Polymeric diphenylmethane diisocyanate is a dark-brown liquid with a weak odor. Sinks in water. (USCG, 1999)
颜色/状态：
DARK-AMBER VISCOUS LIQUID
熔点：
200°C
蒸汽压力：
LESS THAN 1X10-4 MM HG @ 25 °C
稳定性/保质期：
在常温常压下保持稳定，应避免接触强氧化剂。
计算性质
辛醇/水分配系数(LogP)：
1.47
重原子数：
11
可旋转键数：
1
环数：
1.0
sp3杂化的碳原子比例：
0.0
拓扑面积：
46.5
氢给体数：
0
氢受体数：
3
ADMET
毒理性
致癌性证据
没有关于人类的数据。没有关于动物的数据。总体评估：第3组：该物质无法归类为对人类的致癌性。
No data are available in humans. No data are available in animals. OVERALL EVALUATION: Group 3: The agent is not classifiable as to its carcinogenicity to humans.
WEIGHT OF EVIDENCE CHARACTERIZATION: Under U.S. EPA's 1996 Guidelines for Carcinogenic Risk Assessment, monomeric MDI or polymeric MDI (PMDI) would be classified as not classifiable or a Group D chemical. Under U.S. EPA's 1996 Proposed Guidelines for Carcinogenic Risk Assessment, the carcinogenic potential of MDI/PMDI would be characterized as "cannot be determined, but for which there is suggestive evidence that raises concern for carcinogenic effects" on the following basis. The increased incidence of pulmonary adenomas in male (6/60) and female (2/59) Wistar rats [strain Cpu:WU] and one pulmonary adenocarcinoma in a male rat, all exposed to the highest concentration in a lifetime chronic inhalation study involving PMDI, suggest that PMDI has tumorigenic potential. However, the tumorigenic results, coupled with evidence that methylene diphenyl aniline (MDA) a known animal carcinogen and the principal reaction product of MDI, is found in blood of MDI-exposed rats and nonhydrolyzed urine of PMDI/MDI-exposed humans increases concern about the carcinogenic potential of PMDI/MDI. The available human evidence is inadequate to describe the carcinogenic potential of PMDI/MDI. HUMAN CARCINOGENICITY DATA: Inadequate. ANIMAL CARCINOGENICITY DATA: Limited.
来源:Hazardous Substances Data Bank (HSDB)
毒理性
致癌性证据
美国环保局-柴油机
EPA-D
来源:Occupational Safety and Health Administration (OSHA)
毒理性
健康影响
健康影响代码：HE9 - 除刺激外的心肺效应 - 呼吸道过敏（哮喘或其他）
Health Effect Code(s):HE9 - Respiratory Effects Other Than Irritation---Respiratory sensitization (asthma or other)
来源:Occupational Safety and Health Administration (OSHA)
IDENTIFICATION AND USES: Polymethylene polyphenyl isocyanate is a dark amber viscous liquid. It is used as a binder resin for particle board and as a foundry core binder resin. HUMAN EXPOSURE AND TOXICITY: Isocyanates are irritating to the skin and mucous membranes, the skin conditions range from localized itching to wide spread eczema. Eye affections are less common and lacrimation is noted. The incidence of conjunctivitis is rare. Isocyanates have serious effects on lung tissue. Individuals who are at risk from adverse effects of isocyanates include those with a history of asthma, allergies, impaired lung or pulmonary function. Evidence of Carcinogenicity: No evidence in humans. ANIMAL STUDIES: The increased in pulmonary adenomas in male and female Wistar rats were noted in a lifetime chronic inhalation study. In industry reports five albino rats exposed to this chemical by single doses exhibited salivation, nasal discharge and abnormal yellow discoloration. Gross necropsy revealed no abnormalities. ChR-CD male rats administered single doses of polymethylene polyphenyl isocyanate by oral gavage, gross necropsy revealed eroded and thickened stomach mucosa and masses in the stomach. Microscopic histopathology discovered depletion of thymocytes, reduced liver cell vacuolation and focal inflammation of the liver. Rabbits receiving single occluded applications of undiluted polymethylene polyphenyl isocyanate showed slight skin erythema and slight coriaceousness at the application site. No effects were observed at necropsy. Lung congestion was observed in Albino Spartan Sprague-Dawley rats exposed by inhalation to this chemical. A carcinogenicity study of polymethylene polyphenyl isocyanate in Cpb:WU, Wistar random rats exposed by inhalation showed mortality rates were negatively correlated with concentration. Effects included basal cell hyperplasia and hyperplasia of Bowman's glands in the olfactory epithelium of the nose, alveolar duct epithelia, alveolar duct fibrosis in tissues surrounding macrophage accumulations. Increases in lung weights along with calcerous particles in lungs and localized areas of bronchiolisation and pulmonary adenomas and a pulmonary adenocarcinoma were noted. In Long-Evans rats exposed by inhalation of polymethylene polyphenyl isocyanate vapors clinical observations included respiratory distress in the form of rales. Gross necropsy revealed no treatment changes. In Salmonella typhimurium tester strains TA1535, TA1537 and TA1538 (Ames test) with or without metabolic activation did not produce positive results in any strain tested.
Pyrithione compound and microcapsule using the same
申请人：Sugai Masaharu
公开号：US20050271736A1
公开（公告）日：2005-12-08
A compound represented by formula (I); a multifunctional isocyanate composition, containing an adduct formed by treating the compound represented by formula (I) with a compound represented by formula (II); and a microcapsule using the multifunctional isocyanate composition:
wherein, in formula (I), R
1
represents -L
1
-X
1
or X
1
; R
2
represents a hydrogen atom or -L
2
-X
2
; L
1
and L
2
each independently represent a divalent linking group; X
1
and X
2
each independently represent a nucleophilic substituent; n represents an integer of 1 to 4; and when n is 2 or more, R
1
s may be the same or different; and
R
3
—(NCO)
m
Formula (II)
wherein, in formula (II), R
3
represents an arbitrary m-valent linking group; and m represents an integer of 2 or above.
