2,4-二氯-6-[(3,5-二氯-2-羟基-苯基)甲基]苯酚 | 1940-43-8

• 物质功能分类: 有机原料 - 醇、酚、酚醇类化合物及衍生物 - 酚及其卤化、磺化、硝化或亚硝化衍生物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,4-二氯-6-[(3,5-二氯-2-羟基-苯基)甲基]苯酚
• 英文名称: 2,2'-methylenebis(4,6-dichlorophenol)
• 英文别名: bis-(2-hydroxy-3,5-dichlorophenyl)-methane；bis(3,5-dichloro-2-hydroxyphenyl)-methane；4,6,4',6'-tetrachloro-2,2'-methanediyl-di-phenol；4,6,4',6'-Tetrachlor-2,2'-methandiyl-di-phenol；Bis-(3.5-dichlor-2-hydroxy-phenyl)-methan；3,3',5,5'-Tetrachlor-2,2'-dihydroxy-diphenylmethan；Tetrachlorophene；2,4-dichloro-6-[(3,5-dichloro-2-hydroxyphenyl)methyl]phenol
• CAS: 1940-43-8
• 化学式: C₁₃H₈Cl₄O₂
• 分子量: 338.017
• InChiKey: PKKDWPSOOQBWFB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,4-二氯-6-[(3,5-二氯-2-羟基-苯基)甲基]苯酚 生成 2,4,18,20-tetrachloro-6,7,9,10,12,13,15,16-octahydro-22H-dibenzo[n,q][1,4,7,10,13]pentaoxacyclo-octadecin
  参考文献：
  名称：

  Polyether derivatives

  摘要：

  提供具有以下结构式的聚醚衍生物：其中R.sup.1、R.sup.2、R.sup.5和R.sup.6相同或不同，可以是氢、卤素、硝基、低烷基或氰基；R.sup.3和R.sup.4相同或不同，可以是氢、卤素或一起表示.dbd.O；n为1至5。这些化合物可用作球虫防治剂和抗炎剂。

  公开号：

  US04196250A1
• 作为产物：
  描述：

  亚甲基二苯酚 在 磺酰氯 、 溶剂黄146 作用下， 以9%的产率得到双氯酚
  参考文献：
  名称：

  Synthesis and antimicrobial activities of halogenated bis(hydroxyphenyl)methanes

  摘要：

  A series of halophenols was prepared by the reaction of bis(hydroxyphenyl) methanes with effective halogenating agents such as bromine and sulfuryl chloride. One of these compounds, a biologically active halophenol-2,2',3,3'-tetrabromo-4,4',5,5'-tetrahydroxydiphenylmethane (1)-frequently isolated from red algae, was synthesized for the first time. Other halophenols included several novel compounds, together with known derivatives that were synthesized from the phenolic intermediates, bis(3,4-dihydroxyphenyl) methane (5) and bis(2-hydroxyphenyl) methane (14). All of the synthesized compounds were tested for antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. The preliminary structure-activity relationship was investigated in order to determine the essential structural requirements for their antimicrobial activity. Of all these halophenols, 2,2',3,3',6-pentabromo-4,4',5,5'-tetrahydroxydiphenylmethane (8) was found to be the most active against Candida albicans, Aspergillus fumigatus, Trichophyton rubrum, and Trichophyton mentagrophytes while 3,3',5,5'-tetrachloro-2,2'-dihydroxydiphenylmethane (18) exerted a powerful antibacterial effect against Staphylococcus aureus, Bacillus subtilis, Micrococcus luteus, Proteus vulgaris, and Salmonella typhimurium. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.11.089

文献信息

• MODIFIER FOR AROMATIC POLYESTER AND AROMATIC POLYESTER RESIN COMPOSITION COMPRISING THE SAME
  申请人：TABATA Masayoshi

  公开号：US20110224343A1

  公开（公告）日：2011-09-15

  The present invention provides a modifier for aromatic polyesters which enhances the melt fluidity of aromatic polyesters without a significant decrease in the heat resistance of the aromatic polyesters, and an aromatic polyester resin composition including the modifier for aromatic polyesters. The present invention relates to a modifier for aromatic polyesters comprising polyhydric phenol residues and residues of aromatic polycarboxylic acid, acid halide or acid anhydride thereof, and the modifier comprises a material having a structure composed of a first residue selected from the group consisting of divalent residues represented by Formula (I): —Ar—W 1 x —Ar— and by Formula (II): —Ar—, the first residues being bonded to two identical or different second residues selected from the group consisting of monovalent residues represented by Formula (III): and monovalent residues represented by Formula (IV): —O—C(O)—R 7 —.

  本发明提供了一种用于芳香族聚酯的改性剂，可以增强芳香族聚酯的熔融流动性，而不明显降低芳香族聚酯的耐热性，以及包括该改性剂的芳香族聚酯树脂组合物。本发明涉及一种用于芳香族聚酯的改性剂，包括多羟基酚残基和芳香族多羧酸、酸卤或其酸酐残基，该改性剂包括具有以下结构的材料：第一残基，选择自由式(I)所代表的二价残基：—Ar—W1x—Ar—和自由式(II)所代表的：—Ar—，第一残基与选择自由式(III)所代表的单价残基：和自由式(IV)所代表的单价残基：—O—C(O)—R7—的两个相同或不同的第二残基结合。
• METHODS OF REDUCING MICROBIAL CONTAMINATION
  申请人：Scholz Matthew T.

  公开号：US20090226541A1

  公开（公告）日：2009-09-10

  Methods of delaying the onset of an infection or preventing an infection caused by a microbial organism in an internal cavity of a subject are provided. Methods of killing or inactivating microorganisms in at least a portion of the urethra of a subject are provided.

  提供了延迟微生物体在主体内部腔引起感染或预防感染的方法。提供了在主体的尿道至少部分区域内杀死或灭活微生物的方法。
• N,N'-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION
  申请人：Aktas Bertal Huseyin

  公开号：US20120115915A1

  公开（公告）日：2012-05-10

  Compositions and methods for inhibiting translation initiation are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using N,N′-diarylureas and/or N,N′-diarylthiourea compounds are described.

  本文提供了抑制翻译起始的组合物和方法。描述了使用N，N'-二芳基脲和/或N，N'-二芳基硫脲化合物治疗（1）细胞增生性疾病，（2）非增生性退行性疾病，（3）病毒感染和/或（4）与病毒感染相关的疾病的组合物、方法和试剂盒。
• Mild antimicrobial liquid cleansing formulations
  申请人：UNILEVER PLC

  公开号：EP1502584A1

  公开（公告）日：2005-02-02

  A skin cleansing composition comprising: (1) 1% to 99% by weight of a surfactant system comprising: (a) 1% to 30% by wt. of at least one anionic surfactant; and (b) 0.5% to 15% by wt. of an amphoteric surfactant; (2) 0.5% to 9% by wt. hydroxy carboxylic acid; (3) 0.001% to 5% by weight of an antibacterial agent; and (4) 1% to 99% by weight water.

  一种皮肤清洁组合物，包括 (1) 1%至 99%（按重量计）的表面活性剂体系，包括 (a) 1%至 30%（重量百分比）的至少一种阴离子表面活性剂；以及 (b) 0.5%至 15%（重量百分比）的两性表面活性剂； (2) 0.5%至 9%（重量百分比）羟基羧酸； (3) 0.001%至 5%（重量百分比）的抗菌剂； 和 (4) 1%至 99%（重量百分比）的水。
• AROMATIC POLYESTER
  申请人：Muroran Institute of Technology

  公开号：EP2479203A1

  公开（公告）日：2012-07-25

  The present invention provides an aromatic polyester which is substantially free from the occurrence of coloration and retains significantly high transparency even after being thermally processed at high temperature and which has high flowability. The aromatic polyester contains a polyhydric phenol residue and a residue of any one of aromatic polycarboxylic acid, halide thereof, and anhydride thereof, and terminals of the aromatic polyester have a structure represented by the formula -C(O)-R. The aromatic polyester has an end-capping rate of 90% or higher and a weight average molecular weight (Mw) ranging from 3,000 to 1,000,000.

  本发明提供了一种芳香族聚酯，该聚酯基本上不会发生着色，即使在高温热加工后仍能保持明显的高透明度，并且具有高流动性。芳香族聚酯含有多羟基苯酚残留物和芳香族多羧酸、其卤化物和其酸酐中任意一种的残留物，芳香族聚酯的端基具有式 -C(O)-R 所代表的结构。芳香族聚酯的端盖率为 90% 或更高，重量平均分子量（Mw）为 3,000 至 1,000,000 之间。