呋罗达唑 | 56119-96-1

• 物质功能分类: 原料药 - 抗寄生虫病药 - 驱肠虫药
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 呋罗达唑
• 英文名称: 2-furan-2-yl-7-methyl-1(3),6-dihydro-imidazo[4,5-f]quinolin-9-one
• 英文别名: 2-(2-Furyl)-7-methyl-1H-imidazo[4,5-f]quinolin-9-ol；Furodazole；2-(furan-2-yl)-7-methyl-3,6-dihydroimidazo[4,5-f]quinolin-9-one
• CAS: 56119-96-1
• 化学式: C₁₅H₁₁N₃O₂
• 分子量: 265.271
• InChiKey: NYRSQWAKUMYFLI-UHFFFAOYSA-N

物化性质

• 熔点：
  280-282 °C(Solv: nitromethane (75-52-5))
• 沸点：
  555.7±60.0 °C(Predicted)
• 密度：
  1.432±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  70.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  ethyl (E)-3-[[2-(furan-2-yl)-3H-benzimidazol-5-yl]amino]but-2-enoate 以74%的产率得到
  参考文献：
  名称：

  ALAIMO R. J.; SPENCER C. F.; SHEFFER J. B.; STORRIN R. J.; HATTON C. J.; +, J. MED. CHEM. , 1978, 21, NO 3, 298-300

  摘要：

  DOI：

文献信息

• [EN] COMPOUNDS FOR THE TREATMENT OF AMYLOID-ASSOCIATED DISEASES<br/>[FR] COMPOSÉS POUR LE TRAITEMENT DE MALADIES ASSOCIÉES À LA SUBSTANCE AMYLOÏDE
  申请人：REMYND NV

  公开号：WO2016083490A1

  公开（公告）日：2016-06-02

  This invention provides novel compounds of formulae (I) or (II) or a stereoisomer, enantiomer, racemic, or tautomer thereof, (I) (II) wherein the substituents are as defined in the specification. The present invention also relates to the novel compounds for use as a medicine, more in particular for the prevention or treatment of amyloid-related diseases, more specifically certain neurological disorders, such as disorders collectively known as tauopathies, disorders characterized by cytotoxic α-synuclein amyloidogenesis. The present invention also relates to the use of said novel compounds for the manufacture of medicaments useful for treating such amyloid-related diseases. The present invention further relates to pharmaceutical compositions including said novel compounds and to methods for the preparation of said novel compounds.

  这项发明提供了式(I)或(II)或其立体异构体、对映异构体、消旋体或互变异构体的新化合物，其中取代基如规范中所定义。本发明还涉及用作药物的这些新化合物，更具体地用于预防或治疗与淀粉样蛋白相关的疾病，更具体地说是某些神经系统疾病，如被统称为tau病变的疾病，以及由细胞毒性α-突触核蛋白淀粉生成所特征化的疾病。本发明还涉及利用这些新化合物制备对治疗此类淀粉样蛋白相关疾病有用的药物。本发明还涉及包括这些新化合物的药物组合物以及这些新化合物的制备方法。
• Imidazo(4,5-f)quinolines useful as immunomodulating agents
  申请人：Norwich Eaton Pharmaceuticals, Inc.

  公开号：US04716168A1

  公开（公告）日：1987-12-29

  The present invention involves compounds of the class of imidazo[4,5-f]quinolines and methods for enhancing the immune response system of mammals which comprises systemically administering to mammals having a depressed immune function an effective but nontoxic amount of a composition comprising such a compound.

  本发明涉及咪唑并[4,5-f]喹啉类化合物以及增强哺乳动物免疫应答系统的方法，包括向免疫功能受抑制的哺乳动物全身给予含有这种化合物的组合物的有效但无毒剂量。
• Imidazo[4,5-f]quinolines. 4. Synthesis and anthelmintic activity of a series of imidazo[4,5-f]quinolin-9-ols
  作者：Robert J. Alaimo、Claude F. Spencer、James B. Sheffer、Ronald J. Storrin、Christopher J. Hatton、Robert E. Kohls

  DOI：10.1021/jm00201a014

  日期：1978.3

  A series of 2-arylimidazo[4,5-f]quinolin-9-ols has been prepared by a multistep procedure from various 5-aminobenzimidazoles. These compounds possess a significant degree of anthelmintic activity against the mouse tapeworm Hymenolepis nana. The most active compound is the 2-(2-furyl) analogue. Additional anthelmintic testing is reported for this compound.

  已经通过各种步骤由各种5-氨基苯并咪唑制备了一系列2-芳基咪唑并[4，5-f]喹啉-9-醇。这些化合物对小鼠tape虫Hymenolepis nana具有显着的驱虫活性。活性最高的化合物是2-（2-呋喃基）类似物。据报道该化合物还进行了驱虫试验。
• US4716168A
  申请人：——

  公开号：US4716168A

  公开（公告）日：1987-12-29
• ALAIMO R. J.; SPENCER C. F.; SHEFFER J. B.; STORRIN R. J.; HATTON C. J.; +, J. MED. CHEM. <JMCM-AR>, 1978, 21, NO 3, 298-300
  作者：ALAIMO R. J.、 SPENCER C. F.、 SHEFFER J. B.、 STORRIN R. J.、 HATTON C. J.、 +

  DOI：——

  日期：——