A new eudesmane-type sesquiterpene, zedoarofuran, and six new guaiane- or seco-guaiane-type sesquiterpenes, 4-epicurcumenol, neocurcumenol, gajutsulactones A and B, and zedoarolides A and B, were isolated from aqueous acetone extract of Zedoariae Rhizoma together with 36 known sesquiterpenes and two diarylheptanoids. Their stereostructures were elucidated on the basis of chemical and physicochemical evidence. The effects of isolated components on nitric oxide production in lipopolysaccharide-activated mouse peritoneal macrophages were examined and 16 sesquiterpenes including gajutsulactones A and B, and bis(4-hydroxycinamoyl)methane were found to show inhibitory activity.
从莪术的
丙酮水提取物中分离出一种新的
桉烷型
倍半萜烯,即莪术
呋喃,以及六种新的
愈创木烷型或断愈烷型
倍半萜烯,即4-表姜黄烯醇、新姜黄烯醇、gajutsulactones A和B以及zedoarolides A和B。 36 种已知的
倍半萜烯和两种二芳基
庚烷类化合物。根据
化学和物理
化学证据阐明了它们的立体结构。研究了分离的成分对脂
多糖激活的小鼠腹腔巨噬细胞中
一氧化氮产生的影响,发现包括 Gajutsulactones A 和 B 在内的 16 种
倍半萜烯以及双(
4-羟基肉桂酰基)
甲烷表现出抑制活性。