1-(2-甲氧基苯基)-1H-吡唑-4-甲醛 | 1013835-99-8

• 物质功能分类: 有机原料 - 醛类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 1-(2-甲氧基苯基)-1H-吡唑-4-甲醛
• 中文别名: 1-(2-甲氧基苯基)吡唑-4-甲醛；1-(2-甲氧苯基)吡唑-4-甲醛；N-(2-甲氧苯基)-吡唑-4-甲醛
• 英文名称: 1-(2-methoxyphenyl)-1H-pyrazole-4-carbaldehyde
• 英文别名: 1-(2-methoxyphenyl)pyrazole-4-carbaldehyde
• CAS: 1013835-99-8
• 化学式: C₁₁H₁₀N₂O₂
• 分子量: 202.21
• InChiKey: XMYPVLUGOKWAFL-UHFFFAOYSA-N

物化性质

• 沸点：
  360.6±22.0 °C(Predicted)
• 密度：
  1.18±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  44.1
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2933199090

文献信息

• [EN] TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE<br/>[FR] INHIBITEURS, À BASE DE TRIAZOLOPYRIDINE, DE LA MYÉLOPEROXYDASE
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2017040449A1

  公开（公告）日：2017-03-09

  The present invention provides compounds of Formula (I): wherein A is as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, which may be used as medicaments.

  本发明提供了化合物的结构式（I）：其中A如规范中定义，并包括任何此类新化合物的组合物。这些化合物是髓过氧化物酶（MPO）抑制剂和/或嗜酸性粒细胞过氧化物酶（EPX）抑制剂，可用作药物。
• NOVEL COMPOUND AS MTOR INHIBITOR AND USE THEREOF
  申请人：Medicinal Bioconvergence Research Center

  公开号：EP3786163A1

  公开（公告）日：2021-03-03

  The present invention relates to a novel compound as an mTOR inhibitor and a use thereof and, more specifically, to a novel compound represented by formula 1 that exhibits mTOR inhibitory activity and a pharmaceutical composition comprising same as an active ingredient for preventing or treating brain diseases associated with an mTOR pathway.

  本发明涉及一种作为mTOR抑制剂的新化合物及其用途，更具体地，涉及一种由式1表示的新化合物，该化合物表现出mTOR抑制活性，并且包括该化合物作为活性成分的药物组合物，用于预防或治疗与mTOR途径相关的脑疾病。
• Acyl Piperazine Derivatives as TTX-S Blockers
  申请人：Morita Mikiko

  公开号：US20130150356A1

  公开（公告）日：2013-06-13

  The present invention relates to acyl piperazine derivatives which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.

  本发明涉及酰基哌嗪衍生物，具有阻断电压门控钠通道（TTX-S通道）的活性，并且在治疗或预防涉及电压门控钠通道的疾病和疾病方面非常有用。本发明还涉及包含这些化合物的制药组合物以及在预防或治疗涉及电压门控钠通道的疾病中使用这些化合物和组合物的用途。
• Triazolopyridine inhibitors of myeloperoxidase
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US10407422B2

  公开（公告）日：2019-09-10

  The present invention provides compounds of Formula (I): wherein A is as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, which may be used as medicaments.

  本发明提供了式(I)化合物：其中A如说明书中所定义，以及包含任何此类新型化合物的组合物。 这些化合物是髓过氧化物酶（MPO）抑制剂和/或嗜酸性粒细胞过氧化物酶（EPX）抑制剂，可用作药物。
• TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20190023701A1

  公开（公告）日：2019-01-24

  The present invention provides compounds of Formula (I): wherein A is as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, which may be used as medicaments.