METHYL METHACRYLATE, AND IN GENERAL THE METHACRYLIC ESTERS, POLYMERIZE MUCH LESS READILY THAN THE CORRESPONDING ORDINARY ACRYLATES. NONE THE LESS, THEY ARE STABILIZED BY ADDING HYDROQUINONE OR PYROGALLOL, PARTICULARLY IN THE PRESENCE OF METALLIC COPPER. /METHACRYLATES/
SMALL QUANTITIES OF METHACRYLATES MAY READILY BE METABOLIZED BY SAPONIFICATION INTO THE ALCOHOL AND METHACRYLIC ACID. THE LATTER MAY FORM AN ACETYL-COENZYME A DERIVATIVE, WHICH THEN ENTERS THE NORMAL LIPID METABOLISM. /METHACRYLIC ESTERS/
来源:Hazardous Substances Data Bank (HSDB)
毒理性
副作用
皮肤致敏剂 - 一种可以诱导皮肤产生过敏反应的制剂。
Skin Sensitizer - An agent that can induce an allergic reaction in the skin.
来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
BIOLOGICALLY, METHACRYLATES RESEMBLE ACRYLATES, EXCEPT FOR LOWER REACTIVITY & THUS DECR TOXICITY. THIS IS PROBABLY DUE TO STERIC HINDRANCE BY ITS METHYL GROUP & IN TURN DECR RATES OF MEMBRANE TRANSPORT & SYSTEMIC TRANSLOCATION. /METHACRYLIC ESTERS/
Seven patients were occupationally sensitized to dental composite resin products (DCR): 6 dental nurses and 1 dentist. All had a positive patch test to their DCR. Two independent types of allergy were seen: (a) aromatic epoxy acrylate and/or (b) aliphatic acrylates. Four out of 5 patients reacted to BIS-GMA, the most widely used aromatic epoxy acrylate in DCR, but not the dentist. She and 2 dental nurses were allergic to aliphatic acrylates, including triethylene glycol dimethacrylate (TREGDMA) and triethylene diglycol diacrylate (TREGDA). Four patients were allergic to epoxy resin (ER) (containing mainly MW 340), possibly an impurity in some DCR. Two patients were also allergic to methyl methacrylate (MMA): the dentist had been exposed to MMA but the nurses exposure was uncertain. One patient was also allergic to rubber gloves, 2 to rubber chemicals but not their gloves, and 5 to disinfectants used. Diagnosis was delayed as long as 13 yr in spite of previous patch testing. Dermatologists need to use the patients own DCR and the methacrylate series for patch testing. Dental personnel need to know about the risks of DCR, and use no touch techniques and protective gloves.
Epoxy and acrylic resins have numerous industrial applications but are also widely used in the household environment. These compounds are presently one of the most important sources of occupational contact dermatitis. Contact sensitization to epoxy resins is usually caused by the resin itself but hardeners or other additives, such as reactive diluents, plasticizers, fillers and pigments, can occasionally be responsible. Since completely cured epoxy resins are not sensitizers, epoxy resin sensitization is always due to the presence, in the final polymer, of uncured allergenic low molecular weight oligomers. Acrylates are now considered the fourth most common cause of contact sensitization due to resins. Unpolymerized monomers of acrylic compounds are known to be responsible for the contact allergy. Accelerators, inhibitors and catalysts, which are usually added to the acrylates to promote the polymerization process, can also sensitize. Both allergic and irritant contact dermatitis may be caused by exposure to epoxy or acrylic resins and their additives. Contact urticaria, allergic or irritant airborne contact dermatitis caused by volatile compounds, onychia and paronychia can also occur. From January of 1984 to May of 1992 we detected 39 cases of occupational allergic contact dermatitis to epoxy resin system substances and 11 cases of occupational contact sensitization to acrylic compounds. In our experience, the electronics industry as well as paint and glue related activities were the most important sources of epoxy sensitization. Dental materials and anaerobic sealants were found to be the most frequent acrylate sensitizers. /Epoxy & acrylic resins/
TWENTY-ONE DIFFERENT ACRYLATE & METHACRYLATE COMPOUNDS, INCLUDING TRIETHYLENE GLYCOL DIMETHACRYLATE, WERE SCANNED FOR THEIR ABILITY TO INDUCE CONTACT SENSITIVITY, USING 5 DIFFERENT SENSITIZATION PROTOCOLS. CONTACT REACTIONS OF VARYING INTENSITIES WERE PRODUCED TO ALL THE MONO-, DI-, AND TRIACRYLATES TESTED. METHACRYLATES DID NOT SENSITIZE GUINEA PIGS.
Propagation and Termination Kinetics of Cross-Linking Photopolymerizations Studied Using Electron Paramagnetic Resonance Spectroscopy in Conjunction with Near IR Spectroscopy
摘要：
The use of electron paramagnetic resonance (EPR) in conjunction with Fourier transform near infrared (FT-NIR) spectroscopy to address the complexities associated with the accurate measurement and evaluation of cross-linking polymerization kinetics over the entire conversion range is explored. Experimental protocols are developed providing a more complete picture of the mechanistic and kinetic underpinnings of these radical polymerizations, accessing information that is otherwise unavailable to these techniques individually. The kinetics of two multimethaerylate polymerization systems, one forming a rubbery and the other a glassy polymer network, are compared and contrasted revealing numerous differences in their attributes as characterized by this experimental combination. Steady-state and unsteady-state radical concentration profiles, propagating radical environments during polymerization, and persistent radical populations are explored and utilized to evaluate the underlying propagation and termination kinetics. Subsequently, kinetic parameters obtained with EPR and EPR/FT-NIR are compared with those obtained independently from FT-NIR, enabling evaluation of the assumptions that underlie each technique.
2- [2 - [（叔丁基二甲硅烷基）氧基]乙氧基]乙酯（2）和2- [2- [2 - [（叔丁基二甲基硅烷基）氧基]乙氧基]乙氧基]乙酯（3）的阴离子聚合中THF在-78°C下放置2-24小时。阴离子引发剂体系包括1，1-二苯基-3-甲基戊基锂/氯化锂和二苯基甲基钾/二乙基锌。在每种情况下，新型的叔丁基二甲基甲硅烷基保护的低聚（乙二醇）甲基丙烯酸甲酯2和3的聚合反应都进行了定量。所得的聚合物具有基于单体与引发剂的摩尔比的预测分子量，以及较窄的分子量分布（Mw / M n <1.1）。通过使用甲基丙烯酸叔丁酯（tBMA）进行的连续嵌段共聚的定量效率，确定了poly（2）和poly（3）的增长碳负离子的稳定性。明确定义的嵌段共聚物，聚（2） -嵌段-聚（的tBMA）和聚（3） -嵌段-聚（的tBMA），获得。聚（2）和聚（3）的三烷基甲硅烷基保护基）在THF水溶液中于0°C下使用2 N HC
SILANE COUPLING COMPOUNDS AND MEDICAL AND/OR DENTAL CURABLE COMPOSITIONS COMPRISING THE SAME
申请人：KABUSHIKI KAISHA SHOFU
公开号：US20190300552A1
公开（公告）日：2019-10-03
The present invention relate to a novel silane coupling agent and a medical and/or dental curable composition comprising the same. It is an object of the present invention to provide a novel silane coupling agent that imparts high affinity to a radical polymerizable monomer, thereby imparting high mechanical strength, flexibility and durability when used for a medical and/or dental curable composition, and an inorganic filler surface-treated with the novel silane coupling agent and a novel medical and/or dental curable composition. A silane coupling agent including repeating units such as a urethane bond and polyethylene glycol (ether bond) at a specific position is used.
[EN] A DENTAL COMPOSITION<br/>[FR] COMPOSITION DENTAIRE
申请人：STICK TECH OY
公开号：WO2020035321A1
公开（公告）日：2020-02-20
A dental composition comprising10-50 wt-% of a methacrylate-based first matrix component, a polymerisation system and as a second matrix component 1-50 wt-% of a compound having a general formula (I).
ALKALOID MONOMERS, LIQUID CRYSTAL COMPOSITIONS AND POLYMER NETWORKS DERIVED THEREFROM
申请人：Goldfinger Marc B.
公开号：US20110193019A1
公开（公告）日：2011-08-11
Disclosed is the chemical synthesis of chiral alkaloid monomers, liquid crystal compositions comprising the chiral alkaloid monomers, and polymerization of the liquid crystal compositions to provide polymer networks with useful cholesteric optical properties and stability.
COLORING CURABLE RESIN COMPOSITION, CURED FILM, COLOR FILTER, METHOD FOR MANUFACTURING COLOR FILTER, SOLID-STATE IMAGING DEVICE, IMAGE DISPLAY DEVICE, COMPOUND, AND CATION
申请人：FUJIFILM Corporation
公开号：US20160376234A1
公开（公告）日：2016-12-29
The present invention provides a colored curable resin composition that exhibits good heat resistance and durability in a sputtering process, a cured film, a color filter, a method for manufacturing a color filter, a solid-state image device, an image display device, a compound, and a cation. The colored curable resin composition contains a colorant represented by Formula (1), Formula (2), or Formula (3), a resin, a polymerizable compound, and a polymerization initiator. In Formula (1), R
101
and R
102
each independently represent a hydrogen atom or a substituent, R
103
to R
106
each independently represent a hydrogen atom, an alkyl group, an aryl group, or a heteroaryl group, R
107
to R
111
each independently represent a hydrogen atom or a substituent, n1 to n4 each independently represent an integer of 0 to 4, n5 represents an integer of 0 to 6, X represents an anion or is not present, and at least one of R
101
, . . . , or R
111
includes an anion; and in the case where R
101
and R
102
represent hydrogen atoms, R
103
represents an aryl group having a substituent at at least the ortho-position.
[EN] PHOTOINITIATOR AND PHOTOSENSITIVE COMPOSITION INCLUDING THE SAME<br/>[FR] PHOTOAMORCEUR ET COMPOSITION PHOTOSENSIBLE LE CONTENANT
申请人：TAKOMA TECHNOLOGY CO LTD
公开号：WO2015080503A1
公开（公告）日：2015-06-04
Provided is a photoinitiator represented by Formula 1: The photoinitiator is suitable for photocrosslinking. Further provided is a photosensitive resin composition including the photoinitiator. The photoinitiator and the photosensitive resin composition have improved solubility and high sensitivity. The photosensitive resin composition is suitable for use in the production of black resists, color resists, overcoats, column spacers, and organic insulating films for LCDs.
