3,6-di-p-coumaroyl sucrose

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 3,6-di-p-coumaroyl sucrose
• 英文别名: lapathoside D；[(2R,3R,4S,5S)-3-hydroxy-5-(hydroxymethyl)-4-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]oxy-5-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-2-yl]methyl (E)-3-(4-hydroxyphenyl)prop-2-enoate
• 化学式: C₃₀H₃₄O₁₅
• 分子量: 634.591
• InChiKey: BZSLWPMWZXMHEW-JSCCKXNGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  45
• 可旋转键数：
  13
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  242
• 氢给体数：
  8
• 氢受体数：
  15

反应信息

• 作为产物：
  描述：

  4-香豆酸 在 四氢吡咯 、 吡啶 、 氯化亚砜 、 水 、 溶剂黄146 作用下， 以 乙醇 、 苯 为溶剂， 反应 51.33h， 生成 3,6-di-p-coumaroyl sucrose
  参考文献：
  名称：

  Lapathoside D及其类似物的合成及其抗肿瘤活性

  摘要：

  苯丙烷类蔗糖酯是植物衍生的天然产物的重要类别，并且由于其结构多样性和广泛的药理和生物活性而具有更大的潜力成为新药的领先者。2,1'：4,6 - O-二异亚丙基蔗糖4与肉桂酰氯5和对乙酰氧基肉桂酰氯6的区域和化学选择性酰化可得到中等程度的单，二，三和四变异PSE产量。由蔗糖3作为廉价的起始原料，在短而简单的合成步骤中就成功地完成了二取代PSE的首个全合成反应，即Lapathoside D 1 ' 。Lapathoside D 1测试了一组选定的合成PSE对人宫颈上皮样癌（HeLa）细胞系的体外细胞毒性。大多数化合物显示出显着的抗肿瘤活性，其IC 50值为0.05至7.63μM。初步筛选结果表明，PSE可能是新的有效抗癌药物候选者的宝贵来源。

  DOI：

  10.1016/j.ejmech.2012.02.032

文献信息

• Use of neoflavonoids for flavor modification
  申请人：Backes Michael

  公开号：US20130078192A1

  公开（公告）日：2013-03-28

  The present invention relates primarily to the use of one or a plurality of neoflavonoids of formula (I) and/or one or a plurality of physiologically acceptable salts of one or a plurality of neoflavonoids of formula (I) for flavor modification, in particular for altering or masking a bitter, astringent and/or metallic flavor impression of a bitter, astringent and/or metallic tasting substance and a corresponding method of flavor modification. The present invention further relates to certain mixtures and certain preparations fit for consumption containing one or a plurality of neoflavonoids of formula (I) and/or one or a plurality of physiologically acceptable salts of one or a plurality of neoflavonoids of formula (I).

  本发明主要涉及使用公式(I)的一个或多个新黄酮类化合物和/或公式(I)的一个或多个生理上可接受的盐来进行风味改良，特别是用于改变或掩盖苦、收敛和/或金属口感物质的苦、收敛和/或金属风味印象及相应的风味改良方法。本发明还涉及某些混合物和某些适合食用的制剂，其中包含公式(I)的一个或多个新黄酮类化合物和/或公式(I)的一个或多个生理上可接受的盐。
• Plant extract comprising sucrose esters as an active agent for use in cosmetic, dermatological or nutricosmetic composition
  申请人：COSMO INTERNATIONAL INGREDIENTS

  公开号：US10555894B2

  公开（公告）日：2020-02-11

  The invention relates to a plant extract from the calyx of one of the many plants of the Solanaceae family, of the Physalis genus, comprising mainly one or more moderately polar to non-polar sucrose esters having a carbon number of acyl groups from C1 to C10 for use as an active agent in cosmetic, dermatological or nutracosmetic compositions. It also relates to the purified sucrose esters of the plant extract or the synthesised sucrose esters as described for the same use. The invention also relates to a cosmetic, dermatological or nutracosmetic composition comprising as active ingredient, a plant extract or the synthesised sucrose esters in a suitable physiological medium. Finally, it also relates to the preparation method of the said plant extract.

  本发明涉及一种从茄科 Physalis 属多种植物之一的花萼中提取的植物萃取物，该萃取物主要包含一种或多种中等极性至非极性的蔗糖酯，其酰基的碳原子数为 C1 至 C10，可用作化妆品、皮肤病学或营养化妆品组合物中的活性剂。本发明还涉及纯化的植物提取物蔗糖酯或用于相同用途的合成蔗糖酯。 本发明还涉及一种化妆品、皮肤剂或营养化妆品组合物，其活性成分包括在适当生理介质中的植物提取物或合成蔗糖酯。 最后，本发明还涉及上述植物提取物的制备方法。
• Verwendung von Neoflavonoiden zur Geschmacksmodifizierung
  申请人：Symrise AG

  公开号：EP2570035B1

  公开（公告）日：2014-06-18
• EXTRAIT VÀ‰GÉTAL COMPRENANT DES SUCROSE-ESTERS EN TANT QUE PRINCIPE ACTIF POUR SON UTILISATION DANS UNE COMPOSITION COSMÉTIQUE, DERMATOLOGIQUE OU NUTRACOSMÉTIQUE
  申请人：Cosmo International Ingredients

  公开号：EP3091960A1

  公开（公告）日：2016-11-16
• Use of certain neoflavonoids for intensifying and/or producing a sensory impression of sweetness
  申请人：Backes Michael

  公开号：US20130084252A1

  公开（公告）日：2013-04-04

  The present invention primarily relates to the use of one or a plurality of neoflavonoids of formula (I) and/or one or a plurality of physiologically acceptable salts of one or a plurality of neoflavonoids of formula (I) for producing a sensory impression of sweetness (i.e. an impression of sweetness) in an orally consumable preparation or for intensifying the sensory impression of sweetness of an orally consumable preparation comprising at least one further sweet-tasting and/or sweet-smelling substance. The present invention further relates to certain semifinished products and certain orally consumable preparations containing one or a plurality of neoflavonoids of formula (I) and/or one or a plurality of physiologically acceptable salts of one or a plurality of neoflavonoids of formula (I). Finally the invention also relates to a method of producing an orally consumable preparation and a method of producing and/or intensifying a sensory impression of sweetness in/of an orally consumable preparation.