左旋-3-溴樟脑-8-磺酸铵盐 | 55870-50-3

• 物质功能分类: 化学试剂 - 有机试剂 - 磺酸盐/亚磺酸盐
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 左旋-3-溴樟脑-8-磺酸铵盐
• 中文别名: 3-溴樟脑磺酸；(-)-3-溴代樟脑-8-磺酸铵盐；(-)-3-溴代莰酮-8-磺酸铵盐；L(-)-Α-溴樟脑-PI-磺酸胺；L(-)-alpha-溴樟脑-pi-磺酸胺
• 英文名称: (1S)-3endo-bromo-2-oxo-bornane-8-sulfonic acid ; ammonium salt
• 英文别名: (1S)-3endo-Brom-2-oxo-bornan-8-sulfonsaeure; Ammonium-Salz；azanium;[(1S,3R,4R)-3-bromo-1,7-dimethyl-2-oxo-7-bicyclo[2.2.1]heptanyl]methanesulfonate
• CAS: 55870-50-3
• 化学式: C₁₀H₁₅BrO₄S*H₃N
• 分子量: 328.227
• InChiKey: GFBVBBRNPGPROZ-FFKCEENZSA-N

物化性质

• 熔点：
  290 °C
• 密度：
  1.4048 (estimate)
• 溶解度：
  可溶于二甲基亚砜、甲醇
• 稳定性/保质期：

  遵照规定使用和储存，则不会分解。

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  80.8
• 氢给体数：
  2
• 氢受体数：
  5

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S36,S37/39
• 危险类别码：
  R36/37/38
• 海关编码：
  2914700090
• 危险性防范说明：
  P261,P280,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H332,H335
• 储存条件：
  请将产品存放在阴凉干燥的环境中。

SDS

Name:	L-(-)-Alpha-Bromocamphor-Pi-Sulfonic Acid Ammonium Salt 99% Material Safety Data Sheet
Synonym:	None Known
CAS:	55870-50-3

Section 1 - Chemical Product MSDS Name:L-(-)-Alpha-Bromocamphor-Pi-Sulfonic Acid Ammonium Salt 99% Material Safety Data Sheet
Synonym:None Known

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
55870-50-3	L-(-)-Alpha-Bromocamphor-Pi-Sulfonic	99%	259-871-2

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 55870-50-3: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Crystalline powder
Color: white
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 280.00 - 285.00 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C10H18BrNO4S
Molecular Weight: 328.21

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, dust generation, excess heat, strong oxidants.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, oxides of sulfur, irritating and toxic fumes and gases, carbon dioxide, hydrogen bromide.
Hazardous Polymerization: Has not been reported.

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 55870-50-3 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
L-(-)-Alpha-Bromocamphor-Pi-Sulfonic Acid Ammonium Salt - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
S 28A After contact with skin, wash immediately with
plenty of water.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 37 Wear suitable gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 55870-50-3: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 55870-50-3 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 55870-50-3 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

化学性质：白色结晶粉末

用途：用于化学中间体的拆分

反应信息

• 作为反应物：
  描述：

  辛弗林 、 左旋-3-溴樟脑-8-磺酸铵盐 在 盐酸 作用下， 以 水 为溶剂， 以60.1%的产率得到(+)-2-methylamino-1-(4-hydroxyphenyl)ethanol (+)-3-bromocamphor-8-sulphonate
  参考文献：
  名称：

  Midgley, John M.; Thonoor, Mohan C.; Drake, Alex F., Journal of the Chemical Society. Perkin transactions II, 1989, p. 963 - 970

  摘要：

  DOI：

文献信息

• PROCESS FOR PREPARING RACEMIC AND ENANTIOMERIC 1-(PYRIDYL)-2-CYCLOHEXYLETHYLAMINE
  申请人：BOEHRINGER INGELHEIM PHARMACEUTICALS INC.

  公开号：EP0821672A2

  公开（公告）日：1998-02-04
• US5616717A
  申请人：——

  公开号：US5616717A

  公开（公告）日：1997-04-01
• [EN] PROCESS FOR PREPARING RACEMIC AND ENANTIOMERIC 1-(PYRIDYL)-2-CYCLOHEXYLETHYLAMINE<br/>[FR] PROCEDE DE PREPARATION DE 1-(PYRIDYL)-2-CYCLOHEXYLETHYLAMINE RACEMIQUE ET ENANTIOMORPHE
  申请人：——

  公开号：WO1996033173A2

  公开（公告）日：1996-10-24

  [EN] This invention relates to the preparation of racemic and enantiomeric 1-(pyridyl)-2-cyclohexylethylamine and, in particular, the separation of (+)-(S)- or (-)-(R)-1-(2-pyridyl)-2-cyclohexylethylamine from a racemic mixture of -1-(R,S)-(2-pyridyl)-2-cyclohexylethylamine. According to this invention, the separation of a racemic mixture of 1-(pyridyl)-2-cyclohexylethylamine is carried out using 3-bromocamphor-8-sulfonic acid (BCSA). This invention also relates to a process for preparing a racemic mixture of 1-(pyridyl)-2-cyclohexylethylamine and free BCSA from readily available starting materials.
  [FR] L'invention se rapporte à la préparation de 1-(pyridyl)-2-cyclohexyléthylamine racémique et énantiomorphe et, en particulier, à la séparation de (+)-(S)-1-(pyridyl)-2-cyclohexyléthylamine et de (-)-(R)-1-(pyridyl)-2-cyclohexyléthylamine à partir d'un mélange racémique de -1-(R,S)-(2-pyridyl)-2-cyclohexyléthylamine. Selon la présente invention, la séparation d'un mélange racémique de 1-(pyridyl)-2-cyclohexyléthylamine est réalisée au moyen de l'acide 3-bromocampho-8-sulfonique (BCSA). L'invention se rapporte également à un procédé de préparation d'un mélange racémique de 1-(pyridyl)-2-cyclohexyléthylamine et de BCSA libre à partir de matériaux de base facilement disponibles.