1,6-己二醇乙氧酸二丙烯酸酯 | 84170-27-4

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 1,6-己二醇乙氧酸二丙烯酸酯
• 英文名称: 1,6-hexanediol ethoxylate diacrylate
• 英文别名: 2-[6-(2-prop-2-enoyloxyethoxy)hexoxy]ethyl prop-2-enoate
• CAS: 84170-27-4；226722-38-9
• 化学式: C₁₆H₂₆O₆
• 分子量: 314.379
• InChiKey: GIMNDOUZTMKUHI-UHFFFAOYSA-N

物化性质

• 密度：
  1.01 g/mL at 25 °C (lit.)
• 保留指数：
  2131

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  22
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  6

安全信息

• 危险等级：
  6.1(b)

反应信息

• 作为反应物：
  描述：

  1,6-己二醇乙氧酸二丙烯酸酯 、 二苯基膦 以 2-甲基四氢呋喃 为溶剂， 反应 8.0h， 以76%的产率得到C₄₀H₄₈O₆P₂
  参考文献：
  名称：

  烯烃在 2-甲基四氢呋喃存在下的无催化剂氢膦化反应：一种绿色且易于获得各种叔膦的方法†

  摘要：

  已经进行了不含碱、酸和催化剂的氢膦化反应，仅使用 2-甲基四氢呋喃作为添加剂。通过将二苯基膦添加到烯烃、单官能和多官能丙烯酸树脂（基于丙烯酸酯和甲基丙烯酸酯基体）和丙烯酰胺基材中，可以以良好至优异的产率获得一系列新的单、二、三和四膦化合物。将四当量的生物质衍生的 2-MeTHF 添加到反应介质中可以提高转化率和反应时间，并降低反应物对氧化的敏感性。这种简单、直接和原子经济的方法尊重绿色化学的原则。此外，在每种情况下，这种转化都显示出对反马尔科夫尼科夫产物的专有区域选择性。

  DOI：

  10.1039/c9ra04896k

文献信息

• ANTIOXIDANT POLYMERS CONTAINING [1,2]-DITHIOLANE MOIETIES AND USES THEREOF
  申请人：Yu John S.

  公开号：US20100098653A1

  公开（公告）日：2010-04-22

  The present invention describes polymers containing 1,2-dithiolanes capable of acting as scavengers of free radicals, metals and reactive oxygen species. Also described are methods of synthesizing the antioxidant 1,2-dithiolane derivatives and polymerization thereof to produce biodegradable antioxidant polymers. The antioxidant polymers of the present invention may be used to treat diseases or conditions caused by oxidative stress and other free radical mediated conditions. The antioxidant polymers may also be used for the preparation of antioxidant particulate delivery devices of therapeutic agents.

  本发明描述了含有1,2-二硫杂环的聚合物，能够作为自由基、金属和活性氧化物的清除剂。还描述了合成抗氧化剂1,2-二硫杂环衍生物和聚合物的方法，用于制备可生物降解的抗氧化剂聚合物。本发明的抗氧化剂聚合物可用于治疗由氧化应激和其他自由基介导的疾病或病情。抗氧化剂聚合物还可用于制备治疗剂的抗氧化颗粒递送装置。
• NANOCOMPOSITES OF GOLD AND POLYMERS
  申请人：THE JOHNS HOPKINS UNIVERSITY

  公开号：US20140294909A1

  公开（公告）日：2014-10-02

  A layer-by-layer (LbL) system, which alternately ionically complexes anionic AuNPs to two unique cationic polymers (disulfide-reducible and hydrolytically degradable) and two anionic nucleic acids, is disclosed.

  本文介绍了一种逐层（LbL）系统，该系统交替离子复合两种独特的阳离子聚合物（二硫键可还原和水解降解）和两种阴离子核酸到阴离子AuNPs上。
• A BIOMIMETIC PEPTIDE AND BIODEGRADABLE DELIVERY PLATFORM FOR THE TREATMENT OF ANGIOGENESIS- AND LYMPHANGIOGENESIS-DEPENDENT DISEASES
  申请人：The Johns Hopkins University

  公开号：EP3003343B1

  公开（公告）日：2019-10-23
• CROSSLINKED, DEGRADABLE POLYMERS AND USES THEREOF
  申请人：Anderson Daniel Griffith

  公开号：US20080145338A1

  公开（公告）日：2008-06-19

  Acrylate-terminated poly(beta-amino esters) are cross-linked to form materials useful in the medical as well as non-medical field. The polymeric starting material is combined with a free radical initiator, either a thermal initiator or a photoinitiator, and the mixture for cross-linking is heated or exposed to light depending on the initiator used. The resulting materials due to the hydrolysable ester bond in the polymer backbone are biodegradable under physiological conditions. These cross-linked materials are particular useful as drug delivery vehicles, tissue engineering scaffolds, and in fabricating microdevices. The materials may also be used as plastics, coating, adhesives, inks, etc. The cross-linked materials prepared exhibit a wide range of degradation times, mass loss profiles, and mechanical properties. Therefore, the properties of the material may be tuned for the desired use. The high-throughput approach to preparing a library of cross-linked poly(beta-amino esters) allows for the rapid screening and design of degradable polymers for a variety of applications.
• End-Modified Poly(beta-amino esters) and Uses Thereof
  申请人：Zugates Gregory T.

  公开号：US20080242626A1

  公开（公告）日：2008-10-02

  Poly(beta-amino esters) are end-modified to form materials useful in the medical as well as non-medical field. An amine-terminated poly(beta-amino ester) is reacted with an electrophile, or an acrylate-terminated poly(beta-amino ester) is reacted with a nucleophile. The inventive end-modified polymers may be used in any field where polymers have been found useful including the drug delivery arts. The end-modified polymers are particularly useful in delivery nucleic acids such as DNA or RNA. The invention also provides compositions including the inventive end-modified polymers, methods of preparing the inventive polymers, and method of using the inventive polymers.