N-(3β-hydroxy-urs-12-en-28-oyl)-1-amino-N-glycyl-2-aminoethane | 1351856-49-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: N-(3β-hydroxy-urs-12-en-28-oyl)-1-amino-N-glycyl-2-aminoethane
• 英文别名: (1S,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-N-[2-[(2-aminoacetyl)amino]ethyl]-10-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxamide
• CAS: 1351856-49-9
• 化学式: C₃₄H₅₇N₃O₃
• 分子量: 555.845
• InChiKey: KWLIXPDANJYNOY-QXQWIYNLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  40
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  104
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  熊果酸 在 吡啶 、 甲醇 、 4-二甲氨基吡啶 、 草酰氯 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 、 sodium hydroxide 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 二氯甲烷 为溶剂， 生成 N-(3β-hydroxy-urs-12-en-28-oyl)-1-amino-N-glycyl-2-aminoethane
  参考文献：
  名称：

  Synthesis and evaluation of ursolic acid derivatives as potent cytotoxic agents

  摘要：

  Structural modification was performed at the C-3 and C-28 positions of ursolic acid (UA). Ten UA derivatives with distinct electrical property were synthesized. They could be divided into two groups according to their charge under physiological conditions: (1) Group I negatively charged and (2) Group II positively charged. The anti-proliferative capability of the derivatives was evaluated against HepG2, AGS, HT-29 and PC-3 cells by the MTT assay. Flow cytometry and Annexin V/PI dual staining assay were carried out to explore the antitumor mechanism. The results showed the cytotoxic capacity of the compounds was: Group I < UA < Group II. The UA derivatives in Group II exhibited potent cytotoxicity and the enhancement of the lipophilicity could further strengthen the cytotoxicity. Triggering apoptosis and causing cell cycle arrest contributed to the anticancer mechanism. The UA derivative UA-7 had the therapeutic potential in the treatment of gastric carcinoma since it showed potent cytotoxicity, reasonable oil/water partition, enhanced water solubility, and the ability to induce the apoptosis of AGS cells. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.02.009

文献信息

• Synthesis and evaluation of ursolic acid derivatives as potent cytotoxic agents
  作者：Kai-Kai Bai、Zhou Yu、Fen-Ling Chen、Feng Li、Wei-Yun Li、Yang-Hao Guo

  DOI：10.1016/j.bmcl.2012.02.009

  日期：2012.4

  Structural modification was performed at the C-3 and C-28 positions of ursolic acid (UA). Ten UA derivatives with distinct electrical property were synthesized. They could be divided into two groups according to their charge under physiological conditions: (1) Group I negatively charged and (2) Group II positively charged. The anti-proliferative capability of the derivatives was evaluated against HepG2, AGS, HT-29 and PC-3 cells by the MTT assay. Flow cytometry and Annexin V/PI dual staining assay were carried out to explore the antitumor mechanism. The results showed the cytotoxic capacity of the compounds was: Group I < UA < Group II. The UA derivatives in Group II exhibited potent cytotoxicity and the enhancement of the lipophilicity could further strengthen the cytotoxicity. Triggering apoptosis and causing cell cycle arrest contributed to the anticancer mechanism. The UA derivative UA-7 had the therapeutic potential in the treatment of gastric carcinoma since it showed potent cytotoxicity, reasonable oil/water partition, enhanced water solubility, and the ability to induce the apoptosis of AGS cells. (C) 2012 Elsevier Ltd. All rights reserved.