丁二酸正十八酯 | 5693-14-1

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 丁二酸正十八酯
• 英文名称: 2-Stearylbernsteinsaeure
• 英文别名: octadecyl-succinic acid；Octadecyl-bernsteinsaeure；monoester of octadecylsuccinic acid；2-octadecyl-succinic acid；Octadecylsuccinic acid；2-octadecylbutanedioic acid
• CAS: 5693-14-1
• 化学式: C₂₂H₄₂O₄
• 分子量: 370.573
• InChiKey: ZPJDFKVKOFGAFV-UHFFFAOYSA-N

物化性质

• 熔点：
  99-101°C
• 沸点：
  480.6±18.0 °C(Predicted)
• 密度：
  0.971±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.8
• 重原子数：
  26
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 安全说明：
  S22,S24/25

反应信息

• 作为反应物：
  描述：

  C20-O-trityl-prostratin-ol 、 丁二酸正十八酯 在 吡啶 、 4-二甲氨基吡啶 作用下， 以31.31 %的产率得到2-[2-[[(1R,2S,6R,10S,11R,13S,15R)-1,6-dihydroxy-4,12,12,15-tetramethyl-5-oxo-8-(trityloxymethyl)-13-tetracyclo[8.5.0.02,6.011,13]pentadeca-3,8-dienyl]oxy]-2-oxoethyl]icosanoic acid
  参考文献：
  名称：

  [EN] DITERPENOID COMPOUNDS THAT ACT ON PROTEIN KINASE C (PKC)
  [FR] COMPOSÉS DITERPÉNOÏDES AGISSANT SUR LA PROTÉINE KINASE C (PKC)

  摘要：

  This present disclosure relates to a method of stimulating an immune response using compounds that activate protein kinase C (PKC), including for treatment of a cancer, a precancerous lesion, a benign tumor, or a wound.

  公开号：

  WO2022204327A1
• 作为产物：
  描述：

  十八碳烯 在 氢氧化钾 、 二叔丁基过氧化物 作用下， 生成 丁二酸正十八酯
  参考文献：
  名称：

  Ogibin,Yu.N. et al., Journal of Organic Chemistry USSR (English Translation), 1970, vol. 6, p. 1412 - 1415

  摘要：

  DOI：

文献信息

• Hydroxylamine esters as polymerization initiators
  申请人：——

  公开号：US20030216494A1

  公开（公告）日：2003-11-20

  The invention relates to novel cyclic and open-chain hydroxylamine esters and polymerizable compositions comprising these hydroxylamine esters and an ethylenically unsaturated monomer or oligomer. The invention also relates to use as polymerization initiators and to the use of known hydroxylamine esters selected from the group consisting of HALS compounds and the novel hydroxylamine esters for the controlled degradation of polypropylene and for achieving a controlled increase in the molecular weight of polyethylene.

  该发明涉及新型环状和开链羟胺酯以及包括这些羟胺酯和乙烯基不饱和单体或寡聚物的可聚合组合物。该发明还涉及用作聚合引发剂以及用于控制聚丙烯降解和实现聚乙烯分子量控制增加的已知羟胺酯，所述羟胺酯来自HALS化合物和新颖羟胺酯的组合。
• Method for making carboxylic acids
  申请人：Bonnet Didier

  公开号：US20060094900A1

  公开（公告）日：2006-05-04

  The present invention relates to a process for producing carboxylic acids. It relates more particularly to a process for producing carboxylic acids by oxidation of a hydrocarbon with oxygen or a gas containing oxygen, and even more particularly to the oxidation of cyclohexane to adipic acid. The invention relates to a process for producing carboxylic acids by oxidation with oxygen or a gas containing oxygen of a cycloaliphatic hydrocarbon in the presence of an oxidation catalyst and of a monocarboxylic oxidation solvent that is lipophilic in nature, comprising a step of extraction of the dicarboxylic acids formed in the oxidation step, consisting in carrying out, in liquid phase, an extraction of the diacids using water.

  本发明涉及一种生产羧酸的方法。它更具体地涉及一种通过将烃与氧气或含氧气体氧化来生产羧酸的方法，更具体地涉及环己烷氧化为己二酸的方法。该发明涉及一种通过在氧化催化剂和亲脂性单羧氧化溶剂存在下对环脂环烃烃类化合物氧化而产生羧酸的方法，包括在液相中提取在氧化步骤中形成的二羧酸的步骤，其中通过使用水进行二酸的提取。
• Production of Carboxylic Acids
  申请人：Bonnet Didier

  公开号：US20090306425A1

  公开（公告）日：2009-12-10

  A process for the production of carboxylic acids by oxidation of a hydrocarbon by oxygen or a gas containing oxygen and notably to the oxidation of cyclohexane to give adipic acid; the subject process entails a stage of oxidation of the hydrocarbon and at least one stage for extracting the dicarboxylic acids formed from the reaction medium and optionally recycling the unconverted hydrocarbon with oxidation by-products, such as alcohols and ketones, and which also includes a stage of conversion, removal or extraction of the α,ω-hydroxycarboxylic compounds formed during the oxidation stage and converting these compounds into diacids.

  一种通过氧气或含氧气体氧化烃制备羧酸的工艺，特别是氧化环己烷以得到己二酸；所述工艺包括烃的氧化阶段和至少一个用于从反应介质中提取形成的二羧酸的阶段，可选择性地将未转化的烃与氧化副产物（如醇和酮）回收，并且还包括将在氧化阶段形成的α，ω-羟基羧酸化合物转化、去除或提取的阶段，并将这些化合物转化为二酸。
• Method for oxidising hydrocarbons
  申请人：——

  公开号：US20040147777A1

  公开（公告）日：2004-07-29

  The present invention relates to a process for the oxidation of hydrocarbons, in particular of branched or unbranched saturated aliphatic hydrocarbons or of cycloaliphatic or alkylaromatic hydrocarbons, to alcohol, ketone and/or acid or polyacid compounds. It relates more particularly to the oxidation, by an oxidizing agent comprising molecular oxygen, of cyclohexane to cyclohexanonol, cyclohexanone and/or adipic acid. The oxidation is carried out in the presence of a catalytic system comprising a catalyst based on at least one metal compound and a cocatalyst comprising an imide functional group, such as N-bromosuccinimide, N-bromomaleimide, N-bromohexahydrophthalimide, N,N′-dibromocyclohexane-tetracarboximide, N-bromophthalimide, N-bromotrimellitimide or N,N′-dibromopyromellitimide.

  本发明涉及一种氧化烃的过程，特别是支链或直链饱和脂肪烃或环脂肪烃或烷基芳烃氧化为醇、酮和/或酸或多酸化合物。它更具体地涉及使用含有分子氧的氧化剂对环己烷氧化为环己烷醇、环己酮和/或己二酸的氧化反应。氧化反应在存在基于至少一种金属化合物的催化剂和包含亚胺官能团的协同催化剂的催化系统下进行，例如N-溴代琥珀酰亚胺、N-溴代马来酰亚胺、N-溴代六氢邻苯二酰亚胺、N,N'-二溴环己烷四羧亚胺、N-溴邻苯二酰亚胺、N-溴三苯酰亚胺或N,N'-二溴吡罗酰亚胺。
• Novel antibacterial agents
  申请人：Christensen G. Burton

  公开号：US20070134729A1

  公开（公告）日：2007-06-14

  This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands has a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.

  本发明涉及一种新型多结合化合物（药剂），其为抗菌剂。该发明的多结合化合物由2-10个配体通过连接剂或连接剂共价连接而成，其中每个单价（即未连接的）配体具有与细胞壁生物合成和代谢中的酶、合成细菌细胞壁和/或细菌细胞表面的前体有结合能力，从而干扰细胞壁的合成和/或代谢。特别地，本发明的多结合化合物由2-10个配体通过连接剂或连接剂共价连接而成，其中每个配体具有能够结合青霉素结合蛋白、横向肽酶酶、横向肽酶酶底物、β-内酰胺酶、青霉素酶、头孢菌素酶、横向转移酶酶或横向转移酶酶底物的配体结构域。优选地，配体选自β-内酰胺类或糖肽类抗菌剂。