The present invention is directed in particular to dipeptide-like compounds derived from functionally substituted amino acids, having fatty acid chains bound thereto through amidification of the amine functional groups of said dipeptide-like compounds, one end portion of which bears an accessory functional side chain spacer, with the other end portion being an acid group either in neutral or charged state. Compounds of the present invention have immunomodulating properties like adjuvants, In addition, compounds of the invention can be grafted on a given antigen in order to modulate or tune the immune response or can be equally grafted on a pharmaceutical carrier to enhance the therapeutic effect or targetting thereof. Accordingly, compounds of the invention find use in human and veterinary medicine both as immunogens and diagnostic tools.
本发明特别涉及从功能取代
氨基酸衍生的二肽类化合物,其通过酰胺化二肽类化合物的胺基官能团与
脂肪酸链结合,其中一端部分带有辅助功能侧链间隔物,而另一端部分是中性或带电酸基团。本发明化合物具有像佐剂一样的免疫调节性质。此外,本发明化合物可以嫁接到给定的抗原上,以调节或调整免疫反应,或者可以同样嫁接到药物载体上,以增强治疗效果或定位作用。因此,本发明化合物在人类和兽医学中均可用作免疫原和诊断工具。