双(2-羰氧苄基)琥珀酸盐 | 578-19-8

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 双(2-羰氧苄基)琥珀酸盐
• 中文别名: 琥珀醯柳酸
• 英文名称: bis(o-carboxyphenyl)succinate
• 英文别名: succinylsalicylic acid；diaspirin；2,2'-succinyldioxy-di-benzoic acid；2,2'-Succinyldioxy-di-benzoesaeure；Bernsteinsaeure-bis-(2-carboxy-phenylester)；Succinyldisalicylsaeure；Succinyldisalicylic acid；2-[4-(2-carboxyphenoxy)-4-oxobutanoyl]oxybenzoic acid
• CAS: 578-19-8
• 化学式: C₁₈H₁₄O₈
• 分子量: 358.304
• InChiKey: PREOBXYMXLETCA-UHFFFAOYSA-N

物化性质

• 熔点：
  160-165 °C(lit.)
• 沸点：
  610.0±50.0 °C(Predicted)
• 密度：
  1.429±0.06 g/cm3(Predicted)
• 稳定性/保质期：
  在常温常压下，该物质是稳定的。

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  127
• 氢给体数：
  2
• 氢受体数：
  8

安全信息

• 危险性防范说明：
  P261,P280,P301+P312,P302+P352,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335
• 储存条件：
  常温、密闭、避光、存于通风干燥处。

反应信息

• 作为反应物：
  描述：

  holmium(III) nitrate hexahydrate 、 双(2-羰氧苄基)琥珀酸盐 在 triethylamine 作用下， 以 水 为溶剂， 生成
  参考文献：
  名称：

  Structure-Directing and Template Roles of Aromatic Molecules in the Self-Assembly Formation Process of 3D Holmium–Succinate MOFs

  摘要：

  Two new holmium-succinate frameworks have been synthesized by hydrolysis in situ of the succinylsalicylic acid under different hydrothermal conditions. Compound 1, [Ho-2(C4H4O4)(3)(H2O)(2)] center dot 0.33(C7H6O3), P (i) over bar space group, has a novel structure composed by 1D-SBUs consisting of [HoO9] chains of polyhedra linked by the succinate ligands giving a 3D framework. Compound 2, [Ho-2(C4H4O4)(3)(H2O)(2)], also belonging to the P (i) over bar space group, has a denser structure. The role of the in-situ-generated salicylic acid on formation of both structures is studied by means of a synthesis design methodology. A topological study of the new holmium succinate compounds in comparison with the previously reported 3D holmium-succinate framework is performed here.

  DOI：

  10.1021/ic102472u
• 作为产物：
  描述：

  丁二酰氯 、 水杨酸 在 吡啶 作用下， 以 水 、 丙酮 为溶剂， 以66.5 grams (93%)的产率得到双(2-羰氧苄基)琥珀酸盐
  参考文献：
  名称：

  Anticalculus oral composition

  摘要：

  本发明公开了一种基本无水的口腔成分，基本上不含有通常会导致着色的抗菌抗牙菌斑剂，并含有有效的抗牙石量的C.sub.2-8脂肪族二羧酸的双(邻羧苯基)酯，例如双(邻羧苯基)琥珀酸酯。

  公开号：

  US04474750A1

文献信息

• Pegylated non-hypertensive hemoglobins, methods of preparing same, and uses thereof
  申请人：Acharya A. Seetharama

  公开号：US20050159339A1

  公开（公告）日：2005-07-21

  The present invention provides pegylated hemoglobins comprising a thiocarbamoyl-phenyl-polyethylene glycol (PEG) attached to hemoglobin, and comprising a polyethylene glycol (PEG) attached to hemoglobin by an acyl group. The invention also provides methods of preparing pegylated hemoglobins using isothiocyanato phenyl carbamate of PEG and using isothiocyanato phenyl di-PEG carbamate. The invention further provides compositions and blood substitutes comprising pegylated hemoglobins and methods of treating a subject which comprise administering to the subject blood substitutes comprising non-hypertensive pegylated hemoglobins.

  本发明提供了包含硫代氨基甲酰基苯基聚乙二醇（PEG）连接到血红蛋白的聚乙二醇化血红蛋白，以及包含通过酰基连接到血红蛋白的聚乙二醇（PEG）的聚乙二醇化血红蛋白。该发明还提供了使用PEG的异硫氰酸苯基氨基甲酸酯和使用异硫氰酸苯基二PEG氨基甲酸酯制备聚乙二醇化血红蛋白的方法。该发明还提供了包含聚乙二醇化血红蛋白的组合物和血液替代品，以及治疗受试者的方法，包括向受试者施用包含非高血压聚乙二醇化血红蛋白的血液替代品。
• Therapeutic methods employing disulfide derivatives of dithiocarbamates and compositions useful therefor
  申请人：Medinox, Inc.

  公开号：US20030181495A1

  公开（公告）日：2003-09-25

  The present invention provides novel combinations of dithiocarbamate disulfide dimers with other active agents. In one method, the disulfide derivative of a dithiocarbamate is coadministered with a thiazolidinedione for the treatment of diabetes. In another embodiment, In another embodiment, invention combinations further comprise additional active agents such as, for example, metformin, insulin, sulfonylureas, and the like. In another embodiment, the present invention relates to compositions and formulations useful in such therapeutic methods.

  本发明提供了二硫代氨基甲酸盐二硫化二聚体与其他活性药剂的新组合。在一种方法中，二硫代氨基甲酸盐的二硫化衍生物与噻唑烷二酮联合用于治疗糖尿病。在另一实施例中，该发明的组合进一步包括额外的活性药剂，例如二甲双胍、胰岛素、磺酰脲类药物等。在另一实施例中，本发明涉及用于这种治疗方法的组合物和配方。
• Long lasting waterproof sunscreen comprising metal oxide and peptide conditioner
  申请人：Buseman-Williams Janine

  公开号：US20050249682A1

  公开（公告）日：2005-11-10

  The disclosure provides a sunscreen formulation comprising a peptide-based metal oxide sunscreen agent, such as titanium dioxide nanoparticles, and a fluid vehicle.

  本公开提供了一种防晒配方，包括基于肽的金属氧化物防晒剂，例如二氧化钛纳米颗粒，以及流体载体。
• HEMOGLOBIN-ALBUMIN COMPLEX, AND ARTIFICIAL PLASMA EXPANDER AND ARTIFICIAL OXYGEN CARRIER CONTAINING THE COMPLEX
  申请人：Komatsu Teruyuki

  公开号：US20130338342A1

  公开（公告）日：2013-12-19

  A novel hemoglobin-albumin complex which has high stability of the oxygenated form, has high biocompatibility, and is easily prepared (synthesized), and an artificial plasma expander and an artificial oxygen carrier containing the complex are provided. The hemoglobin-albumin complex of the invention is characterized by having hemoglobin as the core, and albumin as the shell bound via a crosslinker to the above hemoglobin. Also, the artificial oxygen carrier of the invention is characterized by containing the hemoglobin-albumin complex of the invention.

  本发明提供了一种新型血红蛋白-白蛋白复合物，其具有高稳定性的氧合形式，具有高生物相容性，易于制备（合成），以及含有该复合物的人工血浆扩容剂和人工氧载体。本发明的血红蛋白-白蛋白复合物的特点是以血红蛋白为核心，通过交联剂与上述血红蛋白结合的白蛋白为外壳。此外，本发明的人工氧载体的特点是包含本发明的血红蛋白-白蛋白复合物。
• Composition and method to inhibit the growth of organisms by the use of bis-biguanido hexanes and essential oil mixture combinations
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0244363A1

  公开（公告）日：1987-11-04

  Novel antimicrobial compositions having a synergistic combination of a bis-biguanido hexane compound and a mixture of at least two essential oils and a method for treating teeth to inhibit or prevent dental caries and plaque.

  新颖的抗菌组合物，具有双双关胍基己烷化合物和至少两种精油混合物的协同组合，以及一种治疗牙齿以抑制或预防龋齿和牙菌斑的方法。