trans-N-methyl-N-phenyl-2-isopropylcyclopentanecarboxamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: trans-N-methyl-N-phenyl-2-isopropylcyclopentanecarboxamide
• 英文别名: (1S,2R)-N-methyl-N-phenyl-2-propan-2-ylcyclopentane-1-carboxamide
• 化学式: C₁₆H₂₃NO
• 分子量: 245.365
• InChiKey: YVJVRXFMIAEZKW-CABCVRRESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  5-甲基-4-己烯酸 在 氢氧化钾 、 sodium hydroxide 、 lithium aluminium tetrahydride 、 正丁基锂 、 氯化亚砜 、 偶氮二异丁腈 、 三正丁基氢锡 、 sodium hydride 、 三乙胺 、 二异丙胺 、 sodium iodide 作用下， 以 四氢呋喃 、 乙醚 、 二氯甲烷 、 水 、 丙酮 、 苯 为溶剂， 反应 42.75h， 生成 trans-N-methyl-N-phenyl-2-isopropylcyclopentanecarboxamide
  参考文献：
  名称：

  Amide-based protecting/radical translocating (PRT) groups. Generation of radicals adjacent to carbonyls by 1,5-hydrogen transfer reactions of o-iodoanilides

  摘要：

  The o-iodoanilide group is shown to be broadly useful for the generation and subsequent reactions of radicals adjacent to carboxyl groups. The results indicate that this group is one of the best ''protecting/radical translocating'' (PRT) groups introduced to date. Beyond its good performance in radical translocation reactions, it is easy to introduce, serves as a reasonable protecting group both before and after the translocation, and (with appropriate modifications) is easy to remove.

  DOI：

  10.1016/s0040-4020(01)90466-1

文献信息

• Amide-based protecting/radical translocating (PRT) groups. Generation of radicals adjacent to carbonyls by 1,5-hydrogen transfer reactions of o-iodoanilides
  作者：Dennis P. Curran、Hosung Yu、Hongtao Liu

  DOI：10.1016/s0040-4020(01)90466-1

  日期：——

  The o-iodoanilide group is shown to be broadly useful for the generation and subsequent reactions of radicals adjacent to carboxyl groups. The results indicate that this group is one of the best ''protecting/radical translocating'' (PRT) groups introduced to date. Beyond its good performance in radical translocation reactions, it is easy to introduce, serves as a reasonable protecting group both before and after the translocation, and (with appropriate modifications) is easy to remove.