2,6-二异丙基间甲酚 | 28434-93-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 2,6-二异丙基间甲酚
• 中文别名: b-D-吡喃半乳糖苷,甲基3,6-脱水-
• 英文名称: 3-methyl-2,6-diisopropylphenol
• 英文别名: 2,6-Diisopropyl-3-methyl-phenol；2,6-diisopropyl-m-cresol；2,6-diisopropyl-3-methylphenol；3-methyl-2,6-di(propan-2-yl)phenol
• CAS: 28434-93-7
• 化学式: C₁₃H₂₀O
• 分子量: 192.301
• InChiKey: KEGGEHPMMDYTGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2907199090

反应信息

• 作为反应物：
  描述：

  2,6-二异丙基间甲酚 在 二硫化碳 、 三氯化铝 、 氯化亚砜 作用下， 生成 tris-(4-hydroxy-3,5-diisopropyl-2-methyl-phenyl)-sulfonium ; chloride
  参考文献：
  名称：

  Tri (3, 5-di lower alkyl-4-hydroxy phenyl)-sulfonium chlorides and method of preparing same

  摘要：

  公开号：

  US02833827A1
• 作为产物：
  描述：

  2-Hydroxyisopropyl-3-methyl-6-isopropylphenol 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 、 溶剂黄146 为溶剂， 以0.29 g的产率得到2,6-二异丙基间甲酚
  参考文献：
  名称：

  Ramanamma, C. V.; Dinge, A. S.; Paknikar, S. K., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1989, vol. 28, # 1-11, p. 517 - 519

  摘要：

  DOI：

文献信息

• Chloroindate(iii) ionic liquids as catalysts for alkylation of phenols and catechol with alkenes
  作者：H. Q. Nimal Gunaratne、Tobias J. Lotz、Kenneth R. Seddon

  DOI：10.1039/c0nj00301h

  日期：——

  Chloroindate(III) ionic liquids are shown to be versatile catalysts for the alkylation of phenols with alkenes, giving high conversions to alkylated phenols with high selectivities.

  氯铜酸盐(III)离子液体被证明是苯酚与烯烃烷基化的多用途催化剂，能高转化率地生成高选择性的烷基化苯酚。
• PRODUCTION METHOD FOR 4-HYDROXY-2-METHYLBENZOIC ACID
  申请人：HONSHU CHEMICAL INDUSTRY CO., LTD.

  公开号：US20220127216A1

  公开（公告）日：2022-04-28

  An object is to provide a novel production method for 4-hydroxy-2-methylbenzoic acid that is suitable for industrial use. As a solution, a production method for 4-hydroxy-2-methylbenzoic acid that includes performing a step (I) of reacting a compound represented by general formula (1) with carbon dioxide to obtain a compound represented by general formula (2), and then a step (II) of dealkylating the compound represented by general formula (2), is provided.

  本发明旨在提供一种适用于工业生产的4-羟基-2-甲基苯甲酸新型生产方法。解决方案为提供一种4-羟基-2-甲基苯甲酸的生产方法，包括进行步骤（I），将通式（1）表示的化合物与二氧化碳反应以获得通式（2）表示的化合物，然后进行步骤（II），对通式（2）表示的化合物进行脱烷基化。
• NOVEL AGENTS FOR THE TREATMENT OF DISORDERS CONNECTED TO IMPAIRED NEUROTRANSMISSION
  申请人：Fowler Ann

  公开号：US20100074976A1

  公开（公告）日：2010-03-25

  The present invention relates to the use of oregano extracts and their volatile components for the treatment of disorders connected to impaired neurotransmission in animals including humans as well as to dietary supplements, food and feed or pharmaceutical compositions containing such extracts or their volatile components

  本发明涉及使用牛至提取物及其挥发性成分治疗与动物和人类神经传递障碍相关的疾病，以及包含这些提取物或其挥发性成分的膳食补充剂、食品和饲料或药物组合物。
• OREGANO EXTRACT AND ITS COMPONENTS FOR ENHANCING VIGILANCE
  申请人：Fowler Ann

  公开号：US20110070326A1

  公开（公告）日：2011-03-24

  Oregano extract can act as a stimulant, yet it does not interfere with sleep patterns or induce nervousness the way many stimulants such as caffeine can. It also has the benefits of promoting improved vigilance, improving attention and ability to focus on a task, and improving general alertness.

  牛至提取物可以作为一种兴奋剂，但它不会像咖啡因等许多兴奋剂一样干扰睡眠模式或引起紧张。它还具有促进警觉性的好处，提高注意力和专注于任务的能力，并提高一般警觉性。
• Synthesis of hindered phenols
  申请人：ETHYL CORPORATION

  公开号：EP0116712A1

  公开（公告）日：1984-08-29

  A process for the production of 2,6-di-tert-butyl-a-methoxy-p-cresol and high molecular weight hindered phenols produced therefrom. A process is disclosed for the production of the methyl ether of 2,6-di-tert-butyl-p-cresol in such a manner that allows subsequent production of 1,3,5,- trimethyl-2,4,6-tris (3,5,- di-tert-butyl-4-hydroxybenzyl) benzene in the same pot. The process permits substitution of the methanol solvent/reactant with a hydrocarbon or halogenated hydrocarbon solvent to produce the high molecular weight hindered phenol. This aspect of the invention reduces production cost by eliminating expensive centrifugation associated with prior art processes. The process also conserves catalyst by recycling it in the excess methanol. The catalyst is a Mannich base such as 2,6-di-tert-butyl-a-dimethylamino-p-cresol formed from the reactants 2,6-di-tert-butylphenol and formaldehyde with dimethylamine. The invention is an important improvement over prior art processes in that the production of bisphenol coproducts, notably 4,4'-methylenebis(2,6-di-tert-butylphenol) is low.

  一种生产 2,6-二叔丁基-a-甲氧基对甲酚和由此生产的高分子量受阻酚的工艺。本发明公开了一种生产 2,6-二叔丁基对甲酚甲醚的工艺，该工艺允许在同一锅中随后生产 1,3,5,-三甲基-2,4,6-三（3,5,-二叔丁基-4-羟基苄基）苯。该工艺允许用碳氢化合物或卤代碳氢化合物溶剂替代甲醇溶剂/反应剂，以生产高分子量受阻苯酚。本发明省去了现有技术工艺中昂贵的离心分离，从而降低了生产成本。该工艺还通过在过量甲醇中回收催化剂来节省催化剂。催化剂是一种曼尼希碱，如 2,6-二叔丁基-a-二甲氨基对甲酚，由 2,6-二叔丁基苯酚和甲醛与二甲胺反应生成。与现有技术相比，本发明的重要改进在于双酚副产物，特别是 4,4'-亚甲基双（2,6-二叔丁基苯酚）的产量较低。