异维生素D3 | 42607-12-5

• 物质功能分类: 分析化学 - 标准品 - 药典标准品和杂质标准品
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 异维生素D3
• 中文别名: 维生素D3杂质08
• 英文名称: all-trans-9,10-seco-1(10),5,7-cholestatrien-3β-ol
• 英文别名: isovitamin D₃；(5E)-Isovitamin D3/(5E)-isocholecalciferol；(1S,5E)-5-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylcyclohex-3-en-1-ol
• CAS: 42607-12-5
• 化学式: C₂₇H₄₄O
• 分子量: 384.646
• InChiKey: LMBGVVOJTGHJNP-FVUVGDFOSA-N

物化性质

• 溶解度：
  丙酮（微溶）、氯仿（微溶）、甲醇（微溶）

计算性质

• 辛醇/水分配系数(LogP)：
  7.9
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  维生素 D3 以 二甲基亚砜 为溶剂， 反应 1.0h， 以42%的产率得到异速甾醇3
  参考文献：
  名称：

  Jin, Xiaoling; Yang, Xinping; Yang, Li, Journal of Chemical Research - Part S, 2003, # 11, p. 691 - 693

  摘要：

  DOI：

文献信息

• Steroid kit and foamable composition and uses thereof
  申请人：Friedman Doron

  公开号：US20060018937A1

  公开（公告）日：2006-01-26

  A composition and therapeutic kit including an aerosol packaging assembly including a container accommodating a pressurized product and an outlet capable of releasing a foamable composition, including a steroid as a foam. The pressurized product includes a foamable composition including: a container accommodating a pressurized product; and an outlet capable of releasing the pressurized product as a foam; wherein the pressurized product comprises a foamable composition including: i. a steroid; ii. at least one organic carrier selected from the group consisting of a hydrophobic organic carrier, a polar solvent, an emollient and mixtures thereof, at a concentration of about 2% to about 50% by weight; iii. a surface-active agent; iv. about 0.01% to about 5% by weight of at least one polymeric additive selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent; v. water; and vi. liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition. The composition further may include a therapeutically active foam adjuvant, selected from the group consisting of a fatty alcohol, a fatty acid, a hydroxyl fatty acid; and mixtures thereof.

  一种组合物和治疗包，包括一个气雾剂包装组件，其中包括一个容纳加压产品的容器和一个能够以泡沫形式释放可发泡组合物（包括类固醇）的出口。加压产品包括可发泡组合物，其中可发泡组合物包括：容纳加压产品的容器；以及能够将加压产品作为泡沫释放的出口；其中加压产品包括可发泡组合物，其中可发泡组合物包括： i. 类固醇； ii. 至少一种有机载体，选自由疏水性有机载体、极性溶剂、润肤剂及其混合物组成的组，浓度为约 2%至约 50%（按重量计）； iii.约 0.01%至约 5%（按重量计）的至少一种聚合物添加剂，该聚合物添加剂选 自生物粘合剂、胶凝剂、成膜剂和相变剂组成的组； v. 水；以及 vi. 液化或压缩气体推进剂，其浓度约为总组合物的 3%至约 25%（按重量计）。该组合物还可包括一种治疗活性泡沫佐剂，选自脂肪醇、脂肪酸、羟基脂肪酸及其混合物组成的组。
• Oleaginous pharmaceutical and cosmetic foam
  申请人：Tamarkin Dov

  公开号：US20070292461A1

  公开（公告）日：2007-12-20

  The invention relates to stable pharmaceutical or cosmetic foam compositions containing certain active agents, having unique therapeutic properties and methods of treatment using such compositions. The foamable composition includes at least one solvent comprising polyethylene glycol (PEG) or PEG derivative and mixtures thereof, or comprising propylene glycol, wherein the solvent is present at a concentration of about 70% to about 96.5% by weight of the total composition, at least a non-ionic surface-active agent at a concentration of about 0.1% to less than about 10% by weight of the total composition.
• SILICONE IN GLYCOL PHARMACEUTICAL AND COSMETIC COMPOSITIONS WITH ACCOMMODATING AGENT
  申请人：TAMARKIN Dov

  公开号：US20080292560A1

  公开（公告）日：2008-11-27

  A carrier, composition or foam formulation comprising; a silicone; about 25% to about 98% of a solvent selected from the group consisting of (1) a propylene glycol or derivative and (2) a polyethylene glycol (PEG) or derivative or mixtures thereof; 0% to about 48% of at least one secondary solvent; and an Accommodating Agent or Complex; and methods of treatment. A hygroscopic silicone in glycol containing composition includes at least one hygroscopic substance at a concentration sufficient to provide an Aw value of at least 0.9 and a therapeutic agent.
• HYDROPHILIC, NON-AQUEOUS PHARMACEUTICAL CARRIERS AND COMPOSITIONS AND USES
  申请人：Tamarkin Dov

  公开号：US20080299220A1

  公开（公告）日：2008-12-04

  A waterless composition suitable for delivery of an active agent to a body surface or cavity includes a vehicle having about 70% to about 99% by weight of a hydrophilic polar solvent, said hydrophilic solvent selected from the group consisting of (i) a mixture of two or more different polyethylene glycols (PEGs), wherein at least one PEG is a high molecular weight PEG having a melting point greater than 25° C.; and (ii) propylene glycol (PG); about 0% to about 10% of at least one surface active agent; about 0% to about 5% of a polymeric agent; about 0% to about 30% of a secondary hydrophilic solvent; and about 0% to about 5% of a silicone oil; and about 3% to about 25% hydrophobic propellant. The composition is otherwise substantially free of a hydrophobic solvent and includes at least one of a surface active agent and a polymeric agent. The vehicle and the propellant are sufficiently miscible that the components may be homogeneously distributed with mild shaking.
• US8486374B2
  申请人：——

  公开号：US8486374B2

  公开（公告）日：2013-07-16