申请人：FMC Corporation
公开号：US04952580A1
公开（公告）日：1990-08-28
Polyhaloalkene compounds of the formula: ##STR1## wherein X is sulfur, oxygen, or nitrogen, Y.sup.1 and Y.sup.2 are fluorine, Z is hydrogen or the same as Y.sup.1 and Y.sup.2, and n is 1-4; provided that: (A) when X is sulfur, Z is fluorine and R is thienyl or substituted thienyl, thianaphthyl or substituted thianaphthyl, thiazolinyl or substituted thiazolinyl, oxadiazolyl or substituted oxadiazolyl, 3,4,4-trifluoro-3-butenyloxycarbonylmethyl, thiadiazolyl substituted by halogen or R.sup.2 S, wherein R.sup.2 is 3,4,4-trifluoro-3-butenyl or R.sup.2 is phenylmethyl or phenylthiomethyl each optionally substituted by halogen or nitro; or R is thiadiazolyl substituted by R.sup.3, wherein R.sup.3 is substituted aryl, arylalkyl, aryloxyalkyl, alkylthio, haloalkylthio, haloarylthio, cyanoalkylthio, arylalkylthio, aryloxyalkylthio, arylthioalkylthio, heterocycloalkylthio, alkenylthio, haloalkenylthio, halocycloalkylalkenylthio, wherein said aryl or heterocyclic groups of R.sup.3 may be mono-, di-, tri-, tetra-, or penta-substituted; or R.sup.3 is an amino group mono- or di- substituted with members independently selected from alkyl, alkylcarbonyl, haloalkylcarbonyl, aryl, arylaminocarbonyl, arylalkylcarbonyl, arylalkoxycarbonyl, and 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarbonyl; (B) when X is oxygen, Z is fluorine and R is C(O)R.sup.1, wherein R.sup.1 is perfluoralkyl, phenyl or substituted phenyl, thienyl or substituted thienyl, furanyl or substituted furanyl, pyrollyl or substituted pyrollyl, or dihydrothiazolylthiomethyl; and (C) when X is nitrogen, R taken with the nitrogen is an isothiocyanate, succinimide, or saccharine group. The compounds exhibit activity against plant nematodes and helminths that are indicators of animal anthelmintic activity and therefore are useful in agriculture and veterinary practice.
化合物的化学式为：##STR1## 其中X为硫、氧或氮，Y.sup.1和Y.sup.2为氟，Z为氢或与Y.sup.1和Y.sup.2相同，n为1-4；但要注意：（A）当X为硫时，Z为氟，R为噻吩基或取代噻吩基、噻并芘基或取代噻并芘基、噻唑啉基或取代噻唑啉基、噁二唑啉基或取代噁二唑啉基、3,4,4-三氟-3-丁烯氧羰基甲基、卤素或R.sup.2S取代的噻唑啉基，其中R.sup.2为3,4,4-三氟-3-丁烯基或苯甲基或苯硫甲基，每个基都可以选择性地取代卤素或硝基；或R为取代基为R.sup.3的噻唑啉基，其中R.sup.3为取代芳基、芳基烷基、芳氧基烷基、烷硫基、卤代烷硫基、卤代芳基硫基、氰基烷硫基、芳基烷硫基、芳氧基烷硫基、芳硫基烷硫基、杂环烷基硫基、烯基硫基、卤代烯基硫基、卤代环烷基烯基硫基，其中R.sup.3的芳基或杂环基可以是单取代、双取代、三取代、四取代或五取代的；或R.sup.3为氨基，单取代或双取代，所取代的基可以独立地选择为烷基、烷基羰基、卤代烷基羰基、芳基、芳基氨基羰基、芳基烷基羰基、芳基烷氧羰基或3-(2,2-二氯乙烯基)-2,2-二甲基环丙烷羰基；（B）当X为氧时，Z为氟，R为C(O)R.sup.1，其中R.sup.1为全氟烷基、苯基或取代苯基、噻吩基或取代噻吩基、呋喃基或取代呋喃基、吡咯基或取代吡咯基、或二氢噻唑啉基硫甲基；（C）当X为氮时，R与氮结合成异硫氰酸酯、琥珀酰亚胺或糖精基团。这些化合物对植物线虫和寄生虫具有活性，这些寄生虫是动物驱虫活性的指标，因此在农业和兽医实践中有用。
