l-Menthyl 3,4,6-tri-O-benzyl-β-D-glucopyranoside | 121654-12-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: l-Menthyl 3,4,6-tri-O-benzyl-β-D-glucopyranoside
• 英文别名: (1R,2S,5R)-menthyl 3,4,6-tri-O-benzyl-β-D-glucopyranoside；(2R,3R,4R,5R,6R)-2-[(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl]oxy-4,5-bis(phenylmethoxy)-6-(phenylmethoxymethyl)oxan-3-ol
• CAS: 121654-12-4
• 化学式: C₃₇H₄₈O₆
• 分子量: 588.785
• InChiKey: SDOKOQNRRQRYSZ-GSOXVRFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  43
• 可旋转键数：
  13
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.51
• 拓扑面积：
  66.4
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  l-Menthyl 3,4,6-tri-O-benzyl-β-D-glucopyranoside 以88%的产率得到
  参考文献：
  名称：

  HALCOMB, RANDALL L.;DANISHEFSKY, SAMUEL J., J. AMER. CHEM. SOC., 111,(1989) N7, C. 6661-6666

  摘要：

  DOI：
• 作为产物：
  描述：

  3,4,6-三苄氧基-D-葡萄烯糖 在 二甲基二环氧乙烷 、 zinc(II) chloride 作用下， 以 四氢呋喃 、 二氯甲烷 、 丙酮 为溶剂， 反应 14.0h， 生成 l-Menthyl 3,4,6-tri-O-benzyl-β-D-glucopyranoside
  参考文献：
  名称：

  关于糖基的直接环氧化：应用迭代策略合成 β-连接的寡糖

  摘要：

  合成这些低聚糖 a partir du tri-O-acetyl-3,4,6 glucal et du dimethyl-3,3 dioxiranne

  DOI：

  10.1021/ja00199a028

文献信息

• Experimental evidence on the hydroxymethyl group conformation in alkyl β-d-mannopyranosides
  作者：Carlos Mayato、Rosa Dorta、Jesús Vázquez

  DOI：10.1016/j.tetasy.2004.06.019

  日期：2004.8

  A rotational population Study of the hydroxymethyl group of alkyl beta-D-mannopyranosides was performed by means of CD and NMR spectroscopy. Three different benzyl, acetyl, and p-bromobenzoyl series of alkyl beta-D-mannopyranosides with different chiral and nonchiral aglycons were synthesized and analyzed. Different rotational populations were observed for each series by changing the structure of the aglycon. The results showed a clear correlation between the rotational population of the hydroxymethyl group around the C5-C6 bond and the pK(a) of the bonded alcohol (aglycon). The population of the gt rotamer gradually increased as the pK(a) increased while that of the gg rotamer decreased and the population of the tg rotamer remained almost constant. This is explained by the exo-anomeric effect. For chiral alkyl derivatives, the results also showed a close dependence on the absolute configuration of the aglycon. Comparison of rotational population anomers revealed the dependence or the hydroxymethyl group on the anomeric configuration and a greater dependence on the aglycon structure in the beta anomers. (C) 2004 Elsevier Ltd. All rights reserved.