桑根皮醇 | 62949-93-3

• 物质功能分类: 天然产物 - 黄酮类化合物
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 中文名称: 桑根皮醇
• 英文名称: Morusinol
• 英文别名: oxydihydromorusin；2-(2,4-dihydroxyphenyl)-5-hydroxy-3-(3-hydroxy-3-methylbutyl)-8,8-dimethylpyrano[2,3-h]chromen-4-one
• CAS: 62949-93-3
• 化学式: C₂₅H₂₆O₇
• 分子量: 438.477
• InChiKey: AFOKZNPZDXHDHD-UHFFFAOYSA-N

物化性质

• 熔点：
  213-214 °C
• 沸点：
  699.6±55.0 °C(Predicted)
• 密度：
  1.341±0.06 g/cm3(Predicted)
• 溶解度：
  溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  116
• 氢给体数：
  4
• 氢受体数：
  7

制备方法与用途

用途

桑根皮醇是从黄芪散的有效部位中提取的一种天然产物。黄芪散方源自《圣济总录》，由葛根、黄芪和桑白皮组成，主要用于治疗三消渴疾（即糖尿病）、肌肤瘦弱及饮水不休、小便不止等症状。

生物活性

Morusinol 是从桑树根皮中分离出的一种类黄酮。研究表明，Morusinol 具有抗血小板活性，并能在体内显著抑制动脉血栓形成。

靶点

• IC50: 动脉血栓形成

文献信息

• COMPOSITIONS AND METHODS FOR MANAGING WEIGHT
  申请人：Unigen, Inc.

  公开号：US20140004215A1

  公开（公告）日：2014-01-02

  The present disclosure provides Diels-Alder adducts of chalcone and prenylphenyl moieties capable of modulating the activity of cannabinoid receptors, and to oligomers of flavan-3-ol capable of modulating fat absorption and storage. Such Diels-Alder adducts of chalcone and prenylphenyl moieties or oligomers of flavan-3-ol can optionally be used in combination with other weight management agents, such as anorectic agents, a lipase inhibitors, other cannabinoid receptor modulators, psychotropic agents, insulin sensitizers, stimulants, or satiety agents, as well as to methods of use thereof such as treating or preventing weight gain or obesity, promoting weight loss, appetite suppression, modifying satiety, or the like.

  本公开提供了香豆素和异戊烯基苯基基团的Diels-Alder加合物，能够调节大麻素受体的活性，以及能够调节脂肪吸收和储存的黄烷类三酚寡聚体。这些香豆素和异戊烯基苯基团的Diels-Alder加合物或黄烷类三酚寡聚体可以选择性地与其他减重药物联合使用，例如厌食剂、脂肪酶抑制剂、其他大麻素受体调节剂、精神药物、胰岛素敏感剂、兴奋剂或饱腹感剂，以及使用方法，例如治疗或预防体重增加或肥胖，促进减肥，抑制食欲，调节饱腹感等。
• Compositions and methods for managing or improving bone disorders, joint disorders, cartilage disorders, or a combination thereof
  申请人：Unigen, Inc.

  公开号：US10583161B2

  公开（公告）日：2020-03-10

  Compositions and methods for bone health, cartilage health or both, are disclosed that include preparing and utilizing a mixture of at least one Morus extract enriched for one or more prenylated flavonoids, at least one Scutellaria extract enriched for one or more free-B-ring flavonoids, and at least one Acacia extract enriched for one or more flavans.

  已公开的用于骨骼健康、软骨健康或两者的组合物和方法包括制备和使用至少一种富含一种或多种前炔基黄酮的桑树提取物、至少一种富含一种或多种游离 B 环黄酮的黄芩提取物和至少一种富含一种或多种黄烷的金合欢提取物的混合物。
• Compositions and methods for joint health
  申请人：Unigen, Inc.

  公开号：US11123393B2

  公开（公告）日：2021-09-21

  The present disclosure provides mixtures of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both capable of modulating joint inflammation, joint pain, joint stiffness, cartilage degradation, or improving mobility, range of motion, flexibility, joint physical function, or any combination thereof. Such a mixture of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both can optionally be used in combination with other joint management agents, such as non-steroidal anti-inflammatory agents/analgesics, COX/LOX inhibiting agents, glucosamine compounds, neuropathic pain relief agents, or the like.

  本公开提供了前炔类黄酮、二苯乙烯类化合物或二者与黄烷或姜黄素或二者的混合物，能够调节关节炎症、关节疼痛、关节僵硬、软骨退化，或改善活动能力、活动范围、柔韧性、关节物理功能或其任意组合。这种前炔类黄酮、二苯乙烯类化合物或二者与黄烷或姜黄素或二者的混合物可以选择性地与其他关节调理剂结合使用，如非甾体抗炎剂/镇痛剂、COX/LOX 抑制剂、氨基葡萄糖化合物、神经性疼痛缓解剂等。
• Stable, homogeneous natural product extracts containing polar and apolar fractions
  申请人：Collaborative Technologies, Inc.

  公开号：US20030026856A1

  公开（公告）日：2003-02-06

  Disclosed are stable, homogeneous dispersions, comprising (a) from about 20 to 90% by weight of a first composition comprising (i) about 60-95% by weight of a first polar solvent, (ii) about 0-40% by weight of one or more second polar solvents, and (iii) water soluble components of a first natural product; and (b) from about 10 to 60% by weight of a second composition comprising: (i) one or more apolar solvents, and (ii) oil soluble organic components of a second natural product; and (c) from about 0.01 to 8% by weight of a non-surface active lipid phosphate or a surface active agent. Also disclosed are methods of forming the stable, homogeneous dispersions of the invention, comprising forming a first composition comprising water soluble components of a first natural product; forming a second composition comprising oil soluble organic components of a second natural product; mixing the compositions and subjecting the mixture to high pressure high shear processing to form a stable, homogeneous dispersion.

  本发明公开了稳定、均匀的分散体，包括(a)约 20-90%（重量）的第一种组合物，其中包括(i)约 60-95%（重量）的第一极性溶剂，(ii)约 0-40%（重量）的一种或多种第二极性溶剂，以及(iii)第一种天然产物的水溶性成分；以及(b)约 10-60%（重量）的第二种组合物，其中包括：(i)一种或多种非极性溶剂，以及(ii)第二种天然产物的油溶性有机成分；以及(c)约 0.01%至 8%（按重量计）的非表面活性脂质磷酸酯或表面活性剂。还公开了形成本发明稳定、均匀分散体的方法，包括形成第一种组合物，该组合物包含第一种天然产物的水溶性成分；形成第二种组合物，该组合物包含第二种天然产物的油溶性有机成分；混合这些组合物，并对混合物进行高压高剪切处理，以形成稳定、均匀的分散体。
• COMPOSITIONS AND METHODS FOR JOINT HEALTH
  申请人：Unigen, Inc.

  公开号：EP3010928A1

  公开（公告）日：2016-04-27