6-chloro-3-(3-methylamino-propyl)-1-p-tolyl-3,4-dihydro-1H-quinolin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-chloro-3-(3-methylamino-propyl)-1-p-tolyl-3,4-dihydro-1H-quinolin-2-one
• 英文别名: 6-chloro-3-[3-(methylamino)propyl]-1-(4-methylphenyl)-3,4-dihydroquinolin-2-one
• 化学式: C₂₀H₂₃ClN₂O
• 分子量: 342.868
• InChiKey: BOPYYBXXVMRACX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-[(4-甲氧基苯基)甲基]-3,4-二氢喹啉-2-酮 在 N-氯代丁二酰亚胺 、 copper(l) iodide 、 9-borabicyclo[3.3.1]nonane dimer 、 顺-1,3-环己烷二胺 、 potassium carbonate 、 苯甲醚 、 三乙胺 、 三氟乙酸 、 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 乙醇 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 10.5h， 生成 6-chloro-3-(3-methylamino-propyl)-1-p-tolyl-3,4-dihydro-1H-quinolin-2-one
  参考文献：
  名称：

  1-Aryl-3,4-dihydro-1H-quinolin-2-one derivatives, novel and selective norepinephrine reuptake inhibitors

  摘要：

  A novel series of 1-aryl-3,4-dihydro-1H-quinolin-2-ones have been discovered as potent and selective norepinephrine reuptake inhibitors. Efficient synthetic routes have been developed which allow for the multi-gram preparation of both final targets and advanced intermediates for SAR expansion. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.07.038

文献信息

• Quinolone derivatives
  申请人：Camp Paul Nicholas

  公开号：US20070105845A1

  公开（公告）日：2007-05-10

  This invention relates to compounds of formula (I) where —X—, n, R 1 , R 3 and Ar— have the values defined herein, their preparation, and use as pharmaceuticals.

  本发明涉及式（I）化合物，其中—X—，n，R1，R3和Ar—具有在此定义的值，它们的制备以及用作药物的用途。
• 3,4-DIHYDRO-1H-QUINOLIN-2-ONE DERIVATIVES AS NOREPINEPHRINE REUPTAKE INHIBITORS
  申请人：ELI LILLY AND COMPANY

  公开号：EP1622874B1

  公开（公告）日：2007-10-03
• SELECTIVE NOREPINEPHRINE REUPTAKE INHIBITORS FOR THE TREATMENT OF HOT FLASHES, IMPULSE CONTROL DISORDERS AND PERSONALITY CHANGE DUE TO A GENERAL MEDICAL CONDITION
  申请人：ELI LILLY AND COMPANY

  公开号：EP1729754A2

  公开（公告）日：2006-12-13
• Treatment of pervasive developemental disorders with norepinephrine reuptake inhibitors
  申请人：Allen John Albert

  公开号：US20060241188A1

  公开（公告）日：2006-10-26

  Provided are methods and medicaments for treating a Pervasive Developmental Disorder, comprising administering to a patient in need of such treatment an effective amount of a selective norepinephrine reuptake inhibitor.
• Treatment of hot flashes, impulse control disorders and personality change due to a general medical condition
  申请人：Allen John Albert

  公开号：US20070015786A1

  公开（公告）日：2007-01-18

  Selective norepinephrine reuptake inhibitors are useful for the prevention or treatment of hot flashes, vasomotor symptoms, impulse control disorders or personality change due to a general medical condition.