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水杨醛
二溴甲烷
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苄基(2-氧代-5-苯基-2,3-二氢-1H-苯并[E][1,4]二氮杂-3-基)氨基甲酸叔丁酯 | 108895-98-3

分子结构分类

有机化合物 - 有机杂环化合物 - 苯二氮卓类

中文名称

苄基(2-氧代-5-苯基-2,3-二氢-1H-苯并[E][1,4]二氮杂-3-基)氨基甲酸叔丁酯

中文别名

——

英文名称

benzyl 2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamate

英文别名

1,3-dihydro-5-phenyl-3(R,S)-<(benzyloxycarbonyl)-amino>-2H-1,4-benzodiazepin-2-one；(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamic acid benzyl ester；(Z)-benzyl 2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamate；1,3-Dihydro-5-phenyl-3(R,S)-[(benzyloxycarbonyl)-amino]-2H-1,4-benzodiazepin-2-one；Benzyl (2-oxo-5-phenyl-2,3-dihydro-1h-benzo[e][1,4]diazepin-3-yl)carbamate；benzyl N-(2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl)carbamate

苄基(2-氧代-5-苯基-2,3-二氢-1H-苯并[E][1,4]二氮杂-3-基)氨基甲酸叔丁酯化学式

CAS

108895-98-3

化学式

C₂₃H₁₉N₃O₃

mdl

——

分子量

385.422

InChiKey

SJZIESNYFPDCPM-UHFFFAOYSA-N

BEILSTEIN

——

EINECS

——

物化性质

熔点：

212-213 °C
沸点：

619.7±55.0 °C(Predicted)
密度：

1.26±0.1 g/cm3(Predicted)

计算性质

辛醇/水分配系数(LogP)：

3.8
重原子数：

29
可旋转键数：

5
环数：

4.0
sp3杂化的碳原子比例：

0.09
拓扑面积：

79.8
氢给体数：

2
氢受体数：

4

SDS

SDS：47d8dcce9e05ba0f9564c800f1ca8814

查看

上下游信息

上游原料

中文名称	英文名称	CAS号	化学式	分子量
——	(+/-) 3-[N-carbobenzyloxy]amino-2,3-dihydro-1-[4-methoxybenzyl]-2-oxo-5-phenyl-1H-1,4-benzodiazepine	174698-38-5	C₃₁H₂₇N₃O₄	505.573
——	2-α-(benzyloxycarbonyl)glycinyl)amino>benzophenone	108895-97-2	C₂₃H₂₁N₃O₄	403.437
——	2-α-(benzyloxycarbonyl)-glycinyl)-amino>-benzophenone	106849-44-9	C₂₆H₂₆N₂O₄S	462.569

下游产品

中文名称	英文名称	CAS号	化学式	分子量
——	1,3-Dihydro-5-phenyl-3(S)-<<(R)-α-methylbenzyloxycarbonyl>amino>-2H-1,4-benzodiazepin-2-one	161443-31-8	C₂₄H₂₁N₃O₃	399.449
——	1,3-Dihydro-5-phenyl-3(R)-<<(R)-α-methylbenzyloxycarbonyl>amino>-2H-1,4-benzodiazepin-2-one	——	C₂₄H₂₁N₃O₃	399.449
——	1,3-dihydro-1-methyl-5-phenyl-3(R,S)-<(benzyloxycarbonyl)-amino>-2H-1,4-benzodiazepin-2-one	106849-47-2	C₂₄H₂₁N₃O₃	399.449
——	(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamic acid tert-butyl ester	168162-29-6	C₂₀H₂₁N₃O₃	351.405
——	benzyl N-[1-[2-(dimethylamino)ethyl]-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]carbamate	136051-18-8	C₂₇H₂₈N₄O₃	456.544
——	benzyl N-[1-(2-hydroxyethyl)-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]carbamate	153826-05-2	C₂₅H₂₃N₃O₄	429.475
——	1,3-Dihydro-1-methyl-5-phenyl-3(S)-<<(R)-α-methylbenzyloxycarbonyl>amino>-2H-1,4-benzodiazepin-2-one	161365-75-9	C₂₅H₂₃N₃O₃	413.476
——	benzyl N-[2-oxo-1-(2-oxoethyl)-5-phenyl-3H-1,4-benzodiazepin-3-yl]carbamate	1345046-37-8	C₂₅H₂₁N₃O₄	427.459
——	1,3-dihydro-1-cyanomethyl-3-[(benzyloxycarbonyl)amino]-5-phenyl-2H-1,4-benzodiazepin-2-one	145659-79-6	C₂₅H₂₀N₄O₃	424.459
——	benzyl N-[2-oxo-1-(3-oxopropyl)-5-phenyl-3H-1,4-benzodiazepin-3-yl]carbamate	1345046-38-9	C₂₆H₂₃N₃O₄	441.486
——	3-benzyloxycarbonylamino-1-isobutyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one	820215-09-6	C₂₇H₂₇N₃O₃	441.53
——	benzyl N-[1-(2-amino-2-oxoethyl)-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]carbamate	1060742-19-9	C₂₅H₂₂N₄O₄	442.474
——	(1(2-(Ethylamino)-2-oxoethyl)-2,3-dihydro-5-phenyl-2-oxo-1H-1,4-benzodiazepin-3-yl)-carbamic acid phenylmethyl ester	119487-63-7	C₂₇H₂₆N₄O₄	470.528
——	1(Carboxymethyl)-1,3-Dihydro-5-phenyl-3(R,S)-[(benzyloxycarbonyl)-amino]2H-1,4-benzodiazepin-2-one	172968-04-6	C₂₅H₂₁N₃O₅	443.459
——	3-(benzoxycarbonyl)amino-2,3-dihydro-1-(4,4,4-trifluorobutyl)-5-phenyl-1H-1,4-benzodiazepin-2-one	209986-66-3	C₂₇H₂₄F₃N₃O₃	495.501
N-(2-氧代-5-苯基-2,3-二氢-1H-苯并[e][1,4]二氮杂革-3-基)-乙酰胺	3-acetylamino-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one	70890-53-8	C₁₇H₁₅N₃O₂	293.325
——	N,N-diethyl-3(R,S)-<(benzyloxycarbonyl)amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetamide	119487-44-4	C₂₉H₃₀N₄O₄	498.582
——	1,3-dihydro-1-chlorocarbonylmethyl-3(phenylmethyloxycarbonyl)amino-5-phenyl-2H-1,4-benzodiazepin-2-one	119487-61-5	C₂₅H₂₀ClN₃O₄	461.904
——	(2,3-Dihydro-1-(2-(4-methyl-1-piperazinyl)-2-oxoethyl)-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-carbamic acid phenylmethyl ester	119487-35-3	C₃₀H₃₁N₅O₄	525.607
——	(2,3-Dihydro-2-oxo-1-(2-oxo-2-((phenylmethyl)amino)ethyl)-5-phenyl-1H-1,4-benzodiazepin-3-yl)-carbamic acid phenylmethyl ester	119487-60-4	C₃₂H₂₈N₄O₄	532.599
——	N-isopropyl-2-{2-oxo-5-phenyl-3-[(benzyloxycarbonyl)amino]-2,3-dihydro-benzo[e][1,4]diazepin-1-yl}-N-phenyl acetamide	173459-46-6	C₃₄H₃₂N₄O₄	560.652
——	ethyl 3-<(benzyloxycarbonyl)amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetate	119487-58-0	C₂₇H₂₅N₃O₅	471.513
——	benzyl N-[1-(3-methyl-2-oxobutyl)-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]carbamate	155412-61-6	C₂₈H₂₇N₃O₄	469.54
——	phenylmethyl N-[2,3-dihydro-5-phenyl-2-thioxo-1H-1,4-benzodiazepin-3-yl]carbamate	111113-10-1	C₂₃H₁₉N₃O₂S	401.489
——	benzyl N-[2-oxo-1-(2-oxo-2-pyrrolidin-1-ylethyl)-5-phenyl-3H-1,4-benzodiazepin-3-yl]carbamate	1060635-03-1	C₂₉H₂₈N₄O₄	496.566
——	benzyl N-[1-(3,3-dimethyl-2-oxobutyl)-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]carbamate	152665-63-9	C₂₉H₂₉N₃O₄	483.567
——	N-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-isobutyramide	——	C₁₉H₁₉N₃O₂	321.379
——	1,1-diethyl-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-urea	——	C₂₀H₂₂N₄O₂	350.42
——	benzyl N-[1-(3-ethyl-2-oxopentyl)-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]carbamate	152665-66-2	C₃₀H₃₁N₃O₄	497.594
——	1,3-Dihydro-1-(1H-tetrazol-5-yl)methyl-3-[(benzyloxycarbonyl)amino]-5-phenyl-2H-1,4-benzodiazepin-2-one	145659-80-9	C₂₅H₂₁N₇O₃	467.487
——	2,3-dihydro-alpha-methyl-2-oxo-5-phenyl-3-((phenylmethoxy)carbonyl)amino-1H-1,4-benzodiazepine-1-acetic acid	119506-55-7	C₂₆H₂₃N₃O₅	457.486
——	benzyl N-[1-(2-cyclobutyl-2-oxoethyl)-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]carbamate	152665-61-7	C₂₉H₂₇N₃O₄	481.551
——	benzyl N-[1-(3-cyclohexyl-2-oxopropyl)-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]carbamate	155412-31-0	C₃₂H₃₃N₃O₄	523.632
3-氨基-5-苯基-1,3-二氢-2H-1,4-苯并二氮杂革-2-酮	3-amino-5-phenyl-1,3-dihydrobenzo[e][1,4]diazepin-2-one	103343-47-1	C₁₅H₁₃N₃O	251.288
——	(S)-3-amino-5-phenyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one	253135-95-4	C₁₅H₁₃N₃O	251.288
——	3-(Benzoxycarbonyl)amino-2,3-dihydro-1-(2-oxo-2-phenylethyl)-5-phenyl-1H-1,4-benzodiazepin-2-one	209986-63-0	C₃₁H₂₅N₃O₄	503.557
——	benzyl N-[1-(2-cyclohexyl-2-oxoethyl)-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]carbamate	152666-04-1	C₃₁H₃₁N₃O₄	509.605
——	(+/-) 3-[N-carbobenzyloxy]amino-2,3-dihydro-1-[4-methoxybenzyl]-2-oxo-5-phenyl-1H-1,4-benzodiazepine	174698-38-5	C₃₁H₂₇N₃O₄	505.573
——	benzyl N-[1-(2-cyclopentyl-2-oxoethyl)-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]carbamate	152665-68-4	C₃₀H₂₉N₃O₄	495.578
——	benzyl N-[1-(2-cycloheptyl-2-oxoethyl)-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]carbamate	152665-70-8	C₃₂H₃₃N₃O₄	523.632
——	N-(2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-benzamide	150964-48-0	C₂₂H₁₇N₃O₂	355.396
——	benzyl N-[1-(1-chloro-1-oxopropan-2-yl)-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]carbamate	1056010-02-6	C₂₆H₂₂ClN₃O₄	475.931
1H-1,4-苯并二氮卓-1-乙酸,3-[[(1,1-二甲基乙氧基)羰基]氨基]-2,3-二氢-2-羰基-5-苯基-	(3-tert-butoxycarbonylamino-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)acetic acid	164336-13-4	C₂₂H₂₃N₃O₅	409.442
——	benzyl N-[1-[2-(1-methylcyclohexyl)-2-oxoethyl]-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]carbamate	155412-34-3	C₃₂H₃₃N₃O₄	523.632
——	benzyl N-[1-[2-(1-methylcyclopentyl)-2-oxoethyl]-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]carbamate	155412-46-7	C₃₁H₃₁N₃O₄	509.605
——	(1-(2-(Diethylamino)-1-methyl-2-oxoethyl)-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-carbamic acid phenylmethyl ester	119506-56-8	C₃₀H₃₂N₄O₄	512.608
——	benzyl N-[1-(3-cyclohexyl-3-methyl-2-oxobutyl)-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]carbamate	155412-55-8	C₃₄H₃₇N₃O₄	551.685
——	4-methoxy N-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)benzamide	——	C₂₃H₁₉N₃O₃	385.422
——	(R,S)-2,3-dihydro-1-((2-methyl-1,3,4-triazol-5-yl)methyl)-2-oxo-3-((benzyloxycarbonyl)amino)-5-phenyl-1H-1,4-benzodiazepin-2-one	145874-82-4	C₂₇H₂₄N₆O₃	480.526
——	(3-tert-butoxycarbonylamino-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)acetic acid ethyl ester	177784-09-7	C₂₄H₂₇N₃O₅	437.495
——	6-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-ylamino)-6-oxohexanoic acid	1449305-60-5	C₂₂H₂₃N₃O₄	393.442
——	9-(1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-ylamino)-9-oxononanoic acid	1449305-58-1	C₂₅H₂₉N₃O₄	435.523
——	7-(1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-ylamino)-7-oxoheptanoic acid	1449305-61-6	C₂₃H₂₅N₃O₄	407.469
——	8-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylamino)-8-oxooctanoic acid	1346678-79-2	C₂₄H₂₇N₃O₄	421.496
——	(R)-8-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylamino)-8-oxooctanoic acid	1449305-66-1	C₂₄H₂₇N₃O₄	421.496
——	N¹-hydroxy-N⁸-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diazepin-3-yl)nonanediamide	1449305-62-7	C₂₅H₃₀N₄O₄	450.538
——	N¹-Hydroxy-N⁹-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diazepin-3-yl)octanediamide	1229611-67-9	C₂₄H₂₈N₄O₄	436.511
——	N¹-Hydroxy-N⁷-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diazepin-3-yl)heptanediamide	1449305-64-9	C₂₃H₂₆N₄O₄	422.484
——	N-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-3-trifluoromethyl-benzamide	——	C₂₃H₁₆F₃N₃O₂	423.394
——	N¹-Hydroxy-N⁶-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1Hbenzo[e][1,4]diazepin-3-yl)hexanediamide	1449305-63-8	C₂₂H₂₄N₄O₄	408.457
3-氨基-1-甲基-5-苯基-1,3-二氢-2H-1,4-苯并二氮杂-2-酮	3-amino-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one	103421-61-0	C₁₆H₁₅N₃O	265.315
——	(S)-3-amino-1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one	103343-66-4	C₁₆H₁₅N₃O	265.315
——	(3R)-3-amino-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one	103343-65-3	C₁₆H₁₅N₃O	265.315
——	ethyl 6-[(1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl)amino]-6-oxohexanoate	1449305-59-2	C₂₄H₂₇N₃O₄	421.496
——	ethyl 8-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylamino)-8-oxooctanoate	1229611-66-8	C₂₆H₃₁N₃O₄	449.55
——	(R)-ethyl 8-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylamino)-8-oxooctanoate	1229611-69-1	C₂₆H₃₁N₃O₄	449.55
——	methyl (2S)-1-[2-[2-oxo-5-phenyl-3-(phenylmethoxycarbonylamino)-3H-1,4-benzodiazepin-1-yl]acetyl]pyrrolidine-2-carboxylate	1052161-52-0	C₃₁H₃₀N₄O₆	554.602
——	1,3-dihydro-1-(2-hydroxyethyl)-3-(R,S)-amino-5-phenyl-1H-1,4-benzodiazepin-2-one	136051-17-7	C₁₇H₁₇N₃O₂	295.341
——	(R,S)-N-(2,3-dihydro-1-(2-hydroxyethyl)-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-N'-(3-methylphenyl)urea	136051-13-3	C₂₅H₂₄N₄O₃	428.491
——	benzyl 2-oxo-5-phenyl-1-(pyridin-2-yl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamate	1581718-81-1	C₂₈H₂₂N₄O₃	462.508
——	N-[2-oxo-1-(2-oxoethyl)-5-phenyl-3H-1,4-benzodiazepin-3-yl]-2-phenylacetamide	1345046-44-7	C₂₅H₂₁N₃O₃	411.46
——	2-ethoxy-N-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-benzamide	——	C₂₄H₂₁N₃O₃	399.449
——	[2-Oxo-5-phenyl-3-(3-m-tolyl-ureido)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-acetic acid	166388-36-9	C₂₅H₂₂N₄O₄	442.474
——	N-[2-oxo-1-(2-oxoethyl)-5-phenyl-3H-1,4-benzodiazepin-3-yl]-3-phenylpropanamide	1345046-43-6	C₂₆H₂₃N₃O₃	425.487
——	N-[2-oxo-1-(2-oxoethyl)-5-phenyl-3H-1,4-benzodiazepin-3-yl]benzamide	1345046-40-3	C₂₄H₁₉N₃O₃	397.433
——	3-(R,S)-<<((4-chlorophenyl)amino)carbonyl>amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetic acid	119487-54-6	C₂₄H₁₉ClN₄O₄	462.892
——	2-(4-fluorophenyl)-N-[2-oxo-1-(2-oxoethyl)-5-phenyl-3H-1,4-benzodiazepin-3-yl]acetamide	1345046-46-9	C₂₅H₂₀FN₃O₃	429.451
——	4-methyl-N-[2-oxo-1-(2-oxoethyl)-5-phenyl-3H-1,4-benzodiazepin-3-yl]benzamide	1345046-47-0	C₂₅H₂₁N₃O₃	411.46
(2R,3S)-N1-[(3S)-2,3-二氢-1-甲基-2-氧代-5-苯基-1H-1,4-苯并二氮杂卓-3-基]-2,3-二(3,3,3-三氟丙基)丁二酰胺	BMS-906024	1401066-79-2	C₂₆H₂₆F₆N₄O₃	556.508
——	(R,S)-N,N-diethyl-2-(2,3-dihydro-3-<<((3-methylphenyl)amino)carbonyl>amino>-2-oxo-5-phenyl-1H-1,4-benzodiazepin-1-yl)glycine ethyl ester	——	C₃₁H₃₅N₅O₄	541.65
——	ethyl 2-[3-[(3-methylphenyl)carbamoylamino]-2-oxo-5-phenyl-3H-1,4-benzodiazepin-1-yl]acetate	177784-11-1	C₂₇H₂₆N₄O₄	470.528
——	2-(3-Amino-2-oxo-5-phenyl-2,3-dihydro-benzo[e][1,4]diazepin-1-yl)-N-isopropyl-N-phenyl-acetamide	760922-81-4	C₂₆H₂₆N₄O₂	426.518
——	ethyl 3-(R,S)-<<((4-chlorophenyl)amino)carbonyl>amino>-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-1-acetate	118018-39-6	C₂₆H₂₃ClN₄O₄	490.946
——	tert-butyl N-[4-[2-oxo-2-[[2-oxo-1-(2-oxoethyl)-5-phenyl-3H-1,4-benzodiazepin-3-yl]amino]ethyl]phenyl]carbamate	1345046-45-8	C₃₀H₃₀N₄O₅	526.592
——	(2S,3R)-6,6,6-trifluoro-3-(((35)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)carbamoyl)-2-(3,3,3-trifluoropropyl)hexanoic acid	1401067-34-2	C₂₆H₂₅F₆N₃O₄	557.493
——	N-[2-oxo-1-(2-oxoethyl)-5-phenyl-3H-1,4-benzodiazepin-3-yl]furan-2-carboxamide	1345046-42-5	C₂₂H₁₇N₃O₄	387.395
——	N-(2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-(E)-(2R,3R,4S,5R)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide	958488-80-7	C₂₇H₃₃N₃O₆	495.576
——	{1-[((3S)-2-benzyloxy-5-oxo-tetrahydrofuran-3-ylcarbamoyl)methyl]-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl}carbamic acid tert-butyl ester	821800-05-9	C₃₃H₃₄N₄O₇	598.656
——	(R)-3-Amino-1-(3,3-dimethyl-2-oxo-butyl)-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one	155412-24-1	C₂₁H₂₃N₃O₂	349.433
——	3-hydroxy-4-methyl-N-[2-oxo-1-(2-oxoethyl)-5-phenyl-3H-1,4-benzodiazepin-3-yl]benzamide	1345046-49-2	C₂₅H₂₁N₃O₄	427.459
——	N-[2-oxo-1-(2-oxoethyl)-5-phenyl-3H-1,4-benzodiazepin-3-yl]pyridine-2-carboxamide	1345046-41-4	C₂₃H₁₈N₄O₃	398.421
——	2,4-dichloro-N-[2-oxo-1-(2-oxoethyl)-5-phenyl-3H-1,4-benzodiazepin-3-yl]benzamide	1345046-48-1	C₂₄H₁₇Cl₂N₃O₃	466.323
——	(2S)-N-[1-(2-amino-2-oxoethyl)-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-3-(3,4-difluorophenyl)-2-methylpropanamide	376583-17-4	C₂₇H₂₄F₂N₄O₃	490.509
——	tert-butyl (2S,3R)-6,6,6-trifluoro-3-(((35)-1-methyl-2-oxo-5-phenyl2,3-dihydro-1H-1,4-benzodiazepin-3-yl)carbamoyl)-2-(3,3,3-trifluoropropyl)hexanoate	1401067-05-7	C₃₀H₃₃F₆N₃O₄	613.6
地伐西匹	devazepide	103420-77-5	C₂₅H₂₀N₄O₂	408.459
——	1H-Indole-2-carboxylic acid ((R)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide	103420-82-2	C₂₅H₂₀N₄O₂	408.459
——	3-amino-1-(2-cyclopentyl-2-oxoethyl)-5-phenyl-3H-1,4-benzodiazepin-2-one	150007-40-2	C₂₂H₂₃N₃O₂	361.444
——	3-amino-1-(4-methoxybenzyl)-5-phenyl-1,3-dihydro-2H-benzo [e][1,4]diazepin-2-one	——	C₂₃H₂₁N₃O₂	371.439
——	1,3-Dihydro-1-[1-(2,4-dinitrophenyl)-4-imidazolyl]-methyl-3-[(benzyloxycarbonyl)amino]-5-phenyl-2H-1,4-benzodiazepin-2-one	145874-67-5	C₃₃H₂₅N₇O₇	631.604
——	4-methyl-N-[2-oxo-1-(2-oxoethyl)-5-phenyl-3H-1,4-benzodiazepin-3-yl]benzenesulfonamide	1345046-66-3	C₂₄H₂₁N₃O₄S	447.514

反应信息

作为反应物：

描述：

苄基(2-氧代-5-苯基-2,3-二氢-1H-苯并[E][1,4]二氮杂-3-基)氨基甲酸叔丁酯在氢溴酸、 sodium hydride 、 1-羟基苯并三唑、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺、三乙胺、 N,N-二异丙基乙胺作用下，以二氯甲烷、溶剂黄146 、 N,N-二甲基甲酰胺、乙腈为溶剂，反应 4.17h，生成地伐西匹

参考文献：

名称：

An Improved Synthesis and Resolution of 3-Amino-1,3-dihydro-5-phenyl-2H- 1,4-benzodiazepin-2-ones

摘要：

DOI：

10.1021/jo00108a044
作为产物：

描述：

2-氨基二苯甲酮在 N-甲基吗啉、 ammonium acetate 、氨、溶剂黄146 、 mercury dichloride 、氯甲酸异丁酯作用下，以四氢呋喃、二氯甲烷为溶剂，反应 16.0h，生成苄基(2-氧代-5-苯基-2,3-二氢-1H-苯并[E][1,4]二氮杂-3-基)氨基甲酸叔丁酯

参考文献：

名称：

caspase-3的有效和选择性拟肽抑制剂的设计与合成。

摘要：

在本文中，我们报告了新型有效且选择性的caspase-3抑制剂的合成和表征，caspase-3是半胱氨酸蛋白酶caspase家族的成员，在许多人类疾病中起着重要作用。该分子代表3（S）-乙酰氨基-N- [1-[（（（（3S）-2-hydroxy-5-oxo-tetrahydrofuran-3-yl）carbamoyl）methyl] -2-oxo-5-phenyl- 2,3-二氢-1H-苯并[e] [1,4]二氮杂pin-3-基]琥珀酸，四肽Ac-DEVD-H的单环构象受约束形式，其中1,4-苯并二氮杂核为在肽序列内部引入。

DOI：

10.1021/jm049248f

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文献信息

[EN] 5-PHENYL-LH-BENZ0 [E] [1, 4] DIAZEPINE COMPOUNDS SUBSTITUTED WITH AN HYDROXAMIC ACID GROUP AS HISTONE DEACETYLASE INHIBITORS<br/>[FR] COMPOSÉS DE 5-PHÉNYL-LH-BENZO [E] [1, 4] DIAZÉPINE SUBSTITUÉS AVEC UN GROUPE D'ACIDE HYDROXAMIQUE EN TANT QU'INHIBITEURS D'HISTONE DÉACÉTYLASE

申请人：UNIV FIRENZE

公开号：WO2009081349A1

公开（公告）日：2009-07-02

Novel hydroxamate histone deacetylase inhibitors of formula (I) wherein X is C=O or CH2 used as antineoplastic agent.

新型羟肟酸组蛋白去乙酰化酶抑制剂的化学式(I)，其中X为C=O或CH2，用作抗肿瘤药物。
[EN] COMBINATION PHARMACEUTICAL AGENTS AS RSV INHIBITORS<br/>[FR] AGENTS PHARMACEUTIQUES EN COMBINAISON EN TANT QU'INHIBITEURS DE RSV

申请人：ENANTA PHARM INC

公开号：WO2019067864A1

公开（公告）日：2019-04-04

The present invention relates to pharmaceutical agents administered to a subject either in combination or in series for the treatment of a Respiratory Syncytial Virus (RSV) infection, wherein treatment comprises administering a compound effective to inhibit the function of the RSV and an additional compound or combinations of compounds having anti-RSV activity.

本发明涉及用于治疗呼吸道合胞病毒（RSV）感染的药物剂，该药物剂可以单独或连续给予受试者，治疗包括给予一种有效抑制RSV功能的化合物以及具有抗RSV活性的另一种化合物或化合物组合。
Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds

申请人：——

公开号：US20020045747A1

公开（公告）日：2002-04-18

Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

公开了抑制β-淀粉样肽释放和/或其合成的化合物，因此可用于治疗阿尔茨海默病。还公开了包含抑制β-淀粉样肽释放和/或其合成的化合物的药物组合物，以及使用这些药物组合物预防性和治疗性治疗阿尔茨海默病的方法。
Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting &bgr;-amyloid peptide release and/or its synthesis by use of such compounds

申请人：Elan Pharmaceuticals, Inc.

公开号：US06528505B1

公开（公告）日：2003-03-04

Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

公开了抑制β-淀粉样肽释放和/或其合成的化合物，因此可用于治疗阿尔茨海默病。还公开了包含抑制β-淀粉样肽释放和/或其合成的化合物的药物组合物，以及使用这些药物组合物预防性和治疗性治疗阿尔茨海默病的方法。
[EN] BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS<br/>[FR] DÉRIVÉS BENZODIAZÉPINE UTILISÉS COMME INHIBITEURS DU VIRUS RESPIRATOIRE SYNCYTIAL (RSV)

申请人：ENANTA PHARM INC

公开号：WO2017015449A1

公开（公告）日：2017-01-26

The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV infection. The invention also relates to methods of treating an RSV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

本发明公开了化合物的结构式（I），或其药学上可接受的盐、酯或前药：这些化合物抑制呼吸道合胞病毒（RSV）。本发明还涉及包含上述化合物的药物组合物，用于治疗患有RSV感染的受试者。该发明还涉及通过给予包含本发明化合物的药物组合物来治疗受试者的RSV感染的方法。