8-oxo-6,7-dimethylbicyclo[3.2.1]oct-6-ene

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 8-oxo-6,7-dimethylbicyclo[3.2.1]oct-6-ene
• 英文别名: (1S,5R)-6,7-dimethylbicyclo[3.2.1]oct-6-en-8-one
• 化学式: C₁₀H₁₄O
• 分子量: 150.221
• InChiKey: BLUUYOAQSCSEMN-DTORHVGOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.32
• 重原子数：
  11.0
• 可旋转键数：
  0.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  17.07
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  8-oxo-6,7-dimethylbicyclo[3.2.1]oct-6-ene 在 platinum(IV) oxide 吡啶 、 盐酸 、 氢气 、 羟胺 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 甲醇 、 乙醇 、 溶剂黄146 为溶剂， 50.0 ℃ 、5.07 MPa 条件下， 生成
  参考文献：
  名称：

  8-Aminobicyclo[3.2.1]octanes: synthesis and anti-viral activity

  摘要：

  A series of 8-chlorobicyclo[3,2,1]oct-6-enes has been prepared from cyclohexenyl chlorides and simple alkynes via a one-step [3+2] cycloaddition methodology. and then converted into the corresponding bicyclic amines. Against influenza-A virus a number of these showed in vitro activity. and amine (2) was comparable to amantadine in vivo. Good activity against influenza-B virus was less common, and none of the amines showed high potency against both viruses. Amines (20) and (23) showed significant activity versus respiratory syncytial virus. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01593-3
• 作为产物：
  描述：

  3-氯环己烯 在 hydrolysing agent 、 pyridinium chlorochromate 、 zinc(II) chloride 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 生成 8-oxo-6,7-dimethylbicyclo[3.2.1]oct-6-ene
  参考文献：
  名称：

  8-Aminobicyclo[3.2.1]octanes: synthesis and anti-viral activity

  摘要：

  A series of 8-chlorobicyclo[3,2,1]oct-6-enes has been prepared from cyclohexenyl chlorides and simple alkynes via a one-step [3+2] cycloaddition methodology. and then converted into the corresponding bicyclic amines. Against influenza-A virus a number of these showed in vitro activity. and amine (2) was comparable to amantadine in vivo. Good activity against influenza-B virus was less common, and none of the amines showed high potency against both viruses. Amines (20) and (23) showed significant activity versus respiratory syncytial virus. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01593-3

文献信息

• 8-Aminobicyclo[3.2.1]octanes: synthesis and anti-viral activity
  作者：J.A Miller、G.M Ullah、G.M Welsh、A.C Hall

  DOI：10.1016/s0040-4039(01)01593-3

  日期：2001.10

  A series of 8-chlorobicyclo[3,2,1]oct-6-enes has been prepared from cyclohexenyl chlorides and simple alkynes via a one-step [3+2] cycloaddition methodology. and then converted into the corresponding bicyclic amines. Against influenza-A virus a number of these showed in vitro activity. and amine (2) was comparable to amantadine in vivo. Good activity against influenza-B virus was less common, and none of the amines showed high potency against both viruses. Amines (20) and (23) showed significant activity versus respiratory syncytial virus. (C) 2001 Elsevier Science Ltd. All rights reserved.