α-D-Glcp-(1->6)-α-D-Glcp-(1->6)-α-D-Glcp-(1->6)-D-Glcp | 15785-89-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: α-D-Glcp-(1->6)-α-D-Glcp-(1->6)-α-D-Glcp-(1->6)-D-Glcp
• 英文别名: Glc1->6Glc1->6Glc1->6Glc；isomaltotetraose；Glc(a1-6)Glc(a1-6)Glc(a1-6)Glc；(3R,4S,5S,6R)-6-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxymethyl]oxan-2-yl]oxymethyl]oxane-2,3,4,5-tetrol
• CAS: 15785-89-4
• 化学式: C₂₄H₄₂O₂₁
• 分子量: 666.585
• InChiKey: DFKPJBWUFOESDV-KGUZVYKUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -9
• 重原子数：
  45
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  348
• 氢给体数：
  14
• 氢受体数：
  21

反应信息

• 作为反应物：
  描述：

  isomaltotriose 、 α-D-Glcp-(1->6)-α-D-Glcp-(1->6)-α-D-Glcp-(1->6)-D-Glcp 以obtained similarly as in EXAMPLE 3的产率得到葡萄糖
  参考文献：
  名称：

  Imparting low- or anti-cariogenic property to orally-usable products

  摘要：

  本发明揭示了一种提供具有低或抗龋齿特性的口服产品生产工艺。该工艺包括使用或添加具有显著抗龋齿性的糖类来制备这些产品。本发明中优选的糖类包括异麦芽糖单糖，二糖，三糖和其还原产物；例如，泊诺糖，异麦芽三糖，异麦芽糖麦芽糖，异麦芽四糖，异麦芽五糖和其还原产物，即泊诺醇，异麦芽三醇，异麦芽糖麦芽醇，异麦芽四醇和异麦芽五醇。这些糖类可用于生产任何口服产品，包括一般的食品和饮料，以赋予它们显著的低或抗龋齿特性，同时也可以用来增甜。

  公开号：

  US04518581A1
• 作为产物：
  描述：

  左旋多巴 、 蔗糖 在 glucansucrases from Leuconostoc mesenteroides 作用下， 以 pyridinium acetate buffer 为溶剂， 反应 24.0h， 生成 果糖 、 D-isomaltose 、 Isomaltulose 、 α-D-Glcp-(1->6)-α-D-Glcp-(1->6)-α-D-Glcp-(1->6)-D-Glcp 、 leucrose 、 isomaltotriose 、 葡萄糖 、 4-O-α-D-glucopyranosyl L-DOPA 、 3-O-α-D-glucopyranosyl L-DOPA
  参考文献：
  名称：

  通过与四个中肠十二指肠球菌菌株的四种不同葡聚糖蔗糖催化的蔗糖反应，酶促合成L-DOPAα-糖苷。

  摘要：

  L-DOPAα-糖苷是通过L-DOPA与蔗糖的反应合成的，该酶由四种不同的葡聚糖酶催化，这些葡聚糖分别来自间叶亮毛球菌B-512FMC，B-742CB，B-1299A和B-1355C。葡聚糖蔗糖催化d-葡萄糖从蔗糖转移到L-DOPA的酚羟基位置-3和-4。通过Bio-Gel P-2柱色谱法分离和纯化糖苷，并通过（1）H NMR光谱确定结构。主要糖苷是4-O-α-d-吡喃葡萄糖基L-DOPA，次要糖苷是3-O-α-D-吡喃葡萄糖基L-DOPA。这两个糖苷是由所有四个葡聚糖酶形成的。由B-512FMC葡聚糖转移酶产生的4-O-α-糖苷与3-O-α-糖苷的比例高于其他三种葡聚糖。L-DOPA的糖基化作用显着降低了酚羟基的氧化，从而阻止了其甲基化，从而潜在地增加了L-DOPA在帕金森氏病治疗中的应用。与先前公开的使用环麦芽糊精和环麦芽糊精葡糖基转移酶，随后进行葡糖淀粉酶和β-淀粉酶水解的方法相比，

  DOI：

  10.1016/j.carres.2010.05.001

文献信息

• Acetolysis of Leuconostoc mesenteroides NRRL B-1299 dextran. Isolation and characterization of oligosaccharides containing secondary linkages from the borate-soluble fraction
  作者：Toshiyuki Watanabe、Michiko Chiba、Yutaka Matsuda、Fukuko Sakurai、Mikihiko Kobayashi、Kazuo Matsuda

  DOI：10.1016/s0008-6215(00)85371-9

  日期：1980.8

  Fractionation of the deacetylated acetolyzate of the borate-soluble fraction of the dextran elaborated by L. mesenteroides NRRL B-1299 gave, after chromatography on charcoal-Celite, preparative paper-chromatography, and paper electrophoresis, 4 trisaccharide fractions and 4-tetrasaccharide fractions. The isolated oligosaccharides were characterized by their paper-chromatographic mobility, examination of partial acid-hydrolyzates of the oligosaccharides and their corresponding alditols, and methylation analysis. These oligosaccharides were kojitriose, isomaltotriose, a mixture of 2-O-.alpha.-isomaltosyl-D-glucose, 21-O-.alpha.-D-glucosylisomaltose and 2-O-.alpha.-nigerosyl-D-glucose, 6-O-.alpha.-kojibiosyl-D-glucose, isomaltotetraose, a mixture of 2-O-.alpha.-isomaltotriosyl-D-glucose and 21-O-.alpha.-D-glucosylisomaltotriose, 6-O-.alpha.-kojitriosyl-D-glucose and 63-O-.alpha.-D-glucosylkojitriose, respectively. Some of these oligosaccharides are newly isolated and characterized.
• Enzymatic synthesis of l-DOPA α-glycosides by reaction with sucrose catalyzed by four different glucansucrases from four strains of Leuconostoc mesenteroides
  作者：Seung-Heon Yoon、D. Bruce Fulton、John F. Robyt

  DOI：10.1016/j.carres.2010.05.001

  日期：2010.8

  d-glucose from sucrose to the phenolic hydroxyl position-3 and -4 of L-DOPA. The glycosides were fractionated and purified by Bio-Gel P-2 column chromatography, and the structures were determined by (1)H NMR spectroscopy. The major glycoside was 4-O-alpha-d-glucopyranosyl L-DOPA, and the minor glycoside was 3-O-alpha-D-glucopyranosyl L-DOPA. The two glycosides were formed by all four of the glucansucrases

  L-DOPAα-糖苷是通过L-DOPA与蔗糖的反应合成的，该酶由四种不同的葡聚糖酶催化，这些葡聚糖分别来自间叶亮毛球菌B-512FMC，B-742CB，B-1299A和B-1355C。葡聚糖蔗糖催化d-葡萄糖从蔗糖转移到L-DOPA的酚羟基位置-3和-4。通过Bio-Gel P-2柱色谱法分离和纯化糖苷，并通过（1）H NMR光谱确定结构。主要糖苷是4-O-α-d-吡喃葡萄糖基L-DOPA，次要糖苷是3-O-α-D-吡喃葡萄糖基L-DOPA。这两个糖苷是由所有四个葡聚糖酶形成的。由B-512FMC葡聚糖转移酶产生的4-O-α-糖苷与3-O-α-糖苷的比例高于其他三种葡聚糖。L-DOPA的糖基化作用显着降低了酚羟基的氧化，从而阻止了其甲基化，从而潜在地增加了L-DOPA在帕金森氏病治疗中的应用。与先前公开的使用环麦芽糊精和环麦芽糊精葡糖基转移酶，随后进行葡糖淀粉酶和β-淀粉酶水解的方法相比，
• Imparting low- or anti-cariogenic property to orally-usable products
  申请人：Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo

  公开号：US04518581A1

  公开（公告）日：1985-05-21

  An invention providing a process for producing orally-usable products possessing low- or anti-cariogenic properties is disclosed. The process comprises preparing said products with, or adding thereto a saccharide having a substantial anti-cariogenicity. The saccharides preferred in the invention are isomaltosyl mono-, di-, tri-glucoses, and reduction products thereof; for example, panose, isomaltotriose, isomaltosyl maltose, isomaltotetraose, isomaltopentaose, and reduction products thereof, i.e., pannitol, isomaltotriitol, isomaltosyl maltitol, isomaltotetraitol, and isomaltopentaitol. Such saccharides can be used in the production of any products used orally, including foods and drinks in general, to impart thereto a substantial low- or anti-cariogenic property, as well as to sweeten them.

  本发明揭示了一种提供具有低或抗龋齿特性的口服产品生产工艺。该工艺包括使用或添加具有显著抗龋齿性的糖类来制备这些产品。本发明中优选的糖类包括异麦芽糖单糖，二糖，三糖和其还原产物；例如，泊诺糖，异麦芽三糖，异麦芽糖麦芽糖，异麦芽四糖，异麦芽五糖和其还原产物，即泊诺醇，异麦芽三醇，异麦芽糖麦芽醇，异麦芽四醇和异麦芽五醇。这些糖类可用于生产任何口服产品，包括一般的食品和饮料，以赋予它们显著的低或抗龋齿特性，同时也可以用来增甜。