2-(4-氯苯氧基)-5-硝基吡啶 | 28232-30-6

• 物质功能分类: 医药中间体 - 杂环化合物 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-(4-氯苯氧基)-5-硝基吡啶
• 英文名称: 2-(4'-chlorophenoxy)-5-nitropyridine
• 英文别名: 2-(4-chlorophenoxy)-5-nitropyridine；5-nitro-2-(4-chlorophenoxy)pyridine；6-(4-chlorophenoxy)-3-nitropyridine；2-(4-chloro-phenoxy)-5-nitro-pyridine；2-(4-Chlor-phenoxy)-5-nitro-pyridin
• CAS: 28232-30-6
• 化学式: C₁₁H₇ClN₂O₃
• 分子量: 250.641
• InChiKey: ZQVHTTABFLHMPA-UHFFFAOYSA-N

物化性质

• 熔点：
  93 °C

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  67.9
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 危险品标志：
  T
• 安全说明：
  S24/25,S36/37,S45
• 危险类别码：
  R25,R43
• 海关编码：
  2933399090

SDS

Name:	2-(4-Chlorophenoxy)-5-nitropyridine 97% Material Safety Data Sheet
Synonym:
CAS:	28232-30-6

Section 1 - Chemical Product MSDS Name:2-(4-Chlorophenoxy)-5-nitropyridine 97% Material Safety Data Sheet
Synonym:

---

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
28232-30-6	2-(4-Chlorophenoxy)-5-nitropyridine	97%	unlisted

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

---

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Not available.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. May be harmful if absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation:
May cause respiratory tract irritation. May be harmful if inhaled.
Chronic:
Not available.

---

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately.
Notes to Physician:
Treat symptomatically and supportively.

---

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

---

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

---

Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

---

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 28232-30-6: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

---

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: Not available.
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 93 - 96 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C11H7ClN2O3
Molecular Weight: 250.64

---

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Hydrogen chloride, chlorine, nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported

---

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 28232-30-6 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
2-(4-Chlorophenoxy)-5-nitropyridine - Not listed by ACGIH, IARC, or NTP.

---

Section 12 - ECOLOGICAL INFORMATION

---

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

---

Section 14 - TRANSPORT INFORMATION

IATA
No information available.
IMO
No information available.
RID/ADR
No information available.

---

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 28232-30-6: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 28232-30-6 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 28232-30-6 is not listed on the TSCA inventory.
It is for research and development use only.

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  2-(4-氯苯氧基)-5-硝基吡啶 在 盐酸 、 铁粉 、 对甲苯磺酸 作用下， 以 5,5-dimethyl-1,3-cyclohexadiene 、 乙醇 、 水 为溶剂， 反应 16.5h， 生成
  参考文献：
  名称：

  JP5748641

  摘要：

  公开号：
• 作为产物：
  描述：

  2-氯-5-硝基吡啶 、 对氯苯酚 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 以94%的产率得到2-(4-氯苯氧基)-5-硝基吡啶
  参考文献：
  名称：

  一种异噻唑类化合物及其用途

  摘要：

  本发明属于农用杀菌、杀螨剂领域。具体地涉及一种异噻唑类化合物及其用途。化合物结构如下通式所示：式中各取代基的定义见说明书。通式化合物在农业领域中具有广谱的杀菌、杀虫活性，对玉米锈病、水稻稻瘟病、黄瓜霜霉病、黄瓜炭疽病等多种病菌都有很好的防效。特别地，对黄瓜霜霉病、黄瓜炭疽病在较低剂量下仍具有很好的防治效果。同时，本发明的部分化合物还具有较好的杀螨活性，可用于防治朱砂叶螨等。

  公开号：

  CN106543167B

文献信息

• Urea derivatives, and their production and use
  申请人：Sumitomo Chemical Company, Limited

  公开号：US04334912A1

  公开（公告）日：1982-06-15

  A compound of the formula: ##STR1## wherein A is a hydrogen atom, a methyl group or a methoxy group, X is a straight or branched C.sub.1 -C.sub.4 alkylene chain, Y is an oxygen atom or a sulfur atom, R, which may be the same or different, is a lower alkyl group, a lower alkoxy group, a trifluoromethyl group, a chlorine atom, a bromine atom or a fluorine atom, m is an integer of 0 to 5 and n is an integer of 0 or 1, provided that in case of R being a fluorine atom, m is an integer of 0 to 5 and in case of R being other than a fluorine atom, m is an integer of 0 to 3, which shows a pronounced herbicidal activity against a wide variety of weeds in the cultivation of crop plants without any material toxicity to mammals and any chemical injury to said crop plants.

  化合物的式子为：##STR1## 其中 A 是氢原子、甲基基团或甲氧基团，X 是直链或支链的 C.sub.1-C.sub.4 烷基链，Y 是氧原子或硫原子，R 可以是相同或不同的低烷基、低烷氧基、三氟甲基、氯原子、溴原子或氟原子，m 是 0 到 5 的整数，n 是 0 或 1 的整数，但当 R 是氟原子时，m 是 0 到 5 的整数，当 R 不是氟原子时，m 是 0 到 3 的整数。该化合物在作物种植中对各种杂草表现出显著的除草活性，对哺乳动物没有任何毒性，对作物也没有任何化学伤害。
• Shibasaki, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1951, vol. 71, p. 786
  作者：Shibasaki

  DOI：——

  日期：——
• Convenient Synthesis of Heteroaryl Phenyl Ethers from Chloropyridines and Chloroquinolines using Phase-Transfer Catalysis
  作者：Hattab Alsaidi、Roger Gallo、Jacques Metzger

  DOI：10.1055/s-1980-29272

  日期：——
• Kinetics of the reaction of 2-chloro-3-nitro- and 2-chloro-5-nitropyridines with aryloxide ions in methanol
  作者：Ali A. El-Bardan

  DOI：10.1002/(sici)1099-1395(199904)12:4<347::aid-poc134>3.0.co;2-g

  日期：1999.4

  The kinetics of the reaction of 2-chloro-3-nitropyridine (ortho-like) and 2-chloro-5-nitropyridine (para-like) with a series of aryloxide ions were studied in methanol at different temperatures. Plots of Delta H-not equal versus Delta S-not equal for both reactions gave good straight lines with isokinetic temperatures of 168 and 195 degrees C. Good linear relationships were obtained from the plots of log k(2) against sigma degrees values with relatively large negative rho values indicating the formation of Meisenheimer sigma-complex intermediates. Plots of log k(2) against pK(a) values gave good straight lines indicating that the reactions show an appreciable degree of bond formation in the transition state. An addition-elimination mechanism is suggested. Copyright (C) 1999 John Wiley & Sons, Ltd.
• Makosza; Ludwiczak, Polish Journal of Chemistry, 1998, vol. 72, # 7, p. 1168 - 1172
  作者：Makosza、Ludwiczak

  DOI：——

  日期：——