对氟苯甲醇 | 59-56-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 对氟苯甲醇
• 中文别名: Α-D-葡糖-1-磷酸；葡萄糖-1-磷酸
• 英文名称: α-D-glucopyranosyl-1-phosphate
• 英文别名: glucose-1-phosphate；α-D-glucose-1-phosphate；α-glucose 1-phosphate；α-Glc-1P；α-D-glucopyranosyl phosphate；D-glucose-1-phosphate；Glc-1-P；alpha-D-glucose-1-phosphate；[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] dihydrogen phosphate
• CAS: 59-56-3
• 化学式: C₆H₁₃O₉P
• 分子量: 260.138
• InChiKey: HXXFSFRBOHSIMQ-VFUOTHLCSA-N

物化性质

• 沸点：
  603.0±65.0 °C(Predicted)
• 密度：
  1.90±0.1 g/cm3(Predicted)
• 溶解度：
  Soluble (water), slightly soluble (ethanol)
• 物理描述：
  Solid
• 碰撞截面：
  158 Ų [M+Na]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]

计算性质

• 辛醇/水分配系数(LogP)：
  -3.8
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  157
• 氢给体数：
  6
• 氢受体数：
  9

安全信息

• 危险等级：
  8
• 危险品运输编号：
  UN 1759
• 包装等级：
  III
• 安全说明：
  S24/25

反应信息

• 作为反应物：
  描述：

  对氟苯甲醇 以 水 为溶剂， 生成 Maltohexaose
  参考文献：
  名称：

  Determination of kinetic parameters for maltotriose and higher malto-oligosaccharides in the reactions catalyzed by α-d-glucan phosphorylase from potato

  摘要：

  For kinetic studies on its synthetic and phosphorolytic reactions, alpha-D-glucan phosphorylase form potatoes was purified chromatographically until free of D-enzyme. Purified maltotriose (G3) is a poor primer in the phosphorylase-catalyzed synthetic reaction, showing an anomalous time course and making previous attempts to determine its kinetic parameters unsuccessful. In the present work the true rate of the G3-primed reaction was obtained from linear plots obtained by incorporating a sufficient quantity of beta-amylase in the digest to eliminate the more rapidly reacting G4 formed from the G3. A K(m) value of 9.4 +/- 0.8 mM for G3 was calculated from the data by a nonlinear least-squares method. Kinetic parameters for a series of higher malto-oligosaccharides (G4-G8) were also determined in both the synthetic and the phosphorolytic directions. A large change in the values of K(m) and V/e was seen on going from G3 to G4 for the synthetic reaction, and from G4 to G5 for the phosphorolytic. For the higher saccharides the V/e values do not vary strongly with increasing d.p., while the K(m) values tend to decrease, as has seen in the reactions of other plant phosphorylases.

  DOI：

  10.1016/0008-6215(91)84131-w
• 作为产物：
  描述：

  dibezylphosphoryl 2,3,4,6-tetra-O-benzyl-α-D-glucopyranoside 在 钯 氢气 作用下， 以 四氢呋喃 、 乙酸乙酯 为溶剂， 反应 0.5h， 以69%的产率得到对氟苯甲醇
  参考文献：
  名称：

  Schmidt, Richard R.; Stumpp, Michael, Liebigs Annalen der Chemie, 1984, # 4, p. 680 - 691

  摘要：

  DOI：

文献信息

• Synthesis of Galactose-Terminated Oligosaccharides by Use of Galactosyltransferase
  作者：Joachim Thiem、Torsten Wiemann

  DOI：10.1055/s-1992-34174

  日期：——

  Galactosyltransferase catalyzes the galactosylation of oligosaccharides terminated by glucose and by 2-acetamido-2-deoxy glucopyranose, respectively. Variations concerning the acceptor substrate as well as the donor substrate are described.

  半乳糖基转移酶分别催化以葡萄糖和2-乙酰胺基-2-脱氧吡喃葡萄糖为末端的多糖的半乳糖基化反应。本文描述了关于受体底物和供体底物的变化。
• CHEMOENZYMATIC SYNTHESIS OF HEPARIN AND HEPARAN SULFATE ANALOGS
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20140235575A1

  公开（公告）日：2014-08-21

  The present invention provides a one-pot multi-enzyme method for preparing UDP-sugars from simple sugar starting materials. The invention also provides a one-pot multi-enzyme method for preparing oligosaccharides from simple sugar starting materials.

  本发明提供了一种一锅多酶法，用于从简单糖起始材料制备UDP糖。该发明还提供了一种一锅多酶法，用于从简单糖起始材料制备寡糖。
• [EN] N-GLYCOSYLATION OF PEPTIDES AND PROTEINS<br/>[FR] N-GLYCOSYLATION DE PEPTIDES ET DE PROTÉINES
  申请人：ISIS INNOVATION

  公开号：WO2015056011A1

  公开（公告）日：2015-04-23

  A process for the production of a glycoconjugate by N-glycosylation of a protein or peptide comprising the sequence D/E-X-N-X-S/T, wherein each X is the same or different and is any natural amino acid other than proline, wherein the process comprises reacting the protein or peptide with a polyisoprenyl pyrophosphate of formula (I), or a salt thereof, in the presence of PglB: (I) to produce the glycoconjugate comprising the protein or peptide having a saccharide [SI] linked to the asparagine in the sequence D/E-X-N-X-S/T. Polyisoprenylpyrophosphates used as substrates in the biocatalytic process are also provided, as well as certain glycoconjugates.

  一种通过蛋白质或肽的N-糖基化制备糖蛋白的方法，所述蛋白质或肽包括序列D/E-X-N-X-S/T，其中每个X相同或不同，是任何天然氨基酸，但不包括脯氨酸，该方法包括将蛋白质或肽与式(I)的聚异戊二烯基焦磷酸盐或其盐在PglB的存在下反应，以产生包含与序列D/E-X-N-X-S/T中的天冬氨酸连接的糖蛋白。还提供了作为生物催化过程中底物使用的聚异戊二烯基焦磷酸盐，以及某些糖蛋白。
• Active-site engineering of nucleotidylyltransferases and general enzymatic methods for the synthesis of natural and "unnatural" UDP- and TDP-nucleotide sugars
  申请人：——

  公开号：US20030055235A1

  公开（公告）日：2003-03-20

  The present invention provides mutant nucleotidylyl-transferases, such as E p , having altered substrate specificity; methods for their production; and methods of producing nucleotide sugars, which utilize these nucleotidylyl-transferases. The present invention also provides methods of synthesizing desired nucleotide sugars using natural and/or modified Ep or other nucleotidyltransferases; and nucleotide sugars sythesized by the present methods. The present invention further provides new glycosyl phosphates, and methods for making them.

  本发明提供了一种突变型核苷酸转移酶，如E p ，具有改变的底物特异性；其生产方法；以及利用这些核苷酸转移酶生产核苷酸糖的方法。本发明还提供了使用天然和/或修饰的Ep或其他核苷酸转移酶合成所需的核苷酸糖的方法；以及通过本发明方法合成的核苷酸糖。本发明进一步提供了新的糖基磷酸酯，及其制造方法。
• Novel substrates for the automated and manual assay of endo -1,4-β-xylanase
  作者：David Mangan、Claudio Cornaggia、Agnija Liadova、Niall McCormack、Ruth Ivory、Vincent A. McKie、Aaron Ormerod、Barry V. McCleary

  DOI：10.1016/j.carres.2017.02.009

  日期：2017.6

  reproducible, automatable assay for this enzyme that is based on the use of a chemically defined substrate has not been described to date. Reported herein is a new enzyme coupled assay procedure, termed the XylX6 assay, that employs a novel substrate, namely 4,6-O-(3-ketobutylidene)-4-nitrophenyl-β-45-O-glucosyl-xylopentaoside. The development of the substrate and associated assay is discussed here and

  1，4-β-木聚糖内切酶（EC 3.2.1.8）被广泛应用于动物饲料，酿造，烘焙，生物燃料，洗涤剂和纸浆（纸）等行业。尽管其重要性，迄今为止尚未描述基于使用化学确定的底物对该酶进行快速，可靠，可再现，可自动化的测定。本文报道了一种新的酶偶联测定方法，称为XylX6测定法，其采用了新型底物，即4，6-O-（3-酮丁烯）-4-硝基苯基-β-45-O-葡糖基-木糖基opentaoside。本文讨论了底物和相关测定法的发展，并彻底研究了XylX6测定法与传统还原糖测定法获得的活性值之间的关系及其特异性和可重复性。