.3c00804

  日期：2023.7.21

  derivatives as radical trapping agents, and alcohols as nucleophilic quenchers. The novel radical-polar crossover reaction provides access to a diverse set of branched ethers possessing high structural complexity. The utility of the transformation was also demonstrated by the synthesis of a complex drug derivative and it was easily scalable to the multigram level. The scope and limitations were also explored

  自旋中心转移（SCS）消除是产生与合成和生化途径相关的自由基的特定方式。SCS介导的自由基化学和原子转移自由基加成（ATRA）的结合为面向多样性的化学合成提供了新的方向。在此，我们报道了α-酰氧基-N-杂环作为自由基前体、苯乙烯衍生物作为自由基捕获剂和醇作为亲核猝灭剂的光氧化还原三组分反应。新颖的自由基-极性交叉反应提供了获得具有高结构复杂性的多种支链醚的途径。复杂药物衍生物的合成也证明了这种转化的实用性，并且它很容易扩展到多克水平。还探讨了范围和局限性，并提出了一个合理的机制。