葡萄糖酸氯己定 - CAS号 18472-51-0

物化性质

密度：

1.06 g/mL at 25 °C(lit.)
溶解度：

水中的溶解度：50%(w/v)
最大波长(λmax)：

257nm(H2O)(lit.)
LogP：

-1.81 at 20.7℃
稳定性/保质期：

在常温常压下，该物质是稳定的。应避免与水溶液、碱金属及碱土金属以及多种有机和无机活性化学药品接触。

计算性质

辛醇/水分配系数(LogP)：

0.68
重原子数：

47
可旋转键数：

18
环数：

2.0
sp3杂化的碳原子比例：

0.39
拓扑面积：

316
氢给体数：

12
氢受体数：

9

安全信息

TSCA：

Yes
危险等级：

9
危险品标志：

N
安全说明：

S61
危险类别码：

R50/53
WGK Germany：

3,-
海关编码：

3004909090
危险品运输编号：

UN 3082 9 / PGIII
RTECS号：

DU1950000
包装等级：

III
危险类别：

9
危险标志：

GHS09
危险性描述：

H400,H411
危险性防范说明：

P273
储存条件：

常温下应密闭避光保存，并保持通风和干燥。

SDS

SDS：630c59a059d72980726475e9b7b06f26

查看

SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifiers
Product name : Chlorhexidine digluconate solution
REACH No. : A registration number is not available for this substance as the substance
or its uses are exempted from registration, the annual tonnage does not
require a registration or the registration is envisaged for a later
registration deadline.
Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances

SECTION 2: Hazards identification
Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Acute aquatic toxicity (Category 1), H400
Chronic aquatic toxicity (Category 2), H411
For the full text of the H-Statements mentioned in this Section, see Section 16.
Classification according to EU Directives 67/548/EEC or 1999/45/EC
N Dangerous for the R50/53
environment
For the full text of the R-phrases mentioned in this Section, see Section 16.
Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram
Signal word Warning
Hazard statement(s)
H400 Very toxic to aquatic life.
H411 Toxic to aquatic life with long lasting effects.
Precautionary statement(s)
P273 Avoid release to the environment.
Supplemental Hazard none
Statements
According to European Directive 67/548/EEC as amended.
Hazard symbol(s) N Dangerous for the environment
R-phrase(s)
R50/53 Very toxic to aquatic organisms, may cause long-term adverse effects in
the aquatic environment.
S-phrase(s)
S61 Avoid release to the environment. Refer to special instructions/ Safety
data sheets.
Other hazards - none

SECTION 3: Composition/information on ingredients
Mixtures
Hazardous ingredients according to Regulation (EC) No 1272/2008
Component Classification Concentration
D-Gluconic acid, compound with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-
tetraazatetradecanediamidine (2:1)
CAS-No. 18472-51-0 Acute Tox. 4; Aquatic Acute 1; 20 - 25 %
EC-No. 242-354-0 Aquatic Chronic 1; H302,
H410
Hazardous ingredients according to Directive 1999/45/EC
Component Classification Concentration
D-Gluconic acid, compound with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-
tetraazatetradecanediamidine (2:1)
CAS-No. 18472-51-0 Xn, N, R22R50/53 20 - 25 %
EC-No. 242-354-0
For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16

SECTION 4: First aid measures
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
section 11
Indication of any immediate medical attention and special treatment needed
no data available

SECTION 5: Firefighting measures
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, nitrogen oxides (NOx), Hydrogen chloride gas
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
no data available

SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.
For personal protection see section 8.
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the
environment must be avoided.
Methods and materials for containment and cleaning up
Keep in suitable, closed containers for disposal.
Reference to other sections
For disposal see section 13.

SECTION 7: Handling and storage
Precautions for safe handling
For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are
opened must be carefully resealed and kept upright to prevent leakage.
Recommended storage temperature: 2 - 8 °C
Light sensitive.
Specific end use(s)
A part from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
at the end of workday.
Personal protective equipment
Eye/face protection
Use equipment for eye protection tested and approved under appropriate government standards
such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Full contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Material tested:Dermatril® (KCL 740 / Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Material tested:Dermatril® (KCL 740 / Z677272, Size M)
data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, test method: EN374
If used in solution, or mixed with other substances, and under conditions which differ from EN 374,
contact the supplier of the CE approved gloves. This recommendation is advisory only and must
be evaluated by an industrial hygienist and safety officer familiar with the specific situation of
anticipated use by our customers. It should not be construed as offering an approval for any
specific use scenario.
Body Protection
Impervious clothing., The type of protective equipment must be selected according to the
concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
Respiratory protection not required. For nuisance exposures use type OV/AG (US) or type ABEK
(EU EN 14387) respirator cartridges. Use respirators and components tested and approved under
appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into
the environment must be avoided.

SECTION 9: Physical and chemical properties
Information on basic physical and chemical properties
a) Appearance Form: liquid
b) Odour no data available
c) Odour Threshold no data available
d) pH no data available
e) Melting point/freezing no data available
point
f) Initial boiling point and no data available
boiling range
g) Flash point no data available
h) Evaporation rate no data available
i) Flammability (solid, gas) no data available
j) Upper/lower no data available
flammability or
explosive limits
k) Vapour pressure no data available
l) Vapour density no data available
m) Relative density 1,06 g/cm3 at 25 °C
n) Water solubility no data available
o) Partition coefficient: n- no data available
octanol/water
p) Auto-ignition no data available
temperature
q) Decomposition no data available
temperature
r) Viscosity no data available
s) Explosive properties no data available
t) Oxidizing properties no data available
Other safety information
no data available

SECTION 10: Stability and reactivity
Reactivity
no data available
Chemical stability
Stable under recommended storage conditions.
Possibility of hazardous reactions
no data available
Conditions to avoid
no data available
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
Other decomposition products - no data available
In the event of fire: see section 5

SECTION 11: Toxicological information
Information on toxicological effects
Acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
no data available
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Additional Information
RTECS: Not available
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.

SECTION 12: Ecological information
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
Other adverse effects
Very toxic to aquatic life.

SECTION 13: Disposal considerations
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contaminated packaging
Dispose of as unused product.

SECTION 14: Transport information
UN number
ADR/RID: 3082 IMDG: 3082 IATA: 3082
UN proper shipping name
ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S. (D-Gluconic acid,
compound with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-
tetraazatetradecanediamidine (2:1))
IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S. (D-Gluconic acid,
compound with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-
tetraazatetradecanediamidine (2:1))
IATA: Environmentally hazardous substance, liquid, n.o.s. (D-Gluconic acid, compound with N,N''-
bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine (2:1))
Transport hazard class(es)
ADR/RID: 9 IMDG: 9 IATA: 9
Packaging group
ADR/RID: III IMDG: III IATA: III
Environmental hazards
ADR/RID: yes IMDG Marine Pollutant: yes IATA: yes
Special precautions for user
Further information
EHS-Mark required (ADR 2.2.9.1.10, IMDG code 2.10.3) for single packagings and combination
packagings containing inner packagings with Dangerous Goods > 5L for liquids or > 5kg for solids.

SECTION 15: Regulatory information
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
Safety, health and environmental regulations/legislation specific for the substance or mixture
no data available
Chemical Safety Assessment
For this product a chemical safety assessment was not carried out

SECTION 16: Other information
Full text of H-Statements referred to under sections 2 and 3.
Acute Tox. Acute toxicity
Aquatic Acute Acute aquatic toxicity
Aquatic Chronic Chronic aquatic toxicity
H302 Harmful if swallowed.
H400 Very toxic to aquatic life.
H410 Very toxic to aquatic life with long lasting effects.
H411 Toxic to aquatic life with long lasting effects.
Full text of R-phrases referred to under sections 2 and 3
N Dangerous for the environment
R22 Harmful if swallowed.
R50/53 Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic
environment.
Xn Harmful
Further information
Copyright 2013 Co. LLC. License granted to make unlimited paper copies for internal use
only.
The above information is believed to be correct but does not purport to be all inclusive and shall be
used only as a guide. The information in this document is based on the present state of our knowledge
and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Corporation and its Affiliates shall not be held
liable for any damage resulting from handling or from contact with the above product. See
and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

制备方法与用途

葡萄糖酸氯已定消毒液

葡萄糖酸氯己定消毒液属低效消毒剂，具有快速杀灭化脓菌、肠道致病菌、医院感染常见病原菌以及空气中的致病菌和致病性酵母菌的能力。适用于手部及其他部位皮肤的长效杀菌防护。

作用 杀菌效果

葡萄糖酸氯己定是一种低效广谱杀菌剂，具有速效杀菌作用，能有效杀灭化脓性球菌、肠道致病菌、医院感染常见病原菌和空气中的致病菌及酵母菌。此外，它还适用于注射部位皮肤、手术部位皮肤的长效杀菌防护。

安全特性

该药物无明显毒副作用，药性温和，易于清洁且无异味，不会污染衣物，并对皮肤无刺激性。主要成分包括葡萄糖酸氯己定和乙醇，能迅速挥发，1分钟内即可达到消毒效果。使用后涂擦处皮肤容易干燥，便于进行下一步治疗操作。

作用机制 抗菌特性

氯己定是一种阳离子型表面活性剂，具有广谱抗菌作用。其作用机理是改变细菌细胞膜的通透性，使其失去功能从而发挥抑菌或杀菌效果。某些葡萄球菌、变异链球菌、唾液链球菌、白念珠菌、大肠埃希菌和厌氧丙酸菌对其高度敏感；嗜血链球菌中度敏感；变形杆菌属、假单胞菌属、克雷伯杆菌属及革兰阴性球菌（如韦永球菌）低度敏感。与苯扎溴铵等消毒药相比，葡萄糖酸氯己定对革兰阳性和阴性菌的抗菌作用更强，在血清和血液存在时仍有效。

药代动力学 吸收与释放

葡萄糖酸氯己定溶液带正电荷，通过口腔含漱吸附在牙齿、牙斑及口腔粘膜表面，并逐渐从这些部位扩散释出。胃肠道吸收很少，大部分随粪便排出。

药物相互作用

葡萄糖酸氯己定含漱液不宜与碳酸氢钠（小苏打）或碘化钾同时使用，与其他药物共用可能产生相互作用，请咨询医师或药师以确保安全。

制备方法

一种复方含漱液由以下原料制成：聚山梨酯80 5.5g、甲硝唑原粉1.2g、乙醇220g、香蕉香精2.0g、薄荷水40g、糖精钠0.7g、柠檬黄色素0.025g、甘油315g、聚乙二醇400 275g、葡萄酸氯己定（质量分数为5%）125g、纯化水适量。

制备步骤

将香蕉香精、薄荷水加入到料液A中，在搅拌速度60转/分的条件下搅拌20分钟。
将糖精钠用50ml纯化水溶解，得料液B。
将柠檬黄色素用50ml纯化水溶解，得料液C。
在容器D中加入甘油、聚乙二醇400及质量分数为5%的葡萄酸氯己定，在搅拌速度60转/分的情况下边搅拌边依次加入，并继续搅拌5分钟至均匀，得料液D。
将所有材料混合均匀后，用纯化水调整总量至5000ml并搅拌均匀。

用途

该消毒防腐药具有强效的广谱抑菌、杀菌作用，适用于外用手和皮肤消毒及冲洗创口。

类别与危险性 毒性分级

有毒物品

急性毒性

口服：大鼠LD50：2000毫克/公斤；小鼠LD50：1260毫克/公斤

可燃性危险特性

热分解时排出有毒氮氧化物、氯化物烟雾

储运特性

库房低温通风干燥

灭火剂

水、二氧化碳、泡沫、干粉

反应信息

作为反应物：

描述：

葡萄糖酸氯己定在 calcium(II) nitrate tetrahydrate 作用下，以水为溶剂，生成 chlorhexidine nitrate

参考文献：

名称：

[EN] ANTIBACTERIAL MICRO- AND NANOPARTICLES COMPRISING A CHLORHEXIDINE SALT, METHOD OF PRODUCTION AND USES THEREOF
[FR] MICROPARTICULES ET NANOPARTICULES ANTIBACTÉRIENNES COMPRENANT UN SEL DE CHLORHEXIDINE, PROCÉDÉ DE PRODUCTION ET UTILISATIONS ASSOCIÉES

摘要：

本发明公开了含有氯己定盐和阴离子的抗微生物微米或纳米颗粒，以及制备抗微生物微米或纳米颗粒的方法。盐中的阴离子是从磷、碳、氮和硫的氧酸根和部分氢化氧酸根中选择的。

公开号：

WO2014184582A1

点击查看最新优质反应信息

文献信息

[EN] S-NITROSOMERCAPTO COMPOUNDS AND RELATED DERIVATIVES<br/>[FR] COMPOSÉS DE S-NITROSOMERCAPTO ET DÉRIVÉS APPARENTÉS

申请人：GALLEON PHARMACEUTICALS INC

公开号：WO2009151744A1

公开（公告）日：2009-12-17

The present invention is directed to mercapto-based and S- nitrosomercapto-based SNO compounds and their derivatives, and their use in treating a lack of normal breathing control, including the treatment of apnea and hypoventilation associated with sleep, obesity, certain medicines and other medical conditions.

本发明涉及基于巯基和S-亚硝基巯基的SNO化合物及其衍生物，以及它们在治疗正常呼吸控制缺失方面的用途，包括治疗与睡眠、肥胖、某些药物和其他医疗状况相关的呼吸暂停和低通气。
Substituted pyrroline kinase inhibitors

申请人：——

公开号：US20040192718A1

公开（公告）日：2004-09-30

The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.

本发明涉及新型取代吡咯烯化合物，可用作激酶或双激酶抑制剂，并用于治疗或改善激酶或双激酶介导的疾病的方法。
Drug efflux pump inhibitor

申请人：DAIICHI PHARMACEUTICAL CO., LTD

公开号：US20030092720A1

公开（公告）日：2003-05-15

A medicament for preventive and/or therapeutic treatment of a microbial infection which comprises as an active ingredient a compound represented by the following general formula (I): 1 wherein, R 1 and R 2 represent hydrogen atom, a halogen atom, hydroxyl group or the like, W 1 represents —CH═CH—, —CH 2 O—, —CH 2 CH 2 — or the like; R 3 represents hydrogen atom, a halogen atom, hydroxyl group or an amino group; R 4 represents hydrogen atom, a group of —OZ 0-4 R 5 (Z 0-4 represents an alkylene group, a fluorine-substituted alkylene group or a single bond, and R 5 represents a cyclic alkyl group, an aryl group or the like); W 2 represents a single bond or —C(R 8 )═C(R 9 )— (R 8 and R 9 represent hydrogen atom, a halogen atom, a lower alkyl group or the like, Q represents an acidic group, but W 2 and Q may together form vinylidenethiazolidinedione or an equivalent heterocyclic ring; m and n represent an integer of 0 to 2, and q represents an integer of 0 to 3.

一种用于预防和/或治疗微生物感染的药物，其活性成分表示为以下一般式(I)的化合物：其中，R1和R2代表氢原子、卤素原子、羟基或类似物，W1代表—CH═CH—、—CH2O—、—CH2CH2—或类似物；R3代表氢原子、卤素原子、羟基或氨基；R4代表氢原子、—OZ0-4R5（Z0-4代表烷基链、氟取代的烷基链或单键，R5代表环烷基、芳基或类似物）；W2代表单键或—C(R8)═C(R9)—（R8和R9代表氢原子、卤素原子、较低烷基或类似物，Q代表酸性基团，但W2和Q可以共同形成乙烯基噻唑二酮或等效的杂环环；m和n代表0到2的整数，q代表0到3的整数。
FLAP MODULATORS

申请人：JANSSEN PHARMACEUTICA NV

公开号：US20140221310A1

公开（公告）日：2014-08-07

The present invention relates to compounds of Formula (I), or a form thereof, wherein ring A, R 1 , L and R 2 are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.

本发明涉及式（I）化合物，或其形式，其中环A，R1，L和R2如本文所定义，作为FLAP调节剂有用。该发明还涉及包含式（I）化合物的药物组合物。制备和使用式（I）化合物的方法也属于本发明的范围。
[EN] PEPTIDE-BASED MULTIPLE-DRUG DELIVERY VEHICLE<br/>[FR] VÉHICULE D'ADMINISTRATION DE MÉDICAMENTS MULTIPLES À BASE DE PEPTIDES

申请人：ARIEL-UNIVERSITY RES AND DEV COMPANY LTD

公开号：WO2017068577A1

公开（公告）日：2017-04-27

A molecular structure comprising a targeting moiety, a multi-functional peptide platform and a plurality of controllably released bioactive agents attached thereto is provided herein.

本文提供了一种包括靶向基团、多功能肽平台和附着在其上的多种可控释放的生物活性剂的分子结构。

葡萄糖酸氯己定 | 18472-51-0

物质功能分类

分子结构分类

物化性质

计算性质

安全信息

SDS

制备方法与用途

反应信息

文献信息

同类化合物

相关功能分类

相关结构分类

热门分子